Effects of Repeated Sessions of Transcranial Direct Current Stimulation on Major Depressive Disorder and Cognition

Ninghetto, Marco; Gammeri, Roberto; Miccolis, Roberta; Nobili, Marcello; Salatino, Adriana; Ricci, Raffaella

doi:10.1097/yct.0000000000000611

Cited by 2 publications

(4 citation statements)

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“…This finding, together with the observation of increased anxiety (HAM-A) at follow-up, seem to suggest a negative effect of this treatment on the patient's mood and emotional state. This possibility is in line with the evidence that the application of the opposite (left anodal/ right cathodal) polarity to DLPFC is effective in treating depression and mood disorders (Ninghetto et al, 2019). Finally, this tDCS protocol did not affect patient's spatial attention consistent with previous evidence showing attention modulation by an opposite tDCS polarity (see for example Ninghetto et al, 2019, but also Sarasso et al, 2018.…”

Section: Discussionsupporting

confidence: 89%

“…This possibility is in line with the evidence that the application of the opposite (left anodal/ right cathodal) polarity to DLPFC is effective in treating depression and mood disorders (Ninghetto et al, 2019). Finally, this tDCS protocol did not affect patient's spatial attention consistent with previous evidence showing attention modulation by an opposite tDCS polarity (see for example Ninghetto et al, 2019, but also Sarasso et al, 2018. Importantly, the patient's overall cognitive decline was significantly improved by tDCS intervention.…”

Section: Discussionsupporting

confidence: 89%

“…During T1, T2 and T3, the patient completed three computerized tasks, measuring decision making and impulsivity: the Balloon Analogue Risk task (Bonini et al, 2018), the IOWA Gambling task (Li et al, 2010;Bechara et al, 1997), and a Go/No-go task (Bezdjian et al, 2009). Finally, since altered activity of dorsal prefrontal cortex may also affect spatial attention (Ninghetto et al, 2019;Ricci et al, 2012Ricci et al, , 2014, at each time point, the patient also performed a line bisection task (ten 20 cm long horizontal lines).…”

Section: Case Reportmentioning

confidence: 99%

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Improvement of Impulsivity and Decision Making by Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in a Patient with Gambling Disorder

et al. 2021

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Gambling disorder (GD) is a form of behavioral addiction. In recent years, it has been suggested that the application of transcranial Direct Current Stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC), which plays a key role in top-down inhibitory control and impulsivity, may represent a new therapeutic approach for treating addictions. Here we investigated the effectiveness of a novel low dose tDCS protocol (i.e. six sessions of right anodal/left cathodal tDCS for 20 min, with a current intensity of 1 mA) applied to DLPFC in a patient with GD. To evaluate the effect of the proposed intervention, cognitive, psychological and behavioural evaluations were performed at different time points, pre and post intervention. The results showed improvement of impulsivity, decision making, and cognitive functioning after tDCS intervention. Findings of the present study suggest that low doses of right anodal/left cathodal tDCS to DLPFC may effectively improve gambling behaviour. They also suggest to carefully evaluate the effects of this tDCS polarity on the patient’s emotional state. The current protocol warrants further investigation in large groups of patients, as it may provide relevant insights into the design of effective, low dose treatments of gambling disorder.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Case Reportmentioning

confidence: 99%

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Improvement of Impulsivity and Decision Making by Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in a Patient with Gambling Disorder

et al. 2021

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“…DLPFC is a region functionally connected to IFG [48]. It is well established that excitatory brain stimulation of left DLPFC and/or inhibitory brain stimulation of right DLPFC [49] are effective in treating depression and other mood disorders, manifesting among other symptoms, deficits in facial emotional perception [12]. However, these studies focus on dorsal regions of the prefrontal cortex.…”

Section: Discussionmentioning

confidence: 99%

Right and left inferior frontal opercula are involved in discriminating angry and sad facial expressions

et al. 2021

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Background: Neuroimaging studies suggest that the inferior frontal operculum (IFO) is part of a neuronal network involved in facial expression processing, but the causal role of this region in emotional face discrimination remains elusive. Objective: We used cathodal (inhibitory) tDCS to test whether right (r-IFO) and left (l-IFO) IFO play a role in discriminating basic facial emotions in healthy volunteers. Specifically, we tested if the two sites are selectively involved in the processing of facial expressions conveying high or low arousal emotions. Based on the Arousal Hypothesis we expected to find a modulation of high and low arousal emotions by cathodal tDCS of the r-IFO and the l-IFO, respectively. Methods: First, we validated an Emotional Faces Discrimination Task (EFDT). Then, we targeted the r-IFO and the l-IFO with cathodal tDCS (i.e. the cathode was placed over the right or left IFO, while the anode was placed over the contralateral supraorbital area) during facial emotions discrimination on the EFDT. Non-active (i.e. sham) tDCS was a control condition. Results: Overall, participants manifested the "happy face advantage". Interestingly, tDCS to r-IFO enhanced discrimination of faces expressing anger (a high arousal emotion), whereas, tDCS to l-IFO decreased discrimination of faces expressing sadness (a low arousal emotion). Conclusions: Our findings revealed a differential causal role of r-IFO and l-IFO in the discrimination of specific high and low arousal emotions. Crucially, these results suggest that cathodal tDCS might reduce the neural noise triggered by facial emotions, improving discrimination of high arousal emotions but disrupting discrimination of low arousal emotions. These findings offer new insights for treating clinical population with deficits in processing facial expressions.

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Effects of Repeated Sessions of Transcranial Direct Current Stimulation on Major Depressive Disorder and Cognition

Cited by 2 publications

References 5 publications

Improvement of Impulsivity and Decision Making by Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in a Patient with Gambling Disorder

Improvement of Impulsivity and Decision Making by Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in a Patient with Gambling Disorder

Right and left inferior frontal opercula are involved in discriminating angry and sad facial expressions

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