Effects of Resuscitation Strategy on Extracellular Matrix: Choice Between Destruction and Protection.

Inocencio, Ryan; Chen, H; Alam, Hasan B.; Rhee, Peter; Koustova, Elena

doi:10.1097/00024382-200403001-00461

Cited by 2 publications

(1 citation statement)

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“…In each organ studied, the gene expression profile was dependent on the fluid used for resuscitation [39]. Furthermore, resuscitation influences not only the regulation and functions of cells but also the integrity of the surrounding extracellular matrix [40]. Fluid resuscitation for combat casualties: consensus conferences.…”

Section: Resuscitation Strategiesmentioning

confidence: 99%

Combat Casualty Care Research: From Bench to the Battlefield

2005

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Hemorrhagic shock is the leading cause of death in civilian and combat trauma. Effective hemorrhage control and better resuscitation strategies have the potential of saving lives. The Trauma Readiness and Research Institute for Surgery (TRRI-Surg) was established to address the core mission of the Uniformed Services University, "Learning to Care for Those in Harm's Way," by conducting research to improve the outcome of combat casualties. This article highlights the salient achievements of this research effort in the areas of hemorrhage control, resuscitation, design and testing of devices, and some novel concepts such as the use of profound hypothermia. The impact of these basic science research findings on changes in military medical care and outcome of injured soldiers is also described.

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Section: Resuscitation Strategiesmentioning

confidence: 99%

Combat Casualty Care Research: From Bench to the Battlefield

2005

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An Update on Fluid Resuscitation

Alam

2006

Scand J Surg

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Hemorrhagic shock is the leading cause of death in civilian and military trauma. Effective hemorrhage control and better resuscitation strategies have the potential of saving lives. However, if not performed properly, resuscitation can actually exacerbate cellular injury caused by hemorrhagic shock, and the type of fluid used for resuscitation plays an important role in this injury pattern. It is logical to prevent this cellular injury through wiser resuscitation strategies than attempting immunomodulation after the damage has already occurred. It is important to recognize that unlike numerous other variables, resuscitation is completely under our control. We decide who, when and how should get resuscitated. This paper summarizes data from a number of studies to illustrate the differential effects of commonly used resuscitation fluids on cellular injury, and how these relate to clinical practice. In addition, some novel resuscitation strategies are described that may become clinically available in the near future.

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Effects of Resuscitation Strategy on Extracellular Matrix: Choice Between Destruction and Protection.

Cited by 2 publications

References 0 publications

Combat Casualty Care Research: From Bench to the Battlefield

Combat Casualty Care Research: From Bench to the Battlefield

An Update on Fluid Resuscitation

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