Effects of resistance plus aerobic training on body composition and metabolic markers in older breast cancer survivors undergoing aromatase inhibitor therapy

Paulo, Thaís Reis Silva de; Winters-Stone, Kerri M.; Viezel, Juliana; Rossi, Fabrí­cio Eduardo; Simões, Regina R.; Tosello, Giuliano; Freitas, Ismael F.

doi:10.1016/j.exger.2018.07.022

Cited by 36 publications

(90 citation statements)

References 42 publications

(40 reference statements)

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“…Together with the metabolic dysfunction that already occurs post menopause, aromatase inhibition therapy may exacerbate these issues by decreasing motivation for engaging in physical activity. Indeed, aromatase inhibition therapy associates with reduced physical activity in humans (Brown et al (2014); (de Paulo et al, 2018). In addition, males are also prescribed aromatase inhibitors, often to treat the decrease in endogenous testosterone that occurs with increasing age, but the cognitive effects of aromatase inhibition in men have not been thoroughly assessed (Dias et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice

Shay

Welly

Givan

et al. 2020

Hormones and Behavior

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Aromatase catalyzes conversion of testosterone to estradiol and is expressed in a variety of tissues, including the brain. Suppression of aromatase adversely affects metabolism and physical activity behavior, but mechanisms remain uncertain. The hypothesis tested herein was that whole body aromatase deletion would cause gene expression changes in the nucleus accumbens (NAc), a brain regulating motivated behaviors such as physical activity, which is suppressed with loss of estradiol. Metabolic and behavioral assessments were performed in male and female wild-type (WT) and aromatase knockout (ArKO) mice. NAc-specific differentially expressed genes (DEGs) were identified with RNAseq, and associations between the measured phenotypic traits were determined. Female ArKO mice had greater percent body fat, reduced spontaneous physical activity (SPA), consumed less energy, and had lower relative resting energy expenditure (REE) than WT females. Such differences were not observed in ArKO males. However, in both sexes, a top DEG was Pts, a gene encoding an enzyme necessary for catecholamine (e.g., dopamine)

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Section: Introductionmentioning

confidence: 99%

Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice

Shay

Welly

Givan

et al. 2020

Hormones and Behavior

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“…The combination of both resistance and aerobic training performed at intensities above 60% of the 1 RM and maximum heart rate improved the quality of life of WSBC who were overweight or obese (Dieli-Conwright et al, 2018). In addition, 9 weeks of resistance exercises combined with aerobic exercises positively affected the quality of life and body composition increased the lean mass and decreased the percentage of fat and BMI of WSBC who were being treated with aromatase inhibitors (IAs) (Thomas et al, 2017;Paulo et al, 2018Paulo et al, , 2019.…”

Section: Specific Outcomesmentioning

confidence: 99%

Different Methods of Physical Training Applied to Women Breast Cancer Survivors: A Systematic Review

et al. 2021

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Objective: The objective of this systematic review was to identify the effects of different training methods in women who have survived breast cancer (WSBC).Data Sources: Studies were identified by searching SportDiscus, Web of Science, PubMed, Scopus, Scielo, and Bireme.Study Selection: The inclusion criteria were articles that addressed only breast cancer in women, were randomized clinical trials, and interventions involving physical training with Consort ≥80.Data Extraction: The PICO and CONSORT strategies were used for the selection of articles and quality assessment of randomized clinical trials, respectively. Two independent reviewers searched for articles among the databases. Disagreements were discussed, and in the case of an impasse, a third reviewer was consulted.Data Synthesis: Evidence that demonstrated the beneficial effects of physical exercise programs carried out by WSBC. Moderate or high-intensity exercise sessions have been shown to benefit women survivors of breast cancer. Among the modalities, the resistance exercise showed effects from 55% of one-repetition maximum (1 RM), exclusively or associated with other training regimes, such as aerobic (from 48% of heart rate), high-intensity interval training (HIIT), or impact. The main benefits include increased muscle strength, promoted by the practice of resistance exercise in combination with other types of exercises or alone; decreased fatigue; improved quality of life; improved psychosocial effects, and increased leisure time.Conclusions: Physical training performed at a moderate or high intensity (aerobic or anaerobic) can reduce fatigue, improve quality of life, improve sleep quality, and increase bone mineral density in women survivors of breast cancer.

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“…These results add significant data about the importance of biobehavioral factors as mediators of fatigue management in BC patients. According to de Paulo et al [ 163 ], 9 months of supervised high-intensity combined training performed three times per week can increase those parameters, such as total and fat mass, HDL and osteocalcin levels, decreasing the side effects of aromatase inhibitors in old BC patients. In 2018 and 2019, Mijwel et al [ 69 , 100 ] proposed two different types of high-intensity interval training (HIIT), as well as a combined and aerobic protocol, to BC patients during and after treatment.…”

Section: Physical Activity and Exercise As Fundamental Approaches Within Er-positive Breast Cancer At Each Disease Prevention Levelmentioning

confidence: 99%

Estrogen-Receptor-Positive Breast Cancer in Postmenopausal Women: The Role of Body Composition and Physical Exercise

Dimauro

Grazioli

Antinozzi

et al. 2021

IJERPH

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Breast cancer (BC) is the most commonly diagnosed cancer among women worldwide and the most common cause of cancer-related death. To date, it is still a challenge to estimate the magnitude of the clinical impact of physical activity (PA) on those parameters producing significative changes in future BC risk and disease progression. However, studies conducted in recent years highlight the role of PA not only as a protective factor for the development of ER+ breast cancer but, more generally, as a useful tool in the management of BC treatment as an adjuvant to traditional therapies. In this review, we focused our attention on data obtained from human studies analyzing, at each level of disease prevention (i.e., primary, secondary, tertiary and quaternary), the positive impact of PA/exercise in ER+ BC, a subtype representing approximately 70% of all BC diagnoses. Moreover, given the importance of estrogen receptors and body composition (i.e., adipose tissue) in this subtype of BC, an overview of their role will also be made throughout this review.

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Effects of resistance plus aerobic training on body composition and metabolic markers in older breast cancer survivors undergoing aromatase inhibitor therapy

Abstract: Our aerobic + resistance exercise program prevented fat gain, but may not have been sufficient to improve metabolic or bone health markers in older breast cancer survivors undergoing aromatase inhibitor therapy.

Cited by 36 publications

References 42 publications

Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice

Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice

Different Methods of Physical Training Applied to Women Breast Cancer Survivors: A Systematic Review

Estrogen-Receptor-Positive Breast Cancer in Postmenopausal Women: The Role of Body Composition and Physical Exercise

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Effects of resistance plus aerobic training on body composition and metabolic markers in older breast cancer survivors undergoing aromatase inhibitor therapy

Abstract: Our aerobic + resistance exercise program prevented fat gain, but may not have been sufficient to improve metabolic or bone health markers in older breast cancer survivors undergoing aromatase inhibitor therapy.

Cited by 36 publications

References 42 publications

Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice

Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice

Different Methods of Physical Training Applied to Women Breast Cancer Survivors: A Systematic Review

Estrogen-Receptor-Positive Breast Cancer in Postmenopausal Women: The Role of Body Composition and Physical Exercise

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Abstract: Our aerobic + resistance exercise program prevented fat gain, but may not have been sufficient to improve metabolic or bone health markers in older breast cancer survivors undergoing aromatase inhibitor therapy.