Effects of Root and Stem Extracts of <i>Asparagus cochinchinensis</i> on Biochemical Indicators Related to Aging in the Brain and Liver of Mice

Xiong, Dongbin; Yu, Long‐Xi; Yan, Xiao; Guo, Changhong; Xiong, Ying

doi:10.1142/s0192415x11009159

Cited by 45 publications

(37 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, numerous traditional Chinese medicines have been found to possess potent anti-aging activities and have attracted considerable interest as potential candidates for the development of novel anti-aging therapies (20,21). Rhein, one of the major bioactive constituents of the rhizome of rhubarb (Rheum palmatum Linn.…”

Section: Introductionmentioning

confidence: 99%

Effects of rhein lysinate on D-galactose-induced aging mice

Zhen

Lin

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. The aim of the present study was to investigate the anti-aging effects of rhein lysinate (RHL), and to explore its mechanism of action in a D-galactose-induced aging mouse model. Aging was induced by D-galactose (100 mg/kg/day) that was subcutaneously injected to animals for 8 weeks. RHL was simultaneously administered once a day by intragastric gavage. The appetite, mental condition, body weight and organ index of the mice were monitored. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were determined, and the levels of malondialdehyde (MDA) in the liver, kidney and serum were measured by appropriate assay kits. Western blot analysis was used to detect proteins associated with age. The results indicated that RHL may improve the appetite, mental state and organ conditions of the model mice, improve the activities of SOD and GSH-Px, reduce MDA levels and modulate the expression of age-associated proteins (Sirtuin 1, p21 and p16) in D-galactose-induced mice. Therefore, RHL may be effective at suppressing the aging process through a combination of enhancing antioxidant activity, scavenging free radicals and modulating aging-associated gene expression.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of rhein lysinate on D-galactose-induced aging mice

Zhen

Lin

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Asparagus cochinchinesis ( A. cochinchinesis ), a perennial herb belonging to the Liliaceae family, is widely distributed in China, Japan and Korea, and has been used as a traditional medicine in those countries for thousands of years (1). The root of A. cochinchinesis has long been considered a therapeutic drug due to its anti-inflammatory, diuretic, antiseptic, antitussive, antibacterial, nervine, sialogogue, antipyretic and stomachic effects, and is also administered in combination with other herbs as a medicine to treat lung disease, immune system-associated diseases and aging (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…The root of A. cochinchinesis has long been considered a therapeutic drug due to its anti-inflammatory, diuretic, antiseptic, antitussive, antibacterial, nervine, sialogogue, antipyretic and stomachic effects, and is also administered in combination with other herbs as a medicine to treat lung disease, immune system-associated diseases and aging (1,2). …”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, ethanol extract from A. cochinchinesis decreased the degree of ectopic edema, ear thickness, cytokine secretion TNF-α and interleukin (IL)-1β and myeloperoxidase activity in a skin inflammation-induced mouse model treated with 12-O-tetradecanoyl-phorbol-13-acetate, all of which are considered indicators of skin inflammation progression (27). A crude aqueous extract of A. cochinchinensis effectively inhibited TNF-α-induced cytotoxicity (21), increased the spleen index and superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) in mice (1). A recent study reported the inhibitory effects of A. cochinchinensis in allergic asthma-associated airway remodeling.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity

Lee

Koh

Sung

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Asparagus cochinchinesis (A. cochinchinesis) is a medicine traditionally used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although numerous studies of the anti-inflammatory effects of A. cochinchinesis have been conducted, the underlying mechanisms of such effects in macrophages remain to be demonstrated. To investigate the mechanism of suppressive effects on the inflammatory response in macrophages, alterations of the nitric oxide (NO) level, the cell viability, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression levels, inflammatory cytokine expression, the mitogen-activated protein kinase (MAPK) signaling pathway, cell cycle arrest and reactive oxygen species (ROS) levels were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells following treatment with ethyl acetate extract from A. cochinchinesis root (EaEAC). RAW264.7 cells pretreated two different concentrations of EaEAC prior to LPS treatment exhibited no significant toxicity. The concentration of NO was significantly decreased in the EaEAC + LPS treated group compared with the vehicle + LPS treated group. A similar decrease in mRNA transcript level of COX-2, iNOS, pro-inflammatory cytokines [tumor necrosis factor-α and interleukin (IL)-1β] and anti-inflammatory cytokines (IL-6 and IL-10) was detected in the EaEAC + LPS treated group compared with the vehicle + LPS treated group, although the decrease rate varied. Enhancement of the phosphorylation of MAPK family members following LPS treatment was partially rescued in the EaEAC pretreated group, and the cell cycle was arrested at the G2/M phase. Furthermore, the EaEAC pretreated group exhibited a reduced level of ROS generation compared with the vehicle + LPS treated group. Taken together, these results suggest that EaEAC suppresses inflammatory responses through inhibition of NO production, COX-2 expression and ROS production, as well as differential regulation of inflammatory cytokines and cell cycle in RAW264.7 cells. In addition, these results provide strong evidence to suggest that EaEAC may be considered as an important candidate for the treatment of particular inflammatory diseases.

show abstract

“…These include β-sitosterol [19], daucosterol [25], n-ethatriacontanoic acid [31], palmitic acid [14], 9-heptacosylene [41], smilagenin [3], diosgenin [6], sarsasapogenin-3-O-β-D-glucoside feeding grapes imidacloprid [39], 5-methoxy methyl furfural, yame sapogenin, diosgenin-3-O-β-D imidacloprid feeding glucose glycosides [29,39], aspacochioside D [30], iso-agatharesinoside [18] and seven steroidal saponins [15]. Among these, some polysaccharides exhibited therapeutic effects against several diseases such as aging [15,27,43], inflammatory diseases [15], tumor [11,20,36], diabetes [42] and cough [20,22].…”

Section: Introductionmentioning

confidence: 99%

Effects of an Aqueous Extract of Asparagus cochinchinensis on the Regulation of Nerve Growth Factor in Neuronal Cells

Lee¹,

Kim²,

Song³

et al. 2016

Journal of Life Science

View full text Add to dashboard Cite

Asparagus cochinchinensis is a medical plant that has long been used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although several studies have been conducted on the anti-neuroinflammatory effects of A. cochinchinensis, the correlation between these effects and nerve growth factor (NGF) has not yet been examined. In this study, we investigated the effects of an aqueous extract of A. cochinchinensis (AEAC) on the secretion and action mechanism of NGF in neuronal cells. The concentration of the NGF protein in the supernatant collected from cultured cells increased significantly in B35 cells treated with AEAC in comparison with the vehicle-treated group without any specific cytotoxicity. Furthermore, the mRNA expression of NGF showed a very similar pattern to its protein concentration. To examine the bioactivity of NGF secreted from B35 cells, undifferentiated PC12 cells were cultured in an AEAC-conditioned medium and neuritic outgrowth was observed. The dendrite length of PC12 cells in the AEAC-treated group was significantly higher than that in the vehicle-treated group. Moreover, the level of the downstream effectors p-TrkA and p-ERK of the high-affinity NGF receptor was significantly higher in the AEAC-treated group, while the expression of the downstream effectors of the low-affinity NGF receptor was significantly lower in the same group. These results suggest that AEAC may contribute to the regulation of NGF expression and secretion in neuronal cells; it is therefore an excellent candidate for further investigation as a therapeutic drug for neurodegenerative diseases.

show abstract

Effects of Root and Stem Extracts of Asparagus cochinchinensis on Biochemical Indicators Related to Aging in the Brain and Liver of Mice

Cited by 45 publications

References 4 publications

Effects of rhein lysinate on D-galactose-induced aging mice

Effects of rhein lysinate on D-galactose-induced aging mice

Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity

Effects of an Aqueous Extract of Asparagus cochinchinensis on the Regulation of Nerve Growth Factor in Neuronal Cells

Contact Info

Product

Resources

About