Effects of resveratrol on lipid metabolism in liver of red tilapia Oreochromis niloticus

This study was conducted to investigate the effect of methomyl (MET) on water quality, growth and antioxidant system of genetically improved farmed tilapia (GIFT, Oreochromis niloticus) in the presence of peppermint as a floating bed. The concentration of NH3-N, NO2−-N, NO3−-N and TP in T3 (with 200 g wet peppermint) was significantly lower ( P < 0.05) than that in T2 (100 g), T1 (50 g) and control, and the nutrient removal rates were 61.90%, 31.59%, 59.86% and 45.92% in 20 days, respectively. Juveniles GIFT (5.1 ± 0.2 g) were exposed to sub-lethal concentrations of 0.2, 2.0, 20 and 200 µg/L of MET for 45 days. After 6 weeks of a feeding trial, percentage weight gain (PWG), specific growth rate (SGR) and feed conversion ratio (FCR) were significantly decreased in 0.2, 2.0, 20 µg/L MET groups respectively and increased in the 200 µg/L MET group. Compared with the control, no significant changes in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) were detected in the 0.2 µg/L group. The significant increase in activities of SOD, CAT and GPx was accompanied by a diminution in reduced glutathione (GSH) levels resulting with tilapia exposed to 2.0, 20, or 200 µg/L for 45 days. The highest rates observed in SOD, CAT, GPx were 157.63%, 164.05% and 167.46% of the control respectively, and the lowest inhibition rate in GSH was 66.42% of the control. Peppermint as a floating bed can alleviate the adverse effects of MET, such as growth retardation and oxidative stress.

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“… 4 – 7 Our recent studies showed RES alleviated lipid metabolism through the PPARα/γ signaling pathway. 8 …”

Section: Discussionmentioning

confidence: 99%

“…Plants have been reported to produce numerous bioactivity effects such as appetite stimulation, growth promotion, antistress and immunostimulation. 3 – 8 …”

Section: Introductionmentioning

confidence: 99%

Effect of methomyl on water quality, growth performance and antioxidant system in liver of GIFT (Oreochromis niloticus) in the presence of peppermint (Mentha haplocalyx Briq.) as a floating bed

et al. 2022

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“…Notably, dietary Eucommia ulmoides leaf extract alleviated liver steatosis and improved liver function in Ictalurus punctatus [12]. Similarly, resveratrol has been found to regulate lipid synthesis and metabolism in the liver of O. niloticus, thus reducing liver damage [13]. Saikosaponin d, by acting on the AMPK/PPARα pathway, has been effective in countering hepatic steatosis induced by an HFD in hybrid grouper (Epinephelus lanceolatusd♂× Epinephelus fuscoguttatus♀) [14].…”

Section: Introductionmentioning

confidence: 99%

“…HFD has been confirmed to induce oxidative stress, disrupt lipid metabolism, reduce immune capacity, and damage liver tissue in tilapia [25][26][27]. Several extracts from traditional Chinese herbs, such as resveratrol [13], total flavanones from Sedum sarmentosum Bunge [28], and total flavones from Glycyrrhiza [29], have been found to regulate lipid metabolism, suppress oxidative stress, alleviate inflammation, and consequently ameliorate HFD-induced liver damage in tilapia. However, there is a notable absence of research on the protective effects and the underlying molecular mechanisms of berberine against fatty liver damage in tilapia.…”

Section: Introductionmentioning

confidence: 99%

Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding

Jia,

Hou,

Zhang

et al. 2024

Antioxidants

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Berberine, a natural alkaloid found abundantly in various medicinal plants, exhibits antioxidative, anti-inflammatory, and lipid metabolism-regulatory properties. Nonetheless, its protective effects and the molecular mechanisms underlying liver injury in fish have not been fully elucidated. The aims of this study were to investigate the antioxidative, anti-inflammatory, and lipid metabolism-regulating effects of berberine against high-fat diet (HFD)-induced liver damage and to clarify the underlying molecular mechanisms. Tilapia were fed diets containing two doses of berberine (50 and 100 mg/kg diet) alongside high fat for 60 days. The results showed that berberine treatments (50 and/or 100 mg/kg) significantly reduced elevated aminotransferases, triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) in the plasma. In the liver, berberine treatments significantly increased the expression of peroxisome proliferator-activated receptor α (pparα) and carnitine palmitoyltransferase 1 (cpt-1) genes, leading to a reduction in lipid accumulation. Meanwhile, berberine treatment suppressed lipid peroxidation formation and enhanced antioxidant capacity. Berberine upregulated the mRNA levels of erythroid 2-related factor 2 (nrf2) and its downstream genes including heme oxygenase 1 (ho-1) and glutathione-S-transferase (gstα). Additionally, berberine attenuated the inflammation by inhibiting the expression of toll-like receptor 2 (tlr2), myeloid differential protein-88 (myd88), relb, and inflammatory cytokines such as interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and il-8. In summary, this study suggested that berberine offers protection against HFD-induced liver damage in tilapia via regulating lipid metabolism, antioxidant status, and immune response. This protective effect may be attributed to the modulation of the Nrf2, TLR2/MyD88/NF-κB, and PPARα signaling pathways.

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“…Modern pharmacological research has proven that HZ exerts anti‐inflammatory, antioxidant, and hypolipidemic effects [7, 8]. Phytochemical investigations indicated that stilbenes, anthraquinones, and flavonoids are the major constituents in HZ, and these ingredients have good lipid‐lowing efficacy [9–11]. Our previous study on a high‐fat diet‐induced hyperlipidemic animal model demonstrated that HZ was effective in ameliorating hyperlipidemia by reducing the levels of TG, TC, and LDL‐C.…”

Section: Introductionmentioning

confidence: 99%

Ultra‐high performance liquid chromatography‐quadrupole/time‐of‐flight mass spectrometry‐based lipidomics reveals key lipid molecules as potential therapeutic targets of Polygonum cuspidatum against hyperlipidemia in a hamster model

Yang

et al. 2023

J of Separation Science

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Polygonum cuspidatum is a homology of traditional medicine and functional food widely distributed around the world. Our previous study on the hyperlipidemic animal model demonstrated that Polygonum cuspidatum was effective in ameliorating hyperlipidemia, which is characterized by lipid disorders. Herein, the regulatory effect of Polygonum cuspidatum on lipid metabolism needs to be known if its hypolipidemic mechanism is desired to clarify. In this study, an ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry-based lipidomic strategy was first applied to investigate the lipidomic patterns of high-fat diet-induced hyperlipidemic hamsters when treated with Polygonum cuspidatum. The results showed that Polygonum cuspidatum improved the lipidomic profile of hyperlipidemia. A total of 65 differential lipids related to the hypolipidemic effect of Polygonum cuspidatum were screened out and identified, and these differential lipids covered various categories, such as phosphatidylcholines, phosphatidylethanolamines, triacylglycerols, sphingomyelins and so on. Orally administrated Polygonum cuspidatum restored these differential lipids back to normal or nearly normal levels. This study adopted lipidomics to reveal the key lipid molecules as potential therapeutic targets of

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Effects of resveratrol on lipid metabolism in liver of red tilapia Oreochromis niloticus

Cited by 6 publications

References 48 publications

Effect of methomyl on water quality, growth performance and antioxidant system in liver of GIFT (Oreochromis niloticus) in the presence of peppermint (Mentha haplocalyx Briq.) as a floating bed

Effect of methomyl on water quality, growth performance and antioxidant system in liver of GIFT (Oreochromis niloticus) in the presence of peppermint (Mentha haplocalyx Briq.) as a floating bed

Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding

Ultra‐high performance liquid chromatography‐quadrupole/time‐of‐flight mass spectrometry‐based lipidomics reveals key lipid molecules as potential therapeutic targets of Polygonum cuspidatum against hyperlipidemia in a hamster model

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