Effects of Rosa multiflora and Rosa multiflora Complex on Lipid Content in Rats Fed a High-Fat·High-Cholesterol Diet

Choi, Jeong-Hwa; Baek, Jiyun; Choi, Hye‐Jin

doi:10.3746/jkfn.2015.44.6.791

Cited by 3 publications

(3 citation statements)

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“…Glycoside rosamultin is abundant in the root of R. multiflora and shows lipid-lowering effects [ 27 ]. The YC-1102 solution was confirmed to contain rosamultin through an HPLC analysis and standardization [ Supplementary Figure S1 ] [ 16 ]. According to a recent study, rosamultin significantly reduces the mRNA levels of key genes related to adipogenesis and fat synthesis, such as Cebpα , Pparγ , Srebp1c , Fas , Acc , and Ap2 , effectively inhibiting the accumulation of triglycerides in adipocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, previous studies have reported that the roots of R. multiflora have strong anti-inflammatory effects in mouse models of atopic dermatitis [ 15 ]. Interestingly, R. multiflora root showed beneficial effects in reducing cholesterol due to improved bile acid and lipid metabolism in high-fat diet-fed mice [ 16 ]. Previously, our group collected YC-1102, an extract of R. multiflora roots, and found that it effectively reduced high-fat-induced adipogenesis, indicating that YC-1102 has anti-obesity effects and the potential to reduce hepatic fat accumulation [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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The Root Extract of Rosa multiflora Ameliorates Nonalcoholic Steatohepatitis Development via Blockade of De Novo Lipogenesis and Inflammation

Kim,

Lee,

Lee

et al. 2024

CIMB

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Nonalcoholic steatohepatitis (NASH) is characterized by severe inflammation and fibrosis due to an excessive accumulation of triglycerides (TGs) in the liver with a dysregulated de novo lipogenesis (DNL) pathway. In this study, we aimed to evaluate the effectiveness of YC-1102, an extract obtained from the roots of Rosa multiflora, as a nutritional supplement in a diet-induced NASH mouse model. C57BL/6 wild-type mice were fed a fructose, palmitate, and cholesterol (FPC)-containing diet for 16 weeks to induce experimental NASH. A daily oral gavage of YC-1102 and obetichoic acid (OCA) was conducted for 9 weeks. After sacrifice, disease parameters related to hepatic lipids, inflammation, and fibrosis were evaluated. The treatment with YC-1102 significantly decreased the liver/body weight ratio, epididymal fat weight, and plasma ALT and AST levels, which are indicators of NASH injuries. YC-1102 attenuated hepatic lipid accumulation by inhibiting the transcription of DNL genes in the livers exhibiting NASH. Additionally, we found that YC-1102 blocked the development of hepatic inflammation and fibrosis by directly disturbing macrophage activation, resulting in an amelioration of hepatic fibrosis. Our findings suggest that YC-1102 could ameliorate NASH progression by inhibiting uncontrolled DNL and inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Root Extract of Rosa multiflora Ameliorates Nonalcoholic Steatohepatitis Development via Blockade of De Novo Lipogenesis and Inflammation

Kim,

Lee,

Lee

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

“…It was found that rosamultin reduced triglyceride levels in 3T3-L1 cells [20] and inhibited hepatic lipid peroxidation that was induced by promobenzene in rats [21]. Previous studies have shown that R. multiflora significantly lowers blood lipid levels in laboratory animals and exhibits anti-inflammatory and antioxidant properties [22,23]. There is, however, a lack of research on the anti-obesity properties of R. multiflora.…”

Section: Introductionmentioning

confidence: 99%

Effect of YC-1102 on the Improvement of Obesity in High-Fat Diet-Induced Obese Mice

Yu,

Kim,

Baek

et al. 2024

CIMB

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Obesity is one of the major risk factors for metabolic diseases worldwide. This study examined the effects of YC-1102, an extract derived from the roots of Rosa multiflora, on 3T3-L1 preadipocytes and high-fat diet (HFD)-induced obese mice. In vivo experiments involved the oral administration of YC-1102 (100, 150, and 200 mg/kg body weight) daily to mice for eight weeks. YC-1102 was found to downregulate the expressions of PPARγ and C/EBPα during adipogenesis, inhibiting adipocyte differentiation and upregulating the expression of PGC-1α for energy metabolism to enhance mitochondrial biogenesis and fatty acid oxidation. It has been shown that daily administration of YC-1102 to mice receiving a HFD prevented an increase in body weight and the accumulation of body fat. YC-1102 administration also reduced TG, TC, and LDL cholesterol levels, as well as glucose and leptin levels, and increased adiponectin levels, thus effectively inhibiting the metabolism of lipids. YC-1102-treated mice showed significant reductions in the mRNA expression of PPARγ and C/EBPα. The levels of PGC-1α involved in energy metabolism increased significantly in the YC-1102-treated mice when compared to the HFD-treated mice. According to the findings of this study, YC-1102 has a dual mechanism that reduces transcription factors that promote the differentiation of adipocytes and increases transcription factors that promote energy consumption.

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Effects of Oenanthe javanica and Allium tuberosum on Lipid Content in Rats Fed a High-fat·High-cholesterol Diet

Song¹,

Choi²

2016

Journal of Life Science

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This study was conducted to investigate the effects of Oenanthe javanica and Allium tuberosum powder on lipid metabolism in rats fed high fat·high cholesterol diet. Experimental rats were divided into five groups which were composed of normal diet group (N), high fat·high cholesterol diet group (HF), high fat·high cholesterol diet with 5% Oenanthe javanica powder diet group (OP), high fat·high cholesterol diet with 5% Allium tuberosum powder diet group (AP) and high fat·high cholesterol diet with 2.5% Oenanthe javanica and Allium tuberosum powder diet group (OAP). The serum TG content of the HF group was significantly increased compared to the N group, but that of the OAP group was significantly decreased. Serum HDL-cholesterol contents of the OAP group was significantly increased compared to the HF group. The serum total cholesterol, LDL-cholesterol and AI of the HF group were increased compared to the N group and especially the LDL-cholesterol of OP and OAP groups were significantly decreased compared to the HF group. The liver TG and total cholesterol contents of the HF group were significantly increased compared to the N group, while TG contents of the OAP group was significantly decreased compared to the HF group. Fecal total lipid and total cholesterol of OP, AP and OAP groups were significantly increased compared to the HF group. These results suggest that supplementation of Oenanthe javanica and Allium tuberosum may have a pronounced impact on markers of lipid metabolism in serum and liver of rats fed high fat·high cholesterol diets.

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Effects of Rosa multiflora and Rosa multiflora Complex on Lipid Content in Rats Fed a High-Fat·High-Cholesterol Diet

Cited by 3 publications

References 47 publications

The Root Extract of Rosa multiflora Ameliorates Nonalcoholic Steatohepatitis Development via Blockade of De Novo Lipogenesis and Inflammation

The Root Extract of Rosa multiflora Ameliorates Nonalcoholic Steatohepatitis Development via Blockade of De Novo Lipogenesis and Inflammation

Effect of YC-1102 on the Improvement of Obesity in High-Fat Diet-Induced Obese Mice

Effects of Oenanthe javanica and Allium tuberosum on Lipid Content in Rats Fed a High-fat·High-cholesterol Diet

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