Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model

Kanbak, Orhan; Aydogan, Burcu; Gümüş, Tülin

doi:10.1515/med-2021-0381

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…[18], they showed that in patients undergoing anaesthesia induction with propofol and thiopental, propofol inhibited the cellular oxidative damage measured in platelets and glutathione increased antioxidant defence. In the study of Kanbak et al (19), histological examination showed that propofol reduced the negative effects of I/R on tissues, while remifentanil was not as effective as propofol.…”

Section: Discussion Conclusionmentioning

confidence: 96%

The effects of anaesthetic induction with propofol or thiopental on oxidative stress parameters in patients undergoing laparoscopic cholecystectomy surgery

ÇELİKSU

Aksoy

Özcan³

2023

Preprint

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The aim of this study is to find out which of the uses – propofol or thiopental – in the anaesthetic induction in the events of laparoscopic cholecystectomy could have a more positive effect on oxidative stress and to investigate the relation between the events’ haemodynamic parameter variables and oxidative stress. Planned as randomized and prospective, our study was carried out with 60 patients in the operating theatre of Ankara Atatürk Training and Research Hospital. Patients were randomly divided into two equal groups. In the anesthetic induction of the patients, in Group 1 thiopental 4-7 mg/kg iv and in Group 2 propofol 2-3 mg/kg iv were used. The other drugs used were the same. Hemodynamic data were recorded at designated times. To measure serum thiol-disulphide, TAS (total antioxidant status), TOS (total oxidant status), PON1 (paraoxonase) and ARES (arylesterase) levels, blood was drawn from the patients two times – one being before the general anesthesia induction and the other in the recovery room.While the thiol levels that include TOS, ARES and SH are affected similarly in both groups, TAS levels were found to be unchanged in thiopental group but to increase in propofol group, and PON1 level was found to be unchanged in propofol group and to decrease in thiopental group. Moreover, when the patients whose anesthesia ended in the morning and in the afternoon were studied within themselves in terms of changes in the oxidative stress parameters before and after operation, determination of the fact that there was a meaningful increase in the post-operative TAS values of patients whose anesthesia ended in the morning and that there was a more meaningful decrease in post-operative PON1, ARES and thiol levels in patients whose anesthesia ended in the afternoon gave rise to the thought that oxidative stress was higher in the afternoon. In our study, a positive correlation between post-operative TAS, PON1 and ARES and general blood pressure values; between post-operative TOS values and KAH values in induction; between ETCO2 values on the fifth minute of the operation and TOS values; between ARES value and post-extubation SpO2 and a negative correlation between PON1 and ARES values and KAH values were determined. In our study, we concluded that propofol would be a preferable iv anesthetic agent as it caused an increase in TAS level. Furthermore, in our study it was decided that we needed to avoid conditions such as hypertension, uncontrolled hypotension, tachycardia, hypercapnia, and hypoxia to reduce the oxidative stress.

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Section: Discussion Conclusionmentioning

confidence: 96%

The effects of anaesthetic induction with propofol or thiopental on oxidative stress parameters in patients undergoing laparoscopic cholecystectomy surgery

ÇELİKSU

Aksoy

Özcan³

2023

Preprint

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Targeting the opioid remifentanil: Protective effects and molecular mechanisms against organ ischemia-reperfusion injury

Yi,

Cao,

Zheng

et al. 2023

Biomedicine & Pharmacotherapy

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Possible protective effect of remifentanil against testicular ischemia-reperfusion injury

Kölükçü,

Unsal,

Katar

et al. 2024

Turkish Journal of Biochemistry

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Objectives This study aims to evaluate the protective efficacy of remifentanil against testicular ischemia-reperfusion injury. Methods The study included 24 male rats. The rats were randomized into three groups: Group 1 was the control group. Group 2 was subjected to a testicular torsion/detorsion model. Group 3 underwent similar procedures and additionally received remifentanil (0.6 μg/kg/min) intravenously for the first 20 min of reperfusion. Blood samples were taken for biochemical analyses, and orchiectomy was performed for histopathologic examination. Results Biochemical analysis of blood samples showed a significant increase in antioxidant enzyme activity, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in Group 3 compared to Group 2 (p:0.004 and p:0.002, respectively). There was a dramatic decrease in the levels of proinflammatory cytokines, including interleukin-1 beta (IL-1 Beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in Group 3 compared to Group 2 (p:0.001, p:0.046, and p:0.004, respectively). Similarly, malondialdehyde (MDA) levels decreased in Group 3 compared to Group 2 (p:0.004). Histopathologic examination of Group 3 rats showed positive changes in inflammation, hemorrhage, edema, and congestion levels compared to Group 2 (p<0.001). Similarly, there was a positive effect on the Johnsen and Cosentino score in Group 3 compared to Group 2 (p:0.001 and p<0.001, respectively). Conclusions In our study, it has been documented that remifentanil protects against testicular ischemia-reperfusion injury.

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Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model

Cited by 4 publications

References 36 publications

The effects of anaesthetic induction with propofol or thiopental on oxidative stress parameters in patients undergoing laparoscopic cholecystectomy surgery

The effects of anaesthetic induction with propofol or thiopental on oxidative stress parameters in patients undergoing laparoscopic cholecystectomy surgery

Targeting the opioid remifentanil: Protective effects and molecular mechanisms against organ ischemia-reperfusion injury

Possible protective effect of remifentanil against testicular ischemia-reperfusion injury

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