Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri

Yu, Xin; Li, Guorong

doi:10.1016/j.exger.2012.08.009

Cited by 68 publications

(42 citation statements)

References 72 publications

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“…Resveratrol rapidly became the molecule of choice to test SIRT1 activation because it was potent, nontoxic, naturally available and inexpensive. Many studies have since shown that resveratrol can extend maximal lifespan in yeast 154–156 , worms 157,158 , flies 159–161 , fish 162–165 and even honeybees 166 (TABLE 1). In mice, resveratrol protects against many of the deleterious effects of a high-calorie diet, delays age-related diseases, increases exercise endurance, and can mimic many of the transcriptional changes caused by calorie restriction 167–171 .…”

Section: Figurementioning

confidence: 99%

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

Bonkowski

Sinclair

2016

Nat Rev Mol Cell Biol

656

534

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The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD+ precursors, have improved organ function, physical endurance, disease resistance and longevity. Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others. These advances have demonstrated that it is possible to rationally design molecules that can alleviate multiple diseases and possibly extend lifespan in humans.

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Section: Figurementioning

confidence: 99%

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

Bonkowski

Sinclair

2016

Nat Rev Mol Cell Biol

656

534

View full text Add to dashboard Cite

show abstract

“…Bolstering this notion are cell culture studies that demonstrated that resveratrol reduced amyloid beta accumulation, ROS, and apoptosis [310] via modulation of nuclear factor-kB and Sirtuin 1 pathways [310–312]. Some preclinical studies suggest that resveratrol extends the lifespan [310, 313, 314]. For example, resveratrol increased cell survival by stimulating Sirtuin 2, a change that increased DNA stability, slowed aging, and extended the lifespan by 70% in yeast models [315].…”

Section: Diet and Healthy Lifestylementioning

confidence: 99%

Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging

Phillips¹

2017

Neural Plasticity

204

121

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The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed against this burgeoning segment of the population is evidence that nonpathological aging is associated with an increased risk for cognitive decline in a variety of domains, changes that can cause mild disability even before the onset of dementia. Given that pharmacological treatments that mitigate dementia are still outstanding, alternative therapeutic options are being investigated increasingly. The results from translational studies have shown that modifiable lifestyle factors—including physical activity, cognitive engagement, and diet—are a key strategy for maintaining brain health during aging. Indeed, a multiplicity of studies has demonstrated relationships between lifestyle factors, brain structure and function, and cognitive function in aging adults. For example, physical activity and diet modulate common neuroplasticity substrates (neurotrophic signaling, neurogenesis, inflammation, stress response, and antioxidant defense) in the brain whereas cognitive engagement enhances brain and cognitive reserve. The aims of this review are to evaluate the relationship between modifiable lifestyle factors, neuroplasticity, and optimal brain health during aging; to identify putative mechanisms that contribute positive brain aging; and to highlight future directions for scientists and clinicians. Undoubtedly, the translation of cutting-edge knowledge derived from the field of cognitive neuroscience will advance our understanding and enhance clinical treatment interventions as we endeavor to promote brain health during aging.

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“…For instance, cranberry protected C. elegans from thermal stress and slowed down the development of AD [16, 50]. Antioxidant resveratrol not only had prolongevity effect but also delayed the development of Alzheimer's disease and Parkinson's disease [51, 52]. Our previous studies reported that RJ/eRJ supplementation not only extended C. elegans lifespan, but also increased their stress resistant capacity.…”

Section: Discussionmentioning

confidence: 99%

Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity inC. elegansmodel of Alzheimer's disease

2016

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Numerous studies have demonstrated that dietary intervention may promote health and help prevent Alzheimer's disease (AD). We recently reported that bee products of royal jelly (RJ) and enzyme-treated royal jelly (eRJ) were potent to promote healthy aging in C. elegans. Here, we examined whether RJ/eRJ consumption may benefit to mitigate the AD symptom in the disease model of C. elegans. Our results showed that RJ/eRJ supplementation significantly delayed the body paralysis in AD worms, suggesting the β-amyloid (Aβ) toxicity attenuation effects of RJ/eRJ. Genetic analyses suggested that RJ/eRJ-mediated alleviation of Aβ toxicity in AD worms required DAF-16, rather than HSF-1 and SKN-1, in an insulin/IGF signaling dependent manner. Moreover, RJ/eRJ modulated the transactivity of DAF-16 and dramatically improved the protein solubility in aged worms. Given protein solubility is a hallmark of healthy proteostasis, our findings demonstrated that RJ/eRJ supplementation improved proteostasis, and this promotion depended on the transactivity of DAF-16. Collectively, the present study not only elucidated the possible anti-AD mechanism of RJ/eRJ, but also provided evidence from a practical point of view to shed light on the extensive correlation of proteostasis and the prevention of neurodegenerative disorders.

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Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri

Cited by 68 publications

References 72 publications

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging

Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity inC. elegansmodel of Alzheimer's disease

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