Effects of Repeated Sublethal External Exposure to Deep Water Horizon Oil on the Avian Metabolome

Dorr, Brian S.; Hanson‐Dorr, Katie C.; Assadi‐Porter, Fariba M.; Selen, Ebru Selin; Healy, Katherine A.; Horak, Katherine E.

doi:10.1038/s41598-018-36688-3

Cited by 16 publications

(11 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple metabolic pathways associated with energy production were impaired in doublecrested cormorants dermally exposed to oil such that 20% of their surface area was lightly oiled (Dorr et al 2019). Both plasma and liver metabolomes were affected compared to controls indicating potential impacts to thermoregulation, cardiac function, and hematologic parameters.…”

Section: Fishmentioning

confidence: 97%

A review of the toxicology of oil in vertebrates: what we have learned following the Deepwater Horizon oil spill

Takeshita

Bursian

Colegrove

et al. 2021

Journal of Toxicology and Environmental Health, Part B

View full text Add to dashboard Cite

In the wake of the Deepwater Horizon (DWH) oil spill, a number of government agencies, academic institutions, consultants, and nonprofit organizations conducted lab-and field-based research to understand the toxic effects of the oil. Lab testing was performed with a variety of fish, birds, turtles, and vertebrate cell lines (as well as invertebrates); field biologists conducted observations on fish, birds, turtles, and marine mammals; and epidemiologists carried out observational studies in humans. Eight years after the spill, scientists and resource managers held a workshop to summarize the similarities and differences in the effects of DWH oil on vertebrate taxa and to identify remaining gaps in our understanding of oil toxicity in wildlife and humans, building upon the cross-taxonomic synthesis initiated during the Natural Resource Damage Assessment. Across the studies, consistency was found in the types of toxic response observed in the different organisms. Impairment of stress responses and adrenal gland function, cardiotoxicity, immune system dysfunction, disruption of blood cells and their function, effects on locomotion, and oxidative damage were observed across taxa. This consistency suggests conservation in the mechanisms of action and disease pathogenesis. From a toxicological perspective, a logical progression of impacts was noted: from molecular and cellular effects that manifest as organ dysfunction, to systemic effects that compromise fitness, growth, reproductive potential, and survival. From a clinical perspective, adverse health effects from DWH oil spill exposure formed a suite of signs/symptomatic responses that at the highest doses/concentrations resulted in multi-organ system failure.

show abstract

Section: Fishmentioning

confidence: 97%

A review of the toxicology of oil in vertebrates: what we have learned following the Deepwater Horizon oil spill

Takeshita

Bursian

Colegrove

et al. 2021

Journal of Toxicology and Environmental Health, Part B

View full text Add to dashboard Cite

show abstract

“…Dorr et al (2019) assessed the adverse effects of repeated, sublethal, external exposure of artificially weathered Deepwater Horizon (DWH) crude oil on metabolites extracted from the plasma and liver of Phalacrocorax auritus (Double‐crested Cormorants). 6.5 g of oil was applied to the backs and breasts (13 g total) of birds every 3 days throughout the 15‐day exposure period.…”

Section: Laboratory Studies On Effects Of Crude Oilsmentioning

confidence: 99%

Effects of pollution on marine organisms

Mearns

Morrison

Arthur³

et al. 2020

Water Environment Research

View full text Add to dashboard Cite

This review covers selected 2019 articles on the biological effects of pollutants, including human physical disturbances, on marine and estuarine plants, animals, ecosystems, and habitats. The review, based largely on journal articles, covers field, and laboratory measurement activities (bioaccumulation of contaminants, field assessment surveys, toxicity testing, and biomarkers) as well as pollution issues of current interest including endocrine disrupters, emerging contaminants, wastewater discharges, marine debris, dredging, and disposal. Special emphasis is placed on effects of oil spills and marine debris due largely to the 2010 Deepwater Horizon oil blowout in the Gulf of Mexico and proliferation of data on the assimilation and effects of marine debris microparticulates. Several topical areas reviewed in the past (e.g., mass mortalities ocean acidification) were dropped this year. The focus of this review is on effects, not on pollutant sources, chemistry, fate, or transport. There is considerable overlap across subject areas (e.g., some bioaccumulation data may be appeared in other topical categories such as effects of wastewater discharges, or biomarker studies appearing in oil toxicity literature). Therefore, we strongly urge readers to use keyword searching of the text and references to locate related but distributed information. Although nearly 400 papers are cited, these now represent a fraction of the literature on these subjects. Use this review mainly as a starting point. And please consult the original papers before citing them.

show abstract

“…In contrast, metabolomics studies have rarely been applied to the field of avian ecotoxicology, and have only focused on one of two species: chicken or double-crested cormorant [ 5 , 6 , 7 , 8 , 9 , 10 ]. These studies revealed that lipid metabolism was affected by exposure to perfluorooctanesulfonic acid, chromium, and alpha-cypermethrin in chickens [ 6 , 7 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages

et al. 2021

View full text Add to dashboard Cite

This proof-of-concept study characterizes the Japanese quail (Coturnix japonica) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.

show abstract

Effects of Repeated Sublethal External Exposure to Deep Water Horizon Oil on the Avian Metabolome

Cited by 16 publications

References 47 publications

A review of the toxicology of oil in vertebrates: what we have learned following the Deepwater Horizon oil spill

A review of the toxicology of oil in vertebrates: what we have learned following the Deepwater Horizon oil spill

Effects of pollution on marine organisms

Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages

Contact Info

Product

Resources

About