Effects of repeated extracorporeal shock wave in urinary biochemical markers of rats

Carvalho, Marcio; Filho, Luiz Gonzaga de Freitas; Carvalho, Maurício; Fagundes, Djalma José; Ortiz, Valdemar

doi:10.1590/s0102-86502009000600013

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…Applied the number of shock waves and the level of energy were decided based on previous studies and our preliminary studies. 15,16 After SWT procedure, rats were returned to their cages.…”

Section: Swt Proceduresmentioning

confidence: 99%

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Fırat¹,

Malkoç

Demirer³

et al. 2014

Renal Failure

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Objectives: Shock wave lithotripsy treatment (SWT) is not completely free from side effects; one of the accused mechanisms for renal injury during SWT is oxygen-and nitrogen-derived free radical productions. Therefore, we aimed to evaluate the effect of inhibition of nitric oxide (NO) production by N-[3(aminomethyl) benzyl) acetamidine] (1400W), highly selective inducible nitric oxide synthase (iNOS) inhibitor, at SWT-induced kidney damage. Materials and methods: Twenty-four rats those underwent right nephrectomy procedure were divided equally into three groups as control, SWT, and SWT + 1400W. 1400W was administered at a dose of 10 mg/kg at 2 h prior to SWT procedure and at the beginning of SWT procedure via intraperitoneal route and continued daily for consecutive 3 days. At the end of the fourth day, animals were killed via decapitation and trunk blood and the left kidneys were taken for biochemical and histopathologic evaluation. Results: SWT caused renal tubular damage and increased lipid peroxidation and antioxidant enzyme activities and SWT also significantly increased nitro-oxidative products. Inhibition of iNOS via administration of 1400W ameliorated renal injury and decreased tissue lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase and nitrite/nitrate levels (NO x ). In addition, it was seen that histolopathological changes were attenuated in the SWT + 1400W group when compared to SWT group. Conclusion: SWT-induced renal injury might be due to excessive production of oxygen free radicals and NO production. Inhibition of iNOS attenuates renal injury following SWT treatment. It can be concluded that iNOS inhibitors or peroxynitrite scavengers might be used to protect the kidneys against SWT-induced morphological and functional injuries.

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“…Applied the number of shock waves and the level of energy were decided based on previous studies and our preliminary studies. 15,16 After SWT procedure, rats were returned to their cages.…”

Section: Swt Proceduresmentioning

confidence: 99%

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Fırat¹,

Malkoç

Demirer³

et al. 2014

Renal Failure

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“…Applied the number of shock waves and the level of energy were decided based on previous studies and our preliminary studies. [14][15][16][17] After ESW procedure, rats were returned to their cages.…”

Section: Induction Of Esw-induced Renal Injurymentioning

confidence: 99%

Efficacy of poly(adenosine diphosphate-ribose) polymerase inhibition in extracorporeal shock wave-induced renal injury

Malkoç

Fırat²,

Demirer

et al. 2014

Renal Failure

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Objectives: Extracorporeal shock wave lithotripsy (ESW) induces renal damage by excessive production of free oxygen radicals. Free Oxygen radicals cause cellular injury by inducing nicks in DNA. The enzyme poly(adenosine diphosphate-ribose) polymerase (PARP) involved in the process of repair of DNA in damaged cells. However, its activation in damaged cells can lead to adenosine triphosphate depletion and death. Thus, we designed a study to evaluate the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, against extracorporeal shock wave induced renal injury. Methods: Twenty-four Sprague-Dawley rats were divided into three groups: control, ESW, ESW + 3-AB groups. All groups except control group were subjected to ESW procedure. ESW + 3-AB group received 20 mg/kg/day 3-aminobenzamide intraperitoneally at 2 h before ESW and continued once a day for consecutive 3 days. The surviving animals were sacrificed at the 4th day and their kidneys were harvested for biochemical and histopathologic analysis. Blood samples from animals were also obtained. Results: Serum ALT and AST levels, serum neopterin and tissue oxidative stress parameters were increased in the ESW group and almost came to control values in the treatment group (p50.05, ESW vs. ESW + 3-AB). Histopathological injury score were significantly lower in treatment group than the ESW group (p50.05, ESW vs. ESW + 3-AB). Conclusion: Our data showed that PARP inhibition protected renal tissue against ESW induced renal injury. These findings suggest that it would be possible to improve the outcome of ESW induced renal injury by using PARP inhibitors as a preventive therapy.

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“…Carvalho et al [ 31 ] aimed to show the effect of repeated ESWL on urinary biochemical markers on the animal model study. Twenty rats were assigned for ESWL to one of the two groups: single ESW and double ESW in a 14-day interval.…”

Section: Resultsmentioning

confidence: 99%

Evaluation and physiopathology of minor transient shock wave lithotripsy – induced renal injury based on urinary biomarkers levels

Dzięgała

Krajewski

Kołodziej

et al. 2018

CEJU

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IntroductionExtracorporeal shock wave lithotripsy (ESWL) is one of the most useful methods available for the treatment of urolithiasis. However, despite its significant benefits, adverse effects can occur. Oxidative stress mediated by ischemia-reperfusion might contribute to kidney injury after ESWL. Moreover, an acute kidney injury (AKI) may develop. AKI is typically diagnosed by measuring serum creatinine level, yet serum creatinine does not allow for early detection of sub-clinical AKI. The latest report has investigated multiple ways to determine ESWL – induced renal damage through the evaluation of various urine biomarkers of renal injury.Materials and methodsThe Medline and Web of Science databases were searched without a time limit in November 2017 using the terms ‘ESWL’ in conjunction with ‘kidney failure’, ‘kidney damage’, ‘renal injury’ and ‘inflammation markers’, ’biomarkers’. Boolean operators (NOT, AND, OR) were also used in succession to narrow and broaden the search. In this review, we described all the up-to-date reported urine markers of ESWL-induced renal damage.ResultsIn recent years, several studies demonstrated evaluation of ESWL – induced renal injury based on urinary biomarkers levels and its utility in clinical practice. They have a beneficial role in the early detection of AKI, as well as in observation of a transition of this acute illness into chronic kidney disease.ConclusionsDifferent markers have been evaluated in the urine before and after the ESWL treatment, but their number is still limited and results remain inconclusive. Further investigations are mandatory.

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Effects of repeated extracorporeal shock wave in urinary biochemical markers of rats

Cited by 6 publications

References 37 publications

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Efficacy of poly(adenosine diphosphate-ribose) polymerase inhibition in extracorporeal shock wave-induced renal injury

Evaluation and physiopathology of minor transient shock wave lithotripsy – induced renal injury based on urinary biomarkers levels

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