Abstract:Background and Objective
After tooth extraction, the extraction socket undergoes several steps of soft and hard tissue healing. The healing process of the extraction socket is modulated by a range of signaling factors and biochemical agents. It has been reported that resveratrol, a polyphenolic compound, exhibits various biological effects, including anti‐inflammatory, anti‐carcinogenic, antioxidant, and anti‐aging effects, and protects cardiovascular and bone tissues. In this study, we examined the cellular e… Show more
“…The final concentration of resveratrol in the mixture was maintained at 50 μM. 30 To deliver the drug into the extraction socket, we used a gas-tight Hamilton syringe 84877 (Lot No. 541628, Hamilton Co.), after which fibrin sealant (Tisseel; Cat.…”
Section: Drug Delivery For Bone Healingmentioning
confidence: 99%
“…The effect of resveratrol on bone formation following traumatic injury has been evaluated 30 ; however, local delivery of resveratrol after periodontitis induction has not been examined. In this study, we used the local delivery method instead of systemic administration and examined the level of bone formation after tooth extraction followed by periodontitis induction.…”
Section: Resveratrol Enhances Osteoblast Differentiation and Prevents Bone Resorptionmentioning
Objective: To evaluate the effect of resveratrol on periodontal bone regeneration after local delivery and to determine its effect on inflammatory mediators.
Background:Resveratrol is considered an anti-inflammatory polyphenolic stilbene involved in the modulation of inflammation.Materials and Methods: Periodontitis was induced in mouse molars using a 5-day ligature model followed by the left second molar extraction and 50 µM resveratrol treatment for 1 and 2 weeks. We then examined specimens treated for 1 week histologically and with immunostaining. Microfocus-computed tomography (micro-CT) was used to examine the bone volume formation.
“…The final concentration of resveratrol in the mixture was maintained at 50 μM. 30 To deliver the drug into the extraction socket, we used a gas-tight Hamilton syringe 84877 (Lot No. 541628, Hamilton Co.), after which fibrin sealant (Tisseel; Cat.…”
Section: Drug Delivery For Bone Healingmentioning
confidence: 99%
“…The effect of resveratrol on bone formation following traumatic injury has been evaluated 30 ; however, local delivery of resveratrol after periodontitis induction has not been examined. In this study, we used the local delivery method instead of systemic administration and examined the level of bone formation after tooth extraction followed by periodontitis induction.…”
Section: Resveratrol Enhances Osteoblast Differentiation and Prevents Bone Resorptionmentioning
Objective: To evaluate the effect of resveratrol on periodontal bone regeneration after local delivery and to determine its effect on inflammatory mediators.
Background:Resveratrol is considered an anti-inflammatory polyphenolic stilbene involved in the modulation of inflammation.Materials and Methods: Periodontitis was induced in mouse molars using a 5-day ligature model followed by the left second molar extraction and 50 µM resveratrol treatment for 1 and 2 weeks. We then examined specimens treated for 1 week histologically and with immunostaining. Microfocus-computed tomography (micro-CT) was used to examine the bone volume formation.
“…The first objective of our study was to determine the extent to which a rodent model mimics the dimensional changes that occur in the alveolar ridge after tooth extraction (Amler et al 1960;Amler 1969;Johnson 1969). The clinical literature clearly shows that socket healing and ridge resorption are related, but precisely how the bony filling of an extraction socket curtails erosion of the alveolar ridge is not fully understood (Lekovic et al 1997;Lekovic et al 1998;Min et al 2020;reviewed by MacBeth et al 2017). In part, this is due to the fact that most clinical studies simultaneously report alveolar ridge changes and the extent of extraction socket healing (Camargo et al 2000;Pelegrine et al 2010).…”
Section: Tooth Extraction Is Accompanied By Alveolar Ridge Resorption In a Rodent Modelmentioning
Tooth extraction triggers alveolar ridge resorption, and when this resorption is extensive, it can complicate subsequent reconstructive procedures that use dental implants. Clinical data demonstrate that the most significant dimensional changes in the ridge occur soon after tooth extraction. Here, we sought to understand whether a correlation existed between the rate at which an extraction socket heals and the extent of alveolar ridge resorption. Maxillary molars were extracted from young and osteoporotic rodents, and quantitative micro–computed tomographic imaging, histology, and immunohistochemistry were used to simultaneously follow socket repair and alveolar ridge resorption. Extraction sockets rapidly filled with new bone via the proliferation and differentiation of Wnt-responsive osteoprogenitor cells and their progeny. At the same time that new bone was being deposited in the socket, tartrate-resistant acid phosphatase–expressing osteoclasts were resorbing the ridge. Significantly faster socket repair in young animals was associated with significantly more Wnt-responsive osteoprogenitor cells and their progeny as compared with osteoporotic animals. Delivery of WNT3A to the extraction sockets of osteoporotic animals restored the number of Wnt-responsive cells and their progeny back to levels seen in young healthy animals and accelerated socket repair in osteoporotic animals back to rates seen in the young. In cases where the extraction socket was treated with WNT3A, alveolar ridge resorption was significantly reduced. These data demonstrate a causal link between enhancing socket repair via WNT3A and preserving alveolar ridge dimensions following tooth extraction.
“…Over recent years, the active ingredients extracted from medicinal herbs involved in traditional Chinese medicine have been studied for the potential application in osteogenic effects. The compounds include naringin ( Zhao et al, 2022 ), curcumin ( Sarkar and Bose, 2019 ), quercetin ( Ren et al, 2022 ), berberine ( Jia et al, 2019 ), resveratrol ( Min et al, 2020 ), and salvianolic acids ( Ji et al, 2019 ), which boost bone regeneration by promoting bone formation or inhibiting bone resorption.…”
Bone defect repair and fracture healing are critical challenges in clinical treatments. Bioactive natural compounds are potential resources for medications for osteogenic effects. We have identified icariin, the effective ingredient of Epimedium pubescens, to promote osteogenic differentiation of bone mesenchymal stem cells (BMSCs) and repair bone defects. To explore more natural compounds with the potential modality for bone repair, in the present study, we employed an icariin-induced gene expression pattern as an osteogenic model and screened the Connectivity Map database for small molecules with gene expression signatures similar to this model. We verified the effectiveness of this molecule docking approach by introducing hydroxycholesterol, the second highest score of the similarity to icariin, into the osteoinductive experiments in vitro and demonstrated its excellent osteogenic effect on BMSCs compared with a BMP-2-positive control group. Based on the compatible result of hydroxycholesterol, subsequently, ginsenoside Rb1 was chosen as the most drug-like natural compound among the molecule docking results from icariin. Finally, ginsenoside Rb1 was demonstrated to promote the expression of osteoblastic genes and ALP activity in vitro and repair the calvarial defect of rats in vivo. The study aimed to provide diverse choices for clinical application in bone repair and functional regeneration.
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