Effects of repeated nerve injuries at different time intervals on functional recovery and nerve innervation

Karasawa, Mika; Yokouchi, Kumiko; Kawagishi, Kyutaro; Moriizumi, Tetsuji; Fukushima, Nanae

doi:10.1016/j.jocn.2017.11.016

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…30 It has been reported that after repeated peripheral nerve injury by CL, the time from injury to the onset of regeneration is shortened, 31 and the rate of axonal outgrowth 32,33 and the number of regenerating axons 34 are increased. However, repeated crush injuries of peripheral nerves have been reported to reduce the rate of reinnervation and motor function recovery compared to a single crush injury, 8,35,36 and many aspects remain unclear.…”

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Effects of exercise on muscle reinnervation and plasticity of spinal circuits in rat sciatic nerve crush injury models with different numbers of crushes

et al. 2022

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Introduction/Aims: Motor function recovery is frequently poor after peripheral nerve injury. The effect of different numbers of nerve crushes and exercise on motor function recovery is unknown. We aimed to examine how different numbers of crushes of the rat sciatic nerve affects muscle reinnervation and plasticity of spinal circuits and the effect of exercise intervention.Methods: Single and multiple sciatic nerve crush models with different numbers of crushes were created in rats. Treadmill exercise was performed at 10 m/min for 60 min, five times a week. Muscle reinnervation and synaptic changes in L4-5 motor neurons were examined by immunofluorescence staining. Behavioral tests were the sciatic functional index (SFI) and the pinprick tests. Results:The percentage of soleus muscle reinnervation was not significantly increased by the presence of exercise in single or multiple crushes. Exercise after a single crush increased the contact of motor neurons with VGLUT1-containing structures (Exercised vs. Unexercised, 12.9% vs. 8.7%; p < .01), but after multiple crushes, it decreased with or without exercise (8.1% vs. 8.6%). Exercise after a single crush significantly improved SFI values from 14 to 24 days, and exercise after multiple crushes from 21 to 35 days (all p < .05). The pinprick test showed no difference in recovery depending on the number of crushes or whether or not exercised.Discussion: Different numbers of sciatic nerve crushes affect muscle reinnervation and motor neuron synaptic changes differently, but motor function recovery may improve with exercise regardless of the number of crushes.

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Effects of exercise on muscle reinnervation and plasticity of spinal circuits in rat sciatic nerve crush injury models with different numbers of crushes

et al. 2022

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Serious Complications of Regional Anaesthesia

Kerr

Brull

Macfarlane

2022

Regional Nerve Blocks in Anesthesia and Pain Therapy

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The weepy cry – short neural signal bursts in intraoperative neuromonitoring

Munk,

Merkelbach,

Lamadé

2024

Langenbecks Arch Surg

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Purpose This study aimed to establish an in-vitro alternative to existing in-vivo systems to analyze nerve dysfunction using continuous neuromonitoring (C-IONM). Methods Three hundred sixty-three recurrent laryngeal nerves (RLN) (N(pigs) = 304, N(cattle) = 59) from food industry cadavers were exposed by microsurgical dissection following euthanasia. After rinsing with Ringer's lactate, they were tempered at 22 °C. Signal evaluation using C-IONM was performed for 10 min at 2 min intervals, and traction forces of up to 2N were applied for a median time of 60 s. Based on their post-traumatic electrophysiological response, RLNs were classified into four groups: Group A: Amplitude ≥ 100%, Group B: loss of function (LOS) 0–25%, Group C: ≥ 25–50%, and Group D: > 50%. Results A viable in-vitro neuromonitoring system was established. The median post-traumatic amplitudes were 112%, 88%, 59%, and 9% in groups A, B, C, and D, respectively. A time-dependent further dynamic LOS was observed during the 10 min after cessation of strain. Surprisingly, following initial post-traumatic hyperconductivity, complete LOS occurred in up to 20% of the nerves in group A. The critical threshold for triggering LOS was 2N in all four groups, resulting in immediate paralysis of up to 51.4% of the nerves studied. Conclusion Consistent with in-vivo studies, RLN exhibit significant intrinsic electrophysiological variability in response to tensile forces. Moreover, nerve damage progresses even after the complete cessation of strain. Up to 20% of nerves with transiently increased post-traumatic amplitudes above 100% developed complete LOS, which we termed the "weepy cry." This time-delayed response must be considered during the interpretation of C-IONM signals.

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Effects of repeated nerve injuries at different time intervals on functional recovery and nerve innervation

Cited by 4 publications

References 14 publications

Effects of exercise on muscle reinnervation and plasticity of spinal circuits in rat sciatic nerve crush injury models with different numbers of crushes

Effects of exercise on muscle reinnervation and plasticity of spinal circuits in rat sciatic nerve crush injury models with different numbers of crushes

Serious Complications of Regional Anaesthesia

The weepy cry – short neural signal bursts in intraoperative neuromonitoring

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