Effects of resistance training and nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production

Jangjo-Borazjani, Soheila; Dastgheib, Maryam; Kiyamarsi, Efat; Jamshidi, Roghayeh; Rahmati-Ahmadabad, Saleh; Helalizadeh, Masoumeh; Iraji, Roya; Cornish, Stephen M.; Mohammadi-Darestani, Shiva; Khojasteh, Zohreh; Azarbayjani, Mohammad Ali

doi:10.1080/13813455.2021.1886117

Cited by 12 publications

(32 citation statements)

References 55 publications

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“…Similarly, a placebo-controlled clinical trial of 40 patients with type 2 diabetes mellitus demonstrated a significant reduction of Homeostatic model assessment for insulin resistance (HOMA-IR) index, and serum levels of insulin, glucose, triglycerides, total cholesterol and low-density lipoprotein (LDL) cholesterol, c-reactive protein (CRP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), by performing resistance training and consuming N. sativa for 8 weeks. 27 In addition, a randomized clinical trial of 117 obese prediabetic subjects determined that the administration of capsules of 450 mg of N. sativa oil 2 times daily or 500 mg of metformin 2 times daily led to statistically similar improvements in body weight, BMI, glycemic, lipid and inflammatory parameters. 28…”

Section: Clinical Studies Of N Sativamentioning

confidence: 99%

Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Maideen

2021

Chonnam Med J

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The use of herbal medicine to manage chronic conditions including diabetes has become a recent global trend. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. The present review is aimed to analyze the antidiabetic activity of N. sativa as many type 2 diabetic patients use it as a complementary therapy along with their modern allopathic medications or as an alternative therapy. The literature was reviewed in databases like Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, Web of science, EMBASE, Directory of open access journals (DOAJ), and reference lists to identify relevant articles supporting the use of N. sativa in diabetes management. Numerous clinical and animal studies have demonstrated the antidiabetic efficacy of black seeds ( N. sativa ) and its major bioactive constituent thymoquinone. Based on these findings patients with diabetes may use N. sativa as an adjuvant therapy, which may help to reduce the dose and incidence of adverse effects of modern antidiabetic medicines.

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Section: Clinical Studies Of N Sativamentioning

confidence: 99%

Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Maideen

2021

Chonnam Med J

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“…Nigella sativa significantly reduced HbA1c (−0.4%; −0.6 to −0.1), body weight (−4.2 kg; −7.2 to −1.2), TC (−17 mg/dl; −31 to −3), LDL-C (−11 mg/dl; −17 to −6), and TG (−12 mg/dl; −21 to −3) (see Figure 24 ). ( Najmi et al, 2012 ; Hosseini et al, 2013 ; Hadi et al, 2015 ; Heshmati et al, 2015 ; Kaatabi et al, 2015 ; Kooshki et al, 2020 ; Jangjo-Borazjani et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

et al. 2022

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Introduction: Many Ayurvedic medicines have the potential for managing type 2 diabetes mellitus (T2DM), with previous systematic reviews demonstrating effectiveness and safety for specific Ayurvedic medicines. However, many of the reviews need updating and none provide a comprehensive summary of all the Ayurvedic medicines evaluated for managing T2DM.Objective: The objective of this systematic review was to evaluate and synthesize evidence on the effectiveness and safety of Ayurvedic medicines for managing T2DM.Inclusion criteria: Published and unpublished RCTs assessing the effectiveness and safety of Ayurvedic medicines for managing T2DM in adults.Methods: The JBI systematic review methodology was followed. A comprehensive search of sources (including 18 electronic databases) from inception to 16 January 2021 was made. No language restrictions were applied. Data synthesis was conducted using narrative synthesis and random effects meta-analyses, where appropriate. Pooled results are reported as mean differences (MD) with 95% confidence intervals (CI).Results: Out of 32,519 records identified from the searches, 219 articles were included in the systematic review representing 199 RCTs (21,191 participants) of 98 Ayurvedic medicines. Overall, in the studies reviewed the methodology was not adequately reported, resulting in poorer methodological quality scoring. Glycated hemoglobin (HbA1c) was reduced using Aegle marmelos (L.) Corrêa (MD -1.6%; 95% CI −3 to −0.3), Boswellia serrata Roxb. (−0.5; −0.7 to −0.4), Gynostemma pentaphyllum (Thunb.) Makino (−1; −1.5 to −0.6), Momordica charantia L. (−0.3; −0.4 to −0.1), Nigella sativa L. (−0.4; −0.6 to −0.1), Plantago ovata Forssk. (−0.9; −1.4 to −0.3), Tinospora cordifolia (Willd.) Hook.f. and Thomson (−0.5; −0.6 to −0.5), Trigonella foenum-graecum L. (−0.6; −0.9 to −0.4), and Urtica dioica L. (−1.3; −2.4 to −0.2) compared to control. Similarly, fasting blood glucose (FBG) was reduced by 4–56 mg/dl for a range of Ayurvedic medicines. Very few studies assessed health-related quality of life (HRQoL). Adverse events were not reported in many studies, and if reported, these were mostly none to mild and predominately related to the gastrointestinal tract.Conclusion: The current evidence suggests the benefit of a range of Ayurvedic medicines in improving glycemic control in T2DM patients. Given the limitations of the available evidence and to strengthen the evidence base, high-quality RCTs should be conducted and reported.

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“…All the included trials had parallel designs and were published between 2012 and 2022. These studies were carried out in Iran ( 19 , 21 , 37 , 41 , 43 , 45 , 46 ), India ( 40 , 44 ), Egypt ( 20 ), and Saudi Arabia ( 42 ). In total, 666 participants (338 interventions and 328 controls) were recruited with the age range between 42.9 ± 3.2 and 56 ± 3.4 years old and the BMI range between 26.79 ± 2.94 and 33.90 ± 2.10 kg/m 2 .…”

Section: Resultsmentioning

confidence: 99%

“…In total, 666 participants (338 interventions and 328 controls) were recruited with the age range between 42.9 ± 3.2 and 56 ± 3.4 years old and the BMI range between 26.79 ± 2.94 and 33.90 ± 2.10 kg/m 2 . Nine studies included both genders, whereas two studies were performed exclusively on females ( 19 , 45 ). All the participants were individuals with T2DM except one study including those with prediabetes ( 20 ).…”

Section: Resultsmentioning

confidence: 99%

“…The dose of N. sativa supplementation ranged from 0.9 to 5 g/day, with the length of follow-up ranging from 2 to 6 months throughout the studies. Of the 11 RCTs, 9 effect sizes administered oil form of the supplement ( 20 , 21 , 37 , 40 , 41 , 43 – 46 ) and the remaining used extracts of N. sativa ( 19 , 42 ) as an investigational product. All the 11 included trials had appropriate controlled designs, and the only difference between the two groups in each study was the N. sativa intervention.…”

Section: Resultsmentioning

confidence: 99%

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Nigella sativa supplementation improves cardiometabolic indicators in population with prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

et al. 2022

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ObjectiveNigella sativa (N. sativa) from the family Ranunculaceae has medicinal properties. Previous studies have reported promising findings showing that N. sativa may benefit cardiometabolic health; however, current evidence on its cardiometabolic effects on those with prediabetes and type 2 diabetes mellitus (T2DM) is still unclear. Hence, we conducted a systematic review and meta-analysis to assess the efficacy of N. sativa on cardiometabolic parameters in population with prediabetes and T2DM.MethodsPubMed/Medline, ISI Web of Science, Scopus, and Cochrane library were systematically searched up to June 20, 2022. Meta-analyses using random-effects models were used.ResultsEleven randomized controlled trials (RCTs) were included in the meta-analysis. N. sativa intervention resulted in significant changes in fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), c-reactive protein (CRP), and malondialdehyde (MDA), without overall changes in glucose levels after oral glucose tolerance test (OGTT), fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride, high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI) when compared with the control group. In subgroup analyses, N. sativa supplementation enhanced serum levels of HDL-C in subjects with baseline HDL-C lower than 40 mg/dL. Furthermore, HOMA-IR and BMI values decreased in the N. sativa-supplemented group compared with the control group, when the length of follow-up was more than 8 weeks and the dose was more than 1 g/day for N. sativa supplementation, respectively.ConclusionOur findings indicate that N. sativa supplementation may effectively improve cardiometabolic profiles in individuals with prediabetes and T2DM.

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Effects of resistance training and nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production

Cited by 12 publications

References 55 publications

Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis

Nigella sativa supplementation improves cardiometabolic indicators in population with prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

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