2004
DOI: 10.1016/j.tox.2004.06.047
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Effects of repeated ozone exposure on pulmonary function and bronchial responsiveness in mice sensitized with ovalbumin

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Cited by 11 publications
(7 citation statements)
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“…For atherosclerotic lesion assessment, apoEϪ/Ϫ mice were exposed to 0.5 ppm O3 or FA from 6 to 14 wk of age, 5 days/wk, 8 h/day (12 a.m. to 8 a.m.). This concentration is substantially lower than levels used in several previous studies (e.g., 1.0 -2.5 ppm) (15,27), and although still higher than both EPA National Ambient Air Quality Standard (NAAQS) (0.075 ppm) and OSHA permissible exposure limit (0.1 ppm) regulatory levels, mice are routinely recognized as less susceptible to O3 insult than humans due to obligatory nose breathing and other intrinsic factors (42). Thus, the employed exposure paradigm represents an approach useful for delineating potential pathobiological sequelae in humans.…”
Section: Methodsmentioning
confidence: 70%
“…For atherosclerotic lesion assessment, apoEϪ/Ϫ mice were exposed to 0.5 ppm O3 or FA from 6 to 14 wk of age, 5 days/wk, 8 h/day (12 a.m. to 8 a.m.). This concentration is substantially lower than levels used in several previous studies (e.g., 1.0 -2.5 ppm) (15,27), and although still higher than both EPA National Ambient Air Quality Standard (NAAQS) (0.075 ppm) and OSHA permissible exposure limit (0.1 ppm) regulatory levels, mice are routinely recognized as less susceptible to O3 insult than humans due to obligatory nose breathing and other intrinsic factors (42). Thus, the employed exposure paradigm represents an approach useful for delineating potential pathobiological sequelae in humans.…”
Section: Methodsmentioning
confidence: 70%
“…Using an asthmatic phenotype modeled by allergic sensitization of the respiratory tract, effects of O 3 on pulmonary function have been found to be augmented by allergic sensitization in infant rhesus monkeys (Fanucchi et al 2006; Joad et al 2006; Schelegle et al 2003), mice (Funabashi et al 2004), and rats (Wagner et al 2007). In addition, in a bleomycin-induced pulmonary fibrosis rat model, exposure to O 3 increased pulmonary inflammation and fibrosis, along with the frequency of bronchopneumonia (Oyarzún et al 2005).…”
Section: Resultsmentioning
confidence: 99%
“…Although there have been several similar mouse studies looking at the O 3 effects on the asthmatic inflammation [ 10 , 18 , 22 24 ], our work is unique in the animal protocol to mimic the real situation of O 3 -induced asthma exacerbation in human. It is worth to note that the concentration of O 3 used in this study (1.0 ppm) is relative higher than the atmosphere O 3 concentration (~0.01 ppm) for inducing a measurable biological response.…”
Section: Discussionmentioning
confidence: 99%