Effects of Rhodomyrtus tomentosa extract on virulence factors of Candida albicans and human neutrophil function

Hmoteh, Jutharat; Musthafa, Khadar Syed; Voravuthikunchai, Supayang Piyawan

doi:10.1016/j.archoralbio.2017.11.007

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…These cells also play an important role in tumor development (Coussens & Werb, 2002). Some studies have shown the activation of macrophage phagocytosis in extracts of the Myrtaceae family and Campomanesia genus (Hmoteh et al, 2018;Park et al, 2015). The inflammatory response depends on the expression of several inflammatory proteins such as cytokines, enzymes, receptors, and adhesion molecules (Barnes, 1994).…”

Section: Resultsmentioning

confidence: 99%

Chemical evaluation and biological activity of bioactive compounds from Campomanesia xanthocarpa Berg

Dalastra

Kael²,

Bonatto³

et al. 2022

RSD

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Campomanesia xanthocarpa Berg. (Myrtaceae), also known as “guabiroba”, is widely distributed in the South and Southern regions of Brazil and has been used by local families as folk medicine to treat several diseases. This study aimed to evaluate the bioactive compounds of guabiroba fruits and leaves, such as flavonoids, carotenoids, chlorophyll, total phenolics, tannins, and coumarins. The biological effect of different parts of C. xanthocarpa (leaf and pulp) was also investigated for the immunomodulatory activity on RAW 264.7 macrophages, and anti-cancer effects on H295R adrenocortical cells under different concentrations and extraction protocols. Extracts from guabiroba leaves and pulp using 70% ethanol and n-hexane as a solvent by magnetic stirring, as well as ethanolic extracts from leaves and pulp obtained by heat reflux extraction were produced. Most of the bioactive compounds were found in the leaves rather than the fruit pulp. The in vitro assays showed that the leaf extraction with hexane affected the viability assay in the adrenocortical cell line H295R, while the pulp extracted with hexane activated the macrophage cell line RAW 264.7. Therefore, C. xanthocarpa leaves and pulp have proven to affect macrophage and adrenocortical cell lines in a dose-dependent manner.

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Section: Resultsmentioning

confidence: 99%

Chemical evaluation and biological activity of bioactive compounds from Campomanesia xanthocarpa Berg

Dalastra

Kael²,

Bonatto³

et al. 2022

RSD

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“…Moreover, MRSA-induced cytotoxicity was decreased at least 50% by R. tomentosa. EER exhibited potential to develop as alternative therapeutic agent against oral candidiasis (Hmoteh et al, 2018). At different dosages, the inhibition of EER against virulence factors of Candida albicans can be interpreted as indicating the decrease in adherence ability to surfaces and biofilm forming ability, and the promotion of phagocytosis and killing effect of neutrophils against the organism.…”

Section: Crude Extractsmentioning

confidence: 99%

Rhodomyrtus tomentosa (Aiton.): A review of phytochemistry, pharmacology and industrial applications research progress

Zhao

Xie

et al. 2020

Food Chemistry

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Rhodomyrtus tomentosa (Aiton) is a flowering plant native to southern and southeastern Asia.Up to date, 106 chemical constituents have been isolated and identified from R. tomentosa. Among these compounds, triterpenoids, flavonoids, phenols and meroterpenoids are the major constituents. Investigations of pharmacological activities of R. tomentosa revealed that this edible medicinal herb exhibits a wide range of therapeutic potential including antibacterial, antitumor, anti-inflammatory and antioxidant activities both in vivo and in vitro. The purpose of this review is to provide an overview of R. tomentosa studies until 2019. This article also intends to review advances in the botanical, phytochemical, pharmacological studies and industrial applications of R. tomentosa, which will provide a useful bibliography for further investigations and applications of R. tomentosa in medicines and foods.

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“…Contemporaneous DS clinical care considers the use as normal treatment choices of local and systemic anti-mycotic drugs miconazole and fluconazole, nystatin, amphotericin B, along with mechanical and chemical agents in the regimen of denture hygiene and avoidance of overnight denture wear. (8) Unfortunately, these chemical solutions can change the physical and mechanical properties. (9) The increase in the resistance to antifungal drugs and potential adverse effects, an alternative way for eliminating Candida spp.…”

Section: Introductionmentioning

confidence: 99%

“…infections is urgently required. (8) Herbal medicine is the use of medicinal herbs for the prevention and treatment of diseases that can harm one's overall health. Recently, there has been an increase in interest in combining traditional herbal treatment with synthetic contemporary medications.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Action of Thyme and Basil Extracts on Different Denture Base Materials

Eltamimi

mohamed

2021

Egyptian Dental Journal

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Effects of Rhodomyrtus tomentosa extract on virulence factors of Candida albicans and human neutrophil function

Cited by 9 publications

References 36 publications

Chemical evaluation and biological activity of bioactive compounds from Campomanesia xanthocarpa Berg

Chemical evaluation and biological activity of bioactive compounds from Campomanesia xanthocarpa Berg

Rhodomyrtus tomentosa (Aiton.): A review of phytochemistry, pharmacology and industrial applications research progress

Antifungal Action of Thyme and Basil Extracts on Different Denture Base Materials

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