Effects of resveratrol on collagen type II protein in the superficial and middle zone chondrocytes of porcine articular cartilage

Maepa, Makwese; Razwinani, Mapula; Motaung, Keolebogile Shirley

doi:10.1016/j.jep.2015.11.047

Cited by 29 publications

(21 citation statements)

References 46 publications

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“…In 1963, resveratrol was isolated from Polygonum cuspidatum , a traditional Chinese and Japanese medicine [25]. At present, resveratrol has been found in skin and seeds of over 70 plants, including grape, berries, grains, tea, and peanuts [26, 27].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Attenuates Microglial Activation via SIRT1‐SOCS1 Pathway

Zhang

Liu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Microglial activation is involved in a variety of neurological disorders, and overactivated microglial cells can secrete large amount of proinflammatory factors and induce neuron death. Therefore, reducing microglial activation is believed to be useful in treating the disorders. In this study, we used 10 ng/ml lipopolysaccharide plus 10 U/ml interferon γ (LPS/IFNγ) to induce N9 microglial activation and explored resveratrol- (RSV-) induced effects on microglial activation and the underlying mechanism. We found that LPS/IFNγ exposure for 24 h increased inducible nitric oxide synthase (iNOS) and nuclear factor κB (NF-κB) p65 subunit expressions in the cells and enhanced tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) releases from the cells. RSV of 25 μM reduced the iNOS and NF-κB p65 subunit expressions and the proinflammatory factors' releases; the knockdown of silent information regulator factor 2-related enzyme 1 (SIRT1) or suppressor of cytokine signaling 1 (SOCS1) by using the small interfering RNA, however, significantly abolished the RSV-induced effects on iNOS and NF-κB p65 subunit expressions and the proinflammatory factors' releases. These findings showed that microglial SIRT1-SOCS1 pathway may mediate the RSV-induced inhibition of microglial activation in the LPS/IFNγ-treated N9 microglia.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Attenuates Microglial Activation via SIRT1‐SOCS1 Pathway

Zhang

Liu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Resveratrol has been confirmed to inhibit the expression of COX-2 and iNOS, IL-1 β , and TNF α via downregulation of NF- κ B signaling pathway [ 25 ]. It also increases the production of type II collagen at mRNA and protein levels in the superficial and middle zones, but much less in the deep zone in cartilage [ 26 ].…”

Section: Anti-inflammatory Activity Of Tcmmentioning

confidence: 99%

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Liu

Shi

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction, synovial inflammation, and osteophyte formation. No effective treatments are available. The current pharmacological medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, accompanied by possible adverse effects, might ameliorate OA symptoms. But they do not arrest the progression of OA. Traditional Chinese medicine (TCM) provides medical value by modification of disease and symptoms in OA. Valuable work on exploring TCM merits for OA patients has been investigated using modern technologies, although the complicated interacting network among the numerous components indicates the uncertainty of target specification. This review will provide an overview of the action mechanism of TCM in the last 5 years, discussing the TCM activities of anti-inflammation, antiapoptosis, antioxidation, anticatabolism, and proliferation in OA. TCM is a proposed medical option for OA treatment.

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“…High regulation of collagen type II has been observed chondrocytes treated with resveratrol [19]. This makes resveratrol potentially enhancing chondrocyte viability which can be applied in 3D bioprinting of cartilage constructs [20]. Recent publications show that bark and root water extracts of Pterocarpus angolensis plants in the stifle joints from the 3-month-old pig affect the accumulation of collagen type II in porcine articular cartilage in the middle zone.…”

Section: Role Of Medicinal Plants In Chondrocytesmentioning

confidence: 99%

The Potential Effect of Medicinal Plants for Cartilage Regeneration

Alaribe¹,

Razwinani²,

Maepa³

et al. 2019

Cartilage Tissue Engineering and Regeneration Techniques

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Any trauma to a joint such as sports injury can lead to osteoarthritis especially injuries that include torn cartilage, dislocated joints and ligaments. In sports injury specifically, most of the ointments in the market are only applied after physical activity. Repair of the bone and cartilage continues to be a challenge. Autologous and allografts are the gold standard for the treatment of the bone and cartilage. They have an invasive, open surgical procedure that requires the tissue to be harvested from an alternative site within the patient. South Africa is rich in native flora that is currently tapped as medicine by traditional healers. However, little is known about the natural products of our native flora and their potential to serve as a remedy for sports injuries, fracture healing and osteoarthritis. The grand purpose of the project is to explore medicinal plants of South Africa as a potential source for bone and tissue engineering of articular cartilage.

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Effects of resveratrol on collagen type II protein in the superficial and middle zone chondrocytes of porcine articular cartilage

Cited by 29 publications

References 46 publications

Resveratrol Attenuates Microglial Activation via SIRT1‐SOCS1 Pathway

Resveratrol Attenuates Microglial Activation via SIRT1‐SOCS1 Pathway

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

The Potential Effect of Medicinal Plants for Cartilage Regeneration

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