Effects of Rosuvastatin vs. Simvastatin/ezetimibe on Arterial Wall Stiffness in Patients with Coronary Artery Disease

Liu, Ban; Che, Wenliang; Yan, Hongwei; Zhu, Weidong; Wang, Hongbao

doi:10.2169/internalmedicine.52.0731

Cited by 10 publications

(5 citation statements)

References 29 publications

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“…Direct Treatment of PWV A number of short-term randomised controlled trials investigating the blockade/ inhibition of renin [71], angiotensin converting enzyme/ angiotensin AT1 receptor blockers [72][73][74][75][76][77][78][79][80], endothelin [81], aldosterone [82,83], phosphodiesterase V [84,85], HMGcoA reductase [86][87][88][89][90][91][92] and xanthine oxidase [93] have been shown to reduce aortic PWV. An important randomised trial in patients with early renal impairment showed both PWV and left ventricular mass reduction over 1 year on just 25 mg spironolactone versus placebo, which the authors claimed was independent of BP [94].…”

Section: Origins Of Arterial Stiffness and Nurture Versus Nature?mentioning

confidence: 99%

Future Treatment of Hypertension: Shifting the Focus from Blood Pressure Lowering to Arterial Stiffness Modulation?

Fok

Cruickshank

2015

Curr Hypertens Rep

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Isolated systolic hypertension is the commonest form of hypertension from middle age onwards. Achieving target systolic blood pressure (BP) control remains difficult in everyday clinical practice and even under clinical trial conditions. Most antihypertensive medicines were designed to lower peripheral vascular resistance, which was considered the haemodynamic determinant of hypertension; most are effective in reducing steady but not pulsatile components of BP. Arterial stiffness, defined via aortic length-specific pulse wave velocity (PWV), is thought to be an important determinant of pulse pressure widening through its effects on the timing and amplitude of pressure wave reflection, and/or the aorta's Windkessel function, or its excess 'reservoir' pressure. Whereas pulse pressure is neither an independent nor consistent cardiovascular risk factor, particularly below the age of about 60 years, PWV has become the most powerful predictor of cardiovascular outcomes including mortality, independent of systolic, pulse, mean or other BP components. PWV is therefore a more direct target for treatment. This review addresses the potential therapeutic options for targeting arterial stiffness and the role of pulse pressure.

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Section: Origins Of Arterial Stiffness and Nurture Versus Nature?mentioning

confidence: 99%

Future Treatment of Hypertension: Shifting the Focus from Blood Pressure Lowering to Arterial Stiffness Modulation?

Fok

Cruickshank

2015

Curr Hypertens Rep

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“…For example, in one controlled trial, 36 participants with coronary artery disease were randomized to orally ingest either rosuvastatin (10 mg daily) or simvastatin/ezetimibe (10/10 mg/day) for 8 weeks. In this trial, the value of the baPWV did not change in the simvastatin/ezetimibe group, while it improved significantly in the rosuvastatin-treated group when compared with baseline values (from 1772 ± 430 cm/s to 1603 ± 398 cm/s) and baPWV values for the simvastatin/ezetimibe group [97]. In another clinical trial conducted by Ilyukhin et al, 38 ischemic heart disease patients were administered either 10 mg/day atorvastatin or 20 mg/day simvastatin, for 6 months.…”

Section: Comparison Of Different Statinsmentioning

confidence: 56%

Beneficial Effect of Statin Therapy on Arterial Stiffness

Alidadi

Montecucco

Jamialahmadi

et al. 2021

BioMed Research International

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Arterial stiffness describes the increased rigidity of the arterial wall that occurs as a consequence of biological aging and several diseases. Numerous studies have demonstrated that parameters to assess arterial stiffness, especially pulse-wave velocity, are predictive of those individuals that will suffer cardiovascular morbidity and mortality. Statin therapy may be a pharmacological strategy to improve arterial elasticity. It has been shown that the positive benefits of statin therapy on cardiovascular disease is attributable not only to their lipid-lowering capacity but also to various pleiotropic effects, such as their anti-inflammatory, antiproliferative, antioxidant, and antithrombotic properties. Additionally, statins reduce endothelial dysfunction, improve vascular and myocardial remodeling, and stabilize atherosclerotic plaque. The aim of the present review was to summarize the evidence from human studies showing the effects of statins on arterial stiffness.

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“…On the contrary, 20-week treatment with statins (rosuvastatin or atorvastatin) combined with regular exercise significantly improved exercise capacity and brachial artery PWV, but had no effect on blood pressure [ 76 ]. In patients with coronary artery disease compared with simvastatin/ezetimibe, rosuvastatin was found to more effectively improve arterial wall stiffness [ 77 ]. Although the beneficial effect of statin on stiffness parameters in various patient populations are well established, to date, their effects on stiffness parameters in FH patients has not been investigated.…”

Section: Effect Of Traditional Oral Lipid-lowering Treatment On Arter...mentioning

confidence: 99%

The Importance of Arterial Stiffness Assessment in Patients with Familial Hypercholesterolemia

Kovács

Cseprekál

Lengyel

et al. 2022

JCM

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Cardiovascular diseases are still the leading cause of mortality due to increased atherosclerosis worldwide. In the background of accelerated atherosclerosis, the most important risk factors include hypertension, age, male gender, hereditary predisposition, diabetes, obesity, smoking and lipid metabolism disorder. Arterial stiffness is a firmly established, independent predictor of cardiovascular risk. Patients with familial hypercholesterolemia are at very high cardiovascular risk. Non-invasive measurement of arterial stiffness is suitable for screening vascular dysfunction at subclinical stage in this severe inherited disorder. Some former studies found stiffer arteries in patients with familial hypercholesterolemia compared to healthy controls, while statin treatment has a beneficial effect on it. If conventional drug therapy fails in patients with severe familial hypercholesterolemia, PCSK9 inhibitor therapy should be administered; if these agents are not available, performing selective LDL apheresis could be considered. The impact of recent therapeutic approaches on vascular stiffness is not widely studied yet, even though the degree of accelerated athero and arteriosclerosis correlates with cardiovascular risk. The authors provide an overview of the diagnosis of familial hypercholesterolemia and the findings of studies on arterial dysfunction in patients with familial hypercholesterolemia, in addition to presenting the latest therapeutic options and their effects on arterial elasticity parameters.

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Effects of Rosuvastatin vs. Simvastatin/ezetimibe on Arterial Wall Stiffness in Patients with Coronary Artery Disease

Cited by 10 publications

References 29 publications

Future Treatment of Hypertension: Shifting the Focus from Blood Pressure Lowering to Arterial Stiffness Modulation?

Future Treatment of Hypertension: Shifting the Focus from Blood Pressure Lowering to Arterial Stiffness Modulation?

Beneficial Effect of Statin Therapy on Arterial Stiffness

The Importance of Arterial Stiffness Assessment in Patients with Familial Hypercholesterolemia

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