Effects of Rh G-CSF on Hemodynamic and Cytokine Response to Bacterial Challange in Conscious Pigs

Haberstroh, Jörg; Lücke, Ivo; Breuer, Heinz‐Peter; Maass, U; Massarrat, Kyros; Früh, Reinhard; Hagedorn, P.; Specht, Bernd-Ulrich von

doi:10.1097/00024382-199409001-00003

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“…Finally, it is possible that G-CSF treatment improves the impaired splanchnic perfusion and this may also help attenuate the rate of bacterial translocation in hemorrhagic shock. The salutary effects of G-CSF on the impaired hemodynamic parameters of experimental animals subjected to bacterial challenge were previously shown [27], and it is reported that recombinant human G-CSF improved the vascular dysfunction in splanchnic ischemia-reperfusion injury by a mechanism(s) that does not depend upon its hematopoietic effects in a nonseptic model of shock [28].…”

Section: Discussionmentioning

confidence: 94%

The Effects of G-CSF Treatment and Starvation on Bacterial Translocation in Hemorrhagic Shock

Agalar¹,

İskit²,

Ağalar³

et al. 1998

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 94%

The Effects of G-CSF Treatment and Starvation on Bacterial Translocation in Hemorrhagic Shock

Agalar¹,

İskit²,

Ağalar³

et al. 1998

Journal of Surgical Research

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The effects of recombinant human granulocyte‐colony stimulating factor on vascular dysfunction and splanchnic ischaemia‐reperfusion injury

Squadrito

Altavilla

Squadrito

et al. 1997

British J Pharmacology

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1 The aim of our study was to investigate the eects of recombinant human granulocyte-colony stimulating factor in a rat model of splanchnic ischaemia-reperfusion injury. 2 Male anaesthetized rats were subjected to clamping of the splanchnic arteries for 45 min. This surgical procedure resulted in an irreversible state of shock (splanchnic artery occlusion shock; SAO shock). Sham operated animals were used as controls. Survival rate, serum tumour necrosis factor-a (TNF-a), neutrophil count, bone marrow myeloid precursor cells, myeloperoxidase activity (MPO; studied as a quantitative means to assess leukocyte accumulation), mean arterial blood pressure and the responsiveness of aortic rings to phenylephrine (PE, 1 nM ± 10 mM) were studied. 3 SAO shocked rats had a decreased survival rate (0% at 4 h of reperfusion, while sham shocked rats survived more than 4 h), increased serum levels of TNF-a (201+10 u ml 71

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Effects of Rh G-CSF on Hemodynamic and Cytokine Response to Bacterial Challange in Conscious Pigs

Cited by 2 publications

References 0 publications

The Effects of G-CSF Treatment and Starvation on Bacterial Translocation in Hemorrhagic Shock

The Effects of G-CSF Treatment and Starvation on Bacterial Translocation in Hemorrhagic Shock

The effects of recombinant human granulocyte‐colony stimulating factor on vascular dysfunction and splanchnic ischaemia‐reperfusion injury

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