Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

Bass, Timothy M.; Weinkove, David; Houthoofd, Koen; Gems, David; Partridge, Linda

doi:10.1016/j.mad.2007.07.007

Cited by 395 publications

(291 citation statements)

References 38 publications

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“…As the lifespan of different Drosophila species may have different sensitivity to temperature, this may introduce further variation in the data. Indeed, several longevity studies on D. melanogaster at 25°C reported mean lifespans that were longer than we observed here: 42 days (Simon, Shih, Mack & Benzer, 2003); 55–65 days (Hercus, Loeschcke & Rattan, 2003); 59–60 days (Promislow & Haselkorn, 2002); 27–36 days on baker's yeast; and 71 days on brewer's yeast (Bass, Weinkove, Houthoofd, Gems & Partridge, 2007). This suggests that other factors such as diet might also have impacted our measured lifespans.…”

Section: Discussionmentioning

confidence: 42%

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity

Avanesov

Porter

et al. 2018

Aging Cell

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SummaryLifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying life‐history traits and transcriptomes of 14 Drosophila species differing more than sixfold in lifespan, we explored expression divergence and identified genes and processes that correlate with longevity. These longevity signatures suggested that longer‐lived flies upregulate fatty acid metabolism, downregulate neuronal system development and activin signaling, and alter dynamics of RNA splicing. Interestingly, these gene expression patterns resembled those of flies under dietary restriction and several other lifespan‐extending interventions, although on the individual gene level, there was no significant overlap with genes previously reported to have lifespan‐extension effects. We experimentally tested the lifespan regulation potential of several candidate genes and found no consistent effects, suggesting that individual genes generally do not explain the observed longevity patterns. Instead, it appears that lifespan regulation across species is modulated by complex relationships at the system level represented by global gene expression.

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Section: Discussionmentioning

confidence: 42%

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity

Avanesov

Porter

et al. 2018

Aging Cell

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“…However, the prolongevity effect of resveratrol and its underlying mechanisms have been challenged by studies from several labs and remain controversial (Bass et al 2007b;Kaeberlein et al 2005). In this study, we demonstrated the context-dependent effect of resveratrol on lifespan in D. melanogaster.…”

Section: Discussionmentioning

confidence: 67%

“…Middle-aged mice fed a normal ad libitum diet supplemented with resveratrol were healthier but did not live longer than their ageand diet-matched controls (Pearson et al 2008). In D. melanogaster, when resveratrol was added to a normal diet, lifespan extension was observed in one study (Wood et al 2004) but not in another (Bass et al 2007b).…”

Section: Introductionmentioning

confidence: 93%

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Wang

Wheeler

Alberico

et al. 2011

AGE

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Resveratrol, a polyphenolic compound, has been shown to extend lifespan in different organisms. Emerging evidence suggests that the prolongevity effect of resveratrol depends on dietary composition. However, the mechanisms underlying the interaction of resveratrol and dietary nutrients in modulating lifespan remain elusive. Here, we investigated the effect of resveratrol on lifespan of Drosophila melanogaster fed diets differing in the concentrations of sugar, yeast extract, and palmitic acid representing carbohydrate, protein, and fat, respectively. Resveratrol at up to 200 μM in diets did not affect lifespan of wild-type female flies fed a standard, restricted or high sugar-low protein diet, but extended lifespan of females fed a low sugar-high protein diet. Resveratrol at 400 μM extended lifespan of females fed a high-fat diet. Lifespan extension by resveratrol was associated with downregulation of genes in aging-related pathways, including antioxidant peroxiredoxins, insulin-like peptides involved in insulin-like signaling and several downstream genes in Jun-kinase signaling involved in oxidative stress response. Furthermore, resveratrol increased lifespan of superoxide dismutase 1 (sod1) knockdown mutant females fed a standard or high-fat diet. No lifespan extension by resveratrol was observed in wild-type and sod1 knockdown males under the culture conditions in this study. Our results suggest that the gender-specific prolongevity effect of resveratrol is influenced by dietary composition and resveratrol promotes the survival of flies by modulating genetic pathways that can reduce cellular damage. This study reveals the context-dependent effect of resveratrol on lifespan and suggests the importance of dietary nutrients in implementation of effective aging interventions using dietary supplements.

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“…The effect of RSV on lifespan per se has also been widely tested and positive effects documented in both invertebrates and vertebrates (Bhullar & Hubbard, 2015). In C. elegans , a relatively small but reproducible lifespan‐extending effect has been documented by several groups (Wood et al ., 2004; Viswanathan et al ., 2005; Bass et al ., 2007; Agarwal & Baur, 2011; Morselli et al ., 2010; Zarse et al ., 2010). …”

Section: Introductionmentioning

confidence: 99%

Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

et al. 2016

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SummaryReactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules that modulate aging. Recent observations that ROS can promote longevity have to be reconciled with the numerous claims about the benefits of antioxidants on lifespan. Here, three antioxidants [N‐acetylcysteine (NAC), vitamin C, and resveratrol (RSV)] were tested on Caenorhabditis elegans mutants that alter drug uptake, mitochondrial function, and ROS metabolism. We observed that like pro‐oxidants, antioxidants can both lengthen and shorten lifespan, dependent on concentration, genotypes, and conditions. The effects of antioxidants thus reveal an inverted U‐shaped dose–response relationship between ROS levels and lifespan. In addition, we observed that RSV can act additively to both NAC and paraquat, to dramatically increase lifespan. This suggests that the effect of compounds that modulate ROS levels can be additive when their loci of action or mechanisms of action are sufficiently distinct.

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Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

Cited by 395 publications

References 38 publications

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

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