Effects of repetitive transcranial magnetic stimulation in combination with a low-carbohydrate diet in overweight or obese patients. A randomized controlled trial.

Alvarado-Reynoso, Beatriz; Ambriz-Tututi, Mónica

doi:10.1016/j.obmed.2019.100095

Cited by 4 publications

(10 citation statements)

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“… 12 Alvarado-Reynoso in 2019 used 10 trains of 100 pulses given at 10 Hz and 90% of motor threshold, with more sessions employed compared to the two studies. 13 While all these produced weight loss, the degree of weight loss and reduction in food cravings were different among the 3 studies.…”

Section: Discussionmentioning

confidence: 91%

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in Inducing Weight Loss among Obese Filipino Patients: A Randomized Controlled Trial

Encarnacion

Dampil

Damian

et al. 2020

JAFES

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Objective. To determine the efficacy of rTMS in decreasing body mass index (BMI) versus sham stimulation among obese Filipino patients. Methodology. This was a single-center, randomized, sham-controlled, single-blind, parallel group trial. Participants were 15-65 years old with BMI ≥30 kg/m2 and weight stable for 6 weeks. Participants were randomized to receive real rTMS or sham stimulation. Each underwent 4 sessions of stimulation over 2 weeks. Anthropometrics, total caloric intake (TCI), and VAS score for appetite were taken at baseline, 2, 4, 6, and 12 weeks. Results. A total of 31 patients were randomized with 15 to the treatment and 14 to sham stimulation completing treatment, with 2 lost to follow-up. A significant decrease in BMI was noted after 4 weeks from the start of rTMS in the treatment group, (0.6±0.6, p-value=0.001), with weight change of -1.3±1.3 kg (p-value=0.009), but was no longer observed at 6 weeks onwards. No severe adverse effects were noted. Conclusion. rTMS to the DLPFC effectively decreased BMI (0.6±0.6) and weight (-1.3±1.3 kg) from baseline to 4 weeks. At 6-12 weeks after rTMS however, there was no longer a significant difference, indicating that 4 sessions of rTMS may not be enough to produce a prolonged effect on weight loss.

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Section: Discussionmentioning

confidence: 91%

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in Inducing Weight Loss among Obese Filipino Patients: A Randomized Controlled Trial

Encarnacion

Dampil

Damian

et al. 2020

JAFES

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“…All studies that used TMS reported changes in BMI except one 30 . The pooled results revealed a significant effect for TMS on BMI in patients with obesity (MD = − 0.74, 95% CI [−1.17, −0.31]; I 2 = 0% p = .00) favouring active TMS over sham interventions (Figure 2B).…”

Section: Resultsmentioning

confidence: 94%

“…The number of stimulation sessions ranged from 1 to 20 sessions and the duration of each session ranged from 20 to 40 min. Only six studies used hypocaloric diet alongside the intervention (Gluck et al two studies) 29,30,38–40 . Duration of intervention ranged from 4 to 28 days however, most of the studies with 4–5 weeks of intervention.…”

Section: Resultsmentioning

confidence: 99%

“…Only six studies used hypocaloric diet alongside the intervention 29,30,38–40 . One study has used TMS 30 and five studies have used tDCS 28,37–39 .…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have found that stimulation of the dorsolateral prefrontal cortex (DLPFC) can reduce body weight, food cravings, and food consumption 20,30–32 . However, no systematic reviews exploring the effect of brain neuromodulation on body weight have been conducted to date.…”

Section: Introductionmentioning

confidence: 99%

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The use of non‐invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta‐analysis

et al. 2023

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SummarySeveral studies demonstrated non‐invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are safe and simple techniques that can reduce body weight, food cravings, and food consumption in patients with obesity. However, a systematic to evaluate the efficacy of active NIBS versus sham stimulation in reducing body weight and food cravings in patients with obesity is not available. We conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs) using PubMed, Embase, MEDLINE, and Cochrane Central Register of Control Trial between January 1990 and February 2022. Mean differences (MDs) for continuous outcome variables with 95% confidence intervals (95% CIs) were used to examine the effects of NIBS on body weight and body mass index (BMI), whereas the hedges's g test was used to measure the effects on food craving. Nineteen RCTs involving 571 participants were included in this study. Active neurostimulation (TMS and tDCS) was significantly more likely than sham stimulation to reduce body weight (TMS: −3.29 kg, 95% CI [−5.32, −1.26]; I2 = 48%; p < .001; tDCS: −0.82 kg, 95% CI [−1.01, −0.62]; I2 = 0.0%; p = .00) and BMI (TMS: −0.74, 95% CI [−1.17, −0.31]; I2 = 0% p = .00; tDCS: MD = −0.55, 95% CI [−2.32, 1.21]; I2 = 0% p = .54) as well as food cravings (TMS: g = −0.91, 95% CI [−1.68, −0.14]; I2 = 88 p = .00; tDCS: g = −0.32, 95% CI [−0.62, −0.02]; p = .04). Compared with sham stimulation, our findings indicate that active NIBS can significantly help to reduce body weight and food cravings. Hence, these novel techniques may be used as primary or adjunct tools in treating patients with obesity.

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Looking for crumbs in the obesity forest: anti-obesity interventions in the Mexican population. History, and systematic review with Meta-Analysis

García-Oropesa

Ruiz-Cejudo

et al. 2021

Preprint

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Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthetize the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without inferior temporal limit. The systematic review included RCT of anti-obesity treatments in the Mexican adult population, including alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions reporting biometric outcomes such as BMI, weight, waist circumference, triglycerides, glucose, among others. Studies with at least three months of treatment were included in the meta-analysis. We found 634 entries, after removal of duplicates and screening the studies based on eligibility criteria, we analyzed 43, and 2 multinational-collaborative studies. Most of the national studies have small sample sizes, and the studied strategies do not have replications in the population. The nutrition/behavioral interventions were difficult to blind, and most studies have medium to high risk of bias. Nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like plain water instead of sweet beverages decrease triglycerides and systolic blood pressure. Participants with obesity and hypertension can have benefic effects with antioxidants, and treatment with insulin increase weight in those with T2D. The study of obesity in Mexico has been on-going for more than four decades, but the interest on RCT just increased until this millennium, but with small sample sizes and lack of replication. The interventions affect different metabolic syndrome components, which should be analyzed in detail with the population living on the U.S.-Mexico border; therefore, bi-national collaboration is desirable to disentangle the cultural effects on this population's treatment response.

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Effects of repetitive transcranial magnetic stimulation in combination with a low-carbohydrate diet in overweight or obese patients. A randomized controlled trial.

Cited by 4 publications

References 45 publications

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in Inducing Weight Loss among Obese Filipino Patients: A Randomized Controlled Trial

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) in Inducing Weight Loss among Obese Filipino Patients: A Randomized Controlled Trial

The use of non‐invasive brain stimulation techniques to reduce body weight and food cravings: A systematic review and meta‐analysis

Looking for crumbs in the obesity forest: anti-obesity interventions in the Mexican population. History, and systematic review with Meta-Analysis

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