Effects of risperidone on information processing and attention in first-episode schizophrenia

Hong, Kyung Sue; Kim, J.G; Koh, H.J; Koo, Malcolm; Lee, D; Kim, E

doi:10.1016/s0920-9964(01)00167-0

Cited by 28 publications

(26 citation statements)

References 30 publications

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“…However, they take much more time to complete the task. These findings corroborate earlier reports of processing speed deficits in SC (Hong et al, 2002;Lussier & Stip, 2001). The processing speed deficit observed in this experiment, under both NLP medications, remained stable until the end of the 12-month follow-up.…”

Section: Discussionsupporting

confidence: 93%

“…These divergent results may be due to differing methodological approaches. In the majority of studies, there is no healthy comparison group (Bilder et al, 2002;Cuesta et al, 2001;Green et al, 2002;Harvey et al, 2003;Kern et al, 1999;Liu et al, 2000;Purdon et al, 2000;Stip & Lussier, 1996); other studies are conducted at a specific point in time (or over a rather short period; Bilder et al, 2002;Harvey et al, 2000Harvey et al, , 2003Hong et al, 2002;Kern et al, 1999;Liu et al, 2000); and some considered the effects of a single treatment only (Stip & Lussier, 1996) or did not use a conventional NLP as a comparison group (Harvey et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…A third explanation of verbal memory enhancement with atypical NLPs is directly linked to optimal control over clinical symptoms, especially negative symptoms (Hong et al, 2002). Atypical drugs have been found to improve psychopathological symptoms over conventional NLP drugs.…”

Section: Introductionmentioning

confidence: 99%

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Long-term effects of risperidoneversushaloperidol on verbal memory, attention, and symptomatology in schizophrenia

Rémillard

Pourcher

Cohen

2007

J Int Neuropsychol Soc

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There is evidence in the literature that cognitive functions in schizophrenia (SC) may be improved by atypical neuroleptics (NLPs) in contrast to typical medication, but there is still controversy regarding this apparent superiority of atypical drugs. In this study, we assessed the differential effects of risperidone and haloperidol on verbal memory, attention, and psychiatric symptoms in SC. The performance of 28 SC participants, randomly assigned to risperidone (2-6 mg0day) or haloperidol (2-40 mg0day), was compared with that of healthy controls. The California Verbal Learning Test (CVLT), the d2 Cancellation Test, and the Positive and Negative Symptoms Scale were administered at baseline and 3, 6, and 12 months. Relative to controls, all SC participants showed markedly impaired verbal memory and processing speed at each assessment period. There was no differential effect between the two NLPs on CVLT and d2 performance. However, risperidone was more effective than haloperidol in reducing psychiatric symptoms. Improvement in symptom severity was not associated with improvement in neurocognitive performance on these specific tests. Neither conventional nor atypical neuroleptic medications improved neurocognitive functioning over a 12-month follow-up, suggesting that psychopathological improvement under risperidone is independent of cognitive function. (JINS, 2008, 14, 110-118.)

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Long-term effects of risperidoneversushaloperidol on verbal memory, attention, and symptomatology in schizophrenia

Rémillard

Pourcher

Cohen

2007

J Int Neuropsychol Soc

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“…Assessments and measurements were repeated at the same time of day on days 7, 28, and 56 for both treatment groups. Severity of psychiatric symptoms was assessed according to the positive and negative symptom scale (PANSS) [16]. Extrapyramidal symptoms (EPS) were rated on the Simpson Angus scale (SAS) and Abnormal involuntary movement scale.…”

Section: Methodsmentioning

confidence: 99%

“…Neither Classen and Laux nor Goldberg et al reported the beneficial effect of clozapine on psychomotor speed, while in the study by Galletly et al clozapine was associated with improvements in accuracy of target detection and reaction time [10,13,14]. Treatment with risperidone showed greater improvement in reaction time than treatment with haloperidol in the study by Kern et al, but in a study by Hong et al risperidone had no effect on psychomotor speed [15,16]. There are practically no data on the effect of olanzapine on simple reaction time.…”

Section: Introductionmentioning

confidence: 97%

Measurement of simple reaction time in antipsychotic treatment of patients with schizophrenia

Plesničar¹,

Zalar

Tomori

et al. 2003

Wien Klin Wochenschr

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Current Awareness

2002

Human Psychopharmacology

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs ‐ General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Effects of risperidone on information processing and attention in first-episode schizophrenia

Cited by 28 publications

References 30 publications

Long-term effects of risperidoneversushaloperidol on verbal memory, attention, and symptomatology in schizophrenia

Long-term effects of risperidoneversushaloperidol on verbal memory, attention, and symptomatology in schizophrenia

Measurement of simple reaction time in antipsychotic treatment of patients with schizophrenia

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