Effects of repeated treatments with an extract ofGinkgo biloba (EGb 761) and bilobalide on liver and muscle glycogen contents in the non-insulin-dependent diabetic rat

Rapin, J. R.; Yoa, René G.; Bouvier, Christine; Drieu, Katy

doi:10.1002/(sici)1098-2299(199701)40:1<68::aid-ddr7>3.0.co;2-r

Cited by 12 publications

(1 citation statement)

References 27 publications

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“…Compared with EGb 761, GBDP contains higher levels of flavonoids and terpene trilactones but lower levels of organic acids (Yu et al, 2021). GBE exerts an antidiabetic effect by elevating the glucose uptake rate (Rapin, Yoa, Bouvier, Drieu, & d. r., 1997), enhancing the function of pancreatic β‐cells (Kudolo, 2000), and increasing insulin sensitivity (Zhou, Meng, Qian, & Yang, 2011). Previously, we have shown that GBE can protect from hyperglycemia‐induced heart injuries via attenuating endoplasmic reticulum (ER) stress in a diabetic mouse model (Tian, Liu, Liu, Chen, & Lyu, 2018).…”

Section: Introductionmentioning

confidence: 99%

Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate‐activated protein kinase/mammalian target of the rapamycin pathway modulation

Yang

Zhao

Liu

et al. 2023

Phytotherapy Research

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Studies demonstrated that Ginkgo biloba extract (GBE) played a cardioprotective role in diabetic conditions. Impaired autophagy is one of the mechanisms underlying diabetic cardiomyopathy (DCM). The effect of GBE on autophagy has been observed in several diseases; however, whether GBE can ameliorate DCM by regulating autophagy remains unclear. Here, we investigated the effect of GBE on DCM and the potential mechanisms regarding autophagy using a streptozotocin (STZ)-induced diabetic rat model and a high-glucose (HG)-stimulated H9C2 cell model. We demonstrated that GBE attenuated metabolic disturbances, improved cardiac function, and reduced myocardial pathological changes in diabetic rats. Impaired autophagy as well as dysregulation of the adenosine monophosphate-activated protein kinase/ mammalian target of the rapamycin (AMPK/mTOR) signaling pathway were observed in diabetic hearts, as evidenced by the reduced conversion of LC3B-I to LC3B-II along with excessive p62 accumulation, decreased AMPK phosphorylation, and increased mTOR phosphorylation, which could be reversed by GBE treatment. In vitro, GBE reduced the apoptosis induced by HG in H9C2 cells by activating AMPK and inhibiting mTOR to restore autophagy. However, this effect was inhibited by the AMPK inhibitor Compound C. In conclusion, the ameliorative effect of GBE on DCM might be dependent on the restoration of autophagy through modulation of the AMPK/ mTOR pathway.

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Section: Introductionmentioning

confidence: 99%

Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate‐activated protein kinase/mammalian target of the rapamycin pathway modulation

Yang

Zhao

Liu

et al. 2023

Phytotherapy Research

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The effects of Ginkgo biloba on metabolic syndrome: A review

Eisvand

Razavi

Hosseinzadeh

2020

Phytotherapy Research

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The Ginkgo biloba (G. biloba), commonly known as ginkgo, brings considerable benefit to common medicine, including weight loss effects, as well as antidiabetic, antihypertensive, and antilipidemic properties that could be effective in the treatment of Metabolic syndrome (MetS) associated with increased risk of cardiovascular disease events. Major compounds of G. biloba are terpene lactones (bilobalide and ginkgolides A, B, and C) and flavone glycosides (isorhamnetin, quercetin, and kaempferol). We evaluated the most relevant original articles to indicate the effects of G. biloba on different components of MetS, including obesity, high blood pressure, dyslipidemia, and hyperglycemia. Several electronic databases (Scopus, PubMed, Web of Science and Google Scholar) were searched and the articles that included Ginkgo's effect on one or more of the criteria for MetS were selected. This review indicated that G. biloba might be efficient in the improvement of MetS; however, more studies especially clinical trials are needed to evaluate safety and efficacy of G. biloba.

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Ginkgo biloba

Ross¹

2001

Medicinal Plants of the World

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Effects of repeated treatments with an extract ofGinkgo biloba (EGb 761) and bilobalide on liver and muscle glycogen contents in the non-insulin-dependent diabetic rat

Cited by 12 publications

References 27 publications

Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate‐activated protein kinase/mammalian target of the rapamycin pathway modulation

Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate‐activated protein kinase/mammalian target of the rapamycin pathway modulation

The effects of Ginkgo biloba on metabolic syndrome: A review

Ginkgo biloba

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