Effects of Repeated X-Radiation of the Whole Body on the Development of Tumours in Rats Due to Feeding p-Dimethylaminoazobenzene

Hoch-Ligeti, Cornelia

doi:10.1038/bjc.1949.63

Cited by 5 publications

(6 citation statements)

References 3 publications

(2 reference statements)

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“…Kline and coworkers concluded that the protective effect of this dietary composition was exerted by hydrated coconut oil in the composition due to the presence of lauric acid, the principle component in the oil . Hoch‐Ligeti reported that daily supplementation of fresh milk along with rice diet showed a protective effect on liver, for approximately 15 months of DAB administration . Remarkably, Sugiura and Rhoads reported the inhibitory action of various diets in DAB‐fed rats.…”

Section: Diet Composition and Its Influence On Tumor Incidencementioning

confidence: 99%

“…Compared with other strains, the tumor incidence in Wistar rats lagged for 4–6 weeks, and in Carworth Farms rats it was much slower . Hoch‐Ligeti reported that administration of DAB with a synthetic diet caused albino Wistar rats to develop liver, pancreatic, intestine, pituitary and skin (squamous or basal cell carcinoma or anaplastic carcinoma) tumors . Importantly, besides common strains some outbred strains like August, Donryu, Porton, Carworth Farms, Norwegian, Evans, Harlan, Sherman, Harvard and Blackhooded were also used for the investigation of DAB carcinogenesis.…”

Section: Diversity Of Tumorigenesis In Species and Target Organsmentioning

confidence: 99%

“…19 Hoch-Ligeti reported that administration of DAB with a synthetic diet caused albino Wistar rats to develop liver, pancreatic, intestine, pituitary and skin (squamous or basal cell carcinoma or anaplastic carcinoma) tumors. 20,21 Importantly, besides common strains some outbred strains like August, 22 Donryu, 23 Porton, 24 Carworth Farms, 19 Norwegian, 25 Evans, 17,19,26,27 Harlan, 19 Sherman, 17,18,28,29 Harvard 30 and Blackhooded 31 were also used for the investigation of DAB carcinogenesis. Although the tumor incidences of DAB in rats are extremely high, Sherman rats were generally more sensitive to DAB carcinogenesis than other strains.…”

Section: Diversity Of Tumorigenesis In Species and Target Organsmentioning

confidence: 99%

“…63 Hoch-Ligeti reported that daily supplementation of fresh milk along with rice diet showed a protective effect on liver, for approximately 15 months of DAB administration. 21,59 Remarkably, Sugiura and Rhoads reported the inhibitory action of various diets in DAB-fed rats. The reason for this is apparent; certain factors of a diet may control the development of liver cancer.…”

Section: Diet Composition and Its Influence On Tumor Incidencementioning

confidence: 99%

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Molecular aspects and chemoprevention of dimethylaminoazobenzene‐induced hepatocarcinogenesis: A review

Thomas

George

Nalini

2015

Hepatology Research

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The lipophilic azo dye dimethylaminoazobenzene (DAB) is a potent hepatocarcinogen accounted as a group-2B carcinogen causing risk to humans. DAB is commonly used as a coloring agent in food, pharmaceuticals, beverages, soap and polishes. The exploration of DAB-induced hepatocarcinogenesis in animal models helped to an extent to perceive the histological, biochemical and molecular mechanisms of DAB carcinogenesis and also the severity of DAB exposure to humans. In experimental animal models, it is well-proved that the procarcinogen DAB is predominantly metabolized by cytochrome P450 enzymes giving rise to the formation of toxic electrophiles and reactive oxygen species (ROS), which further forms DNA adducts leading to the development of hepatic tumors. Recently, research evidence suggests that dietary phytochemicals and plant polyphenols are promising agents to control the incidence of DAB-induced hepatocarcinogenesis by preventing the generation of toxic electrophiles and ROS thereby inhibiting the formation of DNA adducts. This review highlights the role of specific dietary factors, biotransformation of DAB, phenotypic and genotypic alterations, and significance of certain chemopreventive agents against DAB-induced hepatocarcinogenesis.

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Section: Diet Composition and Its Influence On Tumor Incidencementioning

confidence: 99%

Section: Diversity Of Tumorigenesis In Species and Target Organsmentioning

confidence: 99%

Section: Diversity Of Tumorigenesis In Species and Target Organsmentioning

confidence: 99%

Section: Diet Composition and Its Influence On Tumor Incidencementioning

confidence: 99%

See 2 more Smart Citations

Molecular aspects and chemoprevention of dimethylaminoazobenzene‐induced hepatocarcinogenesis: A review

Thomas

George

Nalini

2015

Hepatology Research

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“…There is evidence that superficial X-irradiation in repeated small doses throughout carcinogenesis may suppress liver tumour development (Hoch-Ligeti, 1949). Here the R.E.…”

mentioning

confidence: 97%