Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial

Yoon, Dong Hyun; Lee, Jun Young; Song, Wook

doi:10.1007/s12603-018-1090-9

Cited by 143 publications

(155 citation statements)

References 40 publications

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“…Further more, physical activity may affect individual independence as well as essential mental aspects of quality of life [29]. Studies have also shown an association between physical activity/inactivity and cognitive abilities in elderly [30][31][32]. Measurement of the handgrip strength is easy to perform and it is precise enough to identify the slightest changes in the handgrip strength, especially in elderly who exercise regularly.…”

Section: Discussionmentioning

confidence: 99%

The influence of physical Activity on handgrip strength of elderly

Bilajac¹,

Juraga²,

Žuljević³

2019

Arch Gerontol Geriatr Res

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The global population aged 60 years and over will reach nearly 2.1 billion by 2050. During the aging process, the strength of the musculoskeletal system decreases and it is essential to be moderately physically action to prevent negative changes in muscle cells. Because the handgrip strength test is a robust predictor of the overall state of strength and physical frailty, it was used in this study to demonstrate physical functionality and muscle weakness related to physical activity. Examinees who participated in the study were elderly people aged 60 years and older who regularly performed exercises twice a week under the guidance of physiotherapy students. This research aims to present the results of the measurement of the handgrip regarding regular physical activity. Data were analyzed by paired sample t-test and p-value <0.05 was considered signifi cant. Handgrip strength test results (for a total of 47 subjects) show a statistically signifi cant difference in both hands before and after the exercise period (right hand: p= 0.0085, left hand: p= 0.0001), suggesting that regular exercise affects grip strength as a predictor of older people's physical functioning and improvement of their quality of life.

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Section: Discussionmentioning

confidence: 99%

The influence of physical Activity on handgrip strength of elderly

Bilajac¹,

Juraga²,

Žuljević³

2019

Arch Gerontol Geriatr Res

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“…One article was removed due to the absence of standard deviation data and an inability to obtain the original data from the author [40]. Ultimately, seven studies were included in the analysis, all having a pre-test and a post-test [24,[27][28][29][30][31][32]. The detailed flow of the filtering process is shown in ▶Fig.…”

Section: Literature Screeningmentioning

confidence: 99%

“…Some trials suggested that resistance training can improve general cognitive function [27][28][29], executive function [24,27,29] and working memory [30] in MCI patients. A small number of trials have presented opposite views, finding that MCI patients did not perform better in general cognitive function [30,31], executive function [30] or working memory [27,31,32] after intervention. Therefore, there is no consensus on the benefits of resistance training on cognitive function in MCI patients.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis: Resistance Training Improves Cognition in Mild Cognitive Impairment

Zhang

Yang

et al. 2020

Int J Sports Med

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This study investigated the benefits of resistance training on cognition in patients with mild cognitive impairment. We searched the PubMed, Embase and Cochrane Library databases, and seven randomized controlled trials were reviewed. We evaluated the risk of bias using the Cochrane Collaboration’s bias assessment tool. Standard mean differences with 95% confidence intervals were calculated for statistical analysis. This meta-analysis assessed three variables: general cognitive function, executive function and working memory. The results indicate that general cognitive function improved significantly (standardized mean difference: 0.53, P=0.04), and further subgroup analyses on frequency and duration per session showed that the subgroups ‘twice a week’ (P=0.01) and ‘duration per session >60 min’ (P=0.0006) exhibited better performance than the subgroups ‘three time a week’ (P=0.47) and ‘duration per session <60 min’ (P=0.53). Additionally, a moderate effect size was found in executive function (standardized mean difference: 0.50, P=0.0003), and there was non-significant effect in working memory (P=0.14). In summary, resistance training may mitigate mild cognitive impairment by improving cognition. Larger-scale studies are recommended to demonstrate the relationship between resistance training and cognition in mild cognitive impairment.

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“…Results have generally suggested that improvements in neurocognition following aerobic training are strongest in frontal-subcortical functions, including attention and executive functions, although improvements across other domains also have been noted [117,118]. Similar findings have been reported from resistance training interventions, with participants randomized to exercise demonstrating improvements relative to controls [130] and a tendency for the pattern of improvements to favor frontal-subcortical functions [131,132]. As discussed in more detail below, the largest source of variation across studies appears not to be whether they can improve neurocognition, but whether the observed improvements can be attributed to changes in fitness or other downstream mechanisms.…”

Section: Physical Activitymentioning

confidence: 56%

Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition

Smith

2019

BPL

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Alzheimer's disease and related dementias (ADRD) represent an increasingly urgent public health concern, with an increasing number of baby boomers now at risk. Due to a lack of efficacious therapies among symptomatic older adults, an increasing emphasis has been placed on preventive measures that can curb or even prevent ADRD development among middle-aged adults. Lifestyle modification using aerobic exercise and dietary modification represents one of the primary treatment modalities used to mitigate ADRD risk, with an increasing number of trials demonstrating that exercise and dietary change, individually and together, improve neurocognitive performance among middle-aged and older adults. Despite several optimistic findings, examination of treatment changes across lifestyle interventions reveals a variable pattern of improvements, with large individual differences across trials. The present review attempts to synthesize available literature linking lifestyle modification to neurocognitive changes, outline putative mechanisms of treatment improvement, and discuss discrepant trial findings. In addition, previous mechanistic assumptions linking lifestyle to neurocognition are discussed, with a focus on potential solutions to improve our understanding of individual neurocognitive differences in response to lifestyle modification. Specific recommendations include integration of contemporary causal inference approaches for analyzing parallel mechanistic pathways and treatment-exposure interactions. Methodological recommendations include trial multiphase optimization strategy (MOST) design approaches that leverage individual differences for improved treatment outcomes.

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Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial

Cited by 143 publications

References 40 publications

The influence of physical Activity on handgrip strength of elderly

The influence of physical Activity on handgrip strength of elderly

Meta-analysis: Resistance Training Improves Cognition in Mild Cognitive Impairment

Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition

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