Effects of risperidone and SCH 23390 on isolation-induced aggression in male mice

Rodrı́guez-Arias, Marta; Miñarro, José; Aguilar, M.A.; Pinazo, José; Simón, Vicente M.

doi:10.1016/s0924-977x(97)00051-5

Cited by 126 publications

(83 citation statements)

References 35 publications

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“…The criterion used to define an animal as defeated was the adoption of a specific posture of defeat, characterized by an upright position, limp forepaws, upwardly angled head, and retracted ears (Miczek et al 1982). Defeated mice always exhibit this extreme form of "upright submissive" behavior (Rodríguez-Arias et al 1998).…”

Section: Methodsmentioning

confidence: 99%

Social experiences affect reinstatement of cocaine-induced place preference in mice

et al. 2009

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Section: Methodsmentioning

confidence: 99%

Social experiences affect reinstatement of cocaine-induced place preference in mice

et al. 2009

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“…For instance, risperidone has been shown to attenuate aggression induced by social isolation in mice and apomorphine treatment in rats (Moechars et al 1998;Rodriguez-Arias et al 1998;Skrebuhhova-Malmros et al 2000). Moreover, our laboratory has previously demonstrated that acute and chronic risperidone treatment in a well-documented ethologically valid animal model of heightened offensive aggression reduced aggressive behaviors at doses comparable to those most effective in human adolescents Schwartzer et al 2008).…”

Section: Introductionmentioning

confidence: 95%

Paliperidone suppresses the development of the aggressive phenotype in a developmentally sensitive animal model of escalated aggression

et al. 2008

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Rationale Atypical antipsychotics are commonly prescribed to clinically referred youngsters for treatment of heightened aggressive behavior associated with various psychiatric disorders. Previously, we demonstrated risperidone's antiaggressive effects using a well-validated animal model of offensive aggression. Paliperidone, the main active metabolite of risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist with slightly different pharmacodynamic properties compared to risperidone. Given that much of risperidone's therapeutic efficacy is due to its active metabolite, paliperidone may effectively suppress aggression with fewer adverse side effects. Objectives Investigate whether paliperidone administration would reduce heightened aggressive behavior induced by low-dose cocaine exposure in a developmentally sensitive model of offensive aggression. Materials and methods Male Syrian hamsters (n=12/group) were administered an acute dose of paliperidone (0.05, 0.1, 0.2, and 0.3 mg/kg) and then tested for aggressive behavior using the resident-intruder paradigm. To investigate the effects of chronic paliperidone administration, a separate set of animals (n=12/group) was exposed to repeated paliperidone administration (0.1 mg kg −1 day −1 ) during different developmental periods and varying lengths of time (1-4 weeks). Results Experiment 1 results revealed a dose-dependent decrease in bite and attack behaviors with an effective dose observed at 0.1 mg/kg. In Experiment 2, the maximal reduction in aggressive behavior in response to chronic paliperidone treatment was observed in animals treated during the third week of adolescence, and this reduction occurred without concomitant alterations in non-aggressive behaviors.Conclusions These results support the specific aggressionsuppressing properties of paliperidone and the potential use of this compound in the treatment of maladaptive aggression in clinical settings.

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“…The videotapes were subsequently analyzed using a customdeveloped program (Brain et al 1989) that makes it possible to estimate the time allocated to different broad functional categories of behavior-body care, digging, nonsocial exploration, social investigation, threat and attackeach of which is characterized by a series of different postures and elements. A more detailed description can be found in Rodriguez-Arias et al (1998).…”

Section: Social Interaction Testmentioning

confidence: 99%

Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice

et al. 2011

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Effects of risperidone and SCH 23390 on isolation-induced aggression in male mice

Cited by 126 publications

References 35 publications

Social experiences affect reinstatement of cocaine-induced place preference in mice

Social experiences affect reinstatement of cocaine-induced place preference in mice

Paliperidone suppresses the development of the aggressive phenotype in a developmentally sensitive animal model of escalated aggression

Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice

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