Effects of regular exercise on inflammasome activation-related inflammatory cytokine levels in older adults: a systematic review and meta-analysis

Yi, Ding; Xu, Xi

doi:10.1080/02640414.2021.1932279

Cited by 15 publications

(14 citation statements)

References 64 publications

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“…Exercise reduces the NLR family pyrin domain containing 3 (NLRP3) inflammasome, a key component of the innate immune system that initiates caspase-1 activation, which is an inflammatory form of cell death and the release of pro-inflammatory cytokines IL-1β and IL-18 ( Quiroga et al, 2020 ; Ding and Xu, 2021 ). It was recommended that aerobic exercise is the most effective training modality, and low-to-moderate intensity and mixed intensity are better compared with high intensity to decrease NLRP3 inflammasome activation-related inflammatory cytokine IL-1β and IL-18 ( Ding and Xu, 2021 ).…”

Section: Anti-inflammatory Signaling Pathways Of Moderate Intensity Exercisementioning

confidence: 99%

Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects

2021

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The coronavirus disease (COVID-19) pandemic is caused by a novel coronavirus (CoV) named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As the angiotensin converting enzyme 2 (ACE2) is the cellular receptor of SARS-CoV-2, it has a strong interaction with the renin angiotensin system (RAS). Experimental studies have shown that the higher levels of ACE2 or increasing ACE2/ACE1 ratio improve COVID-19 outcomes through lowering inflammation and death. Aerobic moderate intensity physical exercise fights off infections by two mechanisms, the inhibition of ACE/Ang II/AT1-R pathway and the stimulation of ACE2/Ang-(1–7)/MasR axis. Exercise can also activate the anti-inflammatory response so that it can be a potential therapeutic strategy against COVID-19. Here, we summarize and focus the relation among COVID-19, RAS, and immune system and describe the potential effect of aerobic moderate intensity physical exercise against CoV as a useful complementary tool for providing immune protection against SARS-CoV-2 virus infection, which is a novel intervention that requires further investigation.

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Section: Anti-inflammatory Signaling Pathways Of Moderate Intensity Exercisementioning

confidence: 99%

Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects

2021

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“…A recent systematic review and meta‐analysis of 19 randomized controlled trials investigating the effect of regular exercise on inflammatory cytokine response found that regular moderate exercise may exert its anti‐inflammatory effect by reducing the levels of inflammasome activation‐related cytokines (IL‐1β and IL‐18) 23 …”

Section: Infection‐like Syndromes In Athletes—when No Pathogen Can Be...mentioning

confidence: 99%

Physical exercise, immune response, and susceptibility to infections—current knowledge and growing research areas

Kurowski

Seys

Bonini

et al. 2022

Allergy

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This review presents state-of-the-art knowledge and identifies knowledge gaps for future research in the area of exercise-associated modifications of infection susceptibility. Regular moderate-intensity exercise is believed to have beneficial effects on immune health through lowering inflammation intensity and reducing susceptibility to respiratory infections. However, strenuous exercise, as performed by professional athletes, may promote infection: in about half of athletes presenting respiratory symptoms, no causative pathogen can be identified. Acute bouts of exercise enhance the release of pro-inflammatory mediators, which may induce infection-like respiratory symptoms. Relatively few studies have assessed the influence of regularly repeated exercise on the immune response and systemic inflammation compared to the effects of acute exercise. Additionally, ambient and environmental conditions may modify the systemic inflammatory response and infection susceptibility, particularly in outdoor athletes. Both acute and chronic regular exercise influence humoral and cellular immune response mechanisms, resulting in decreased specific and non-specific response in competitive athletes. The most promising areas of further research in

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“…Regular exercise induces interleukin-6 (IL-6) produced by muscle fibers, which stimulates anti-inflammatory cytokines (IL-1ra and IL-10) and inhibits tumor necrosis alpha (TNF-α) [ 100 ]. In a recent systematic review and meta-analysis, regular exercise decreased aging-induced inflammasome activation related to inflammatory cytokines (IL-1β and IL-18) [ 101 ]. In exercised (voluntary free-wheel running) mice fed a high-fat diet, exercise suppressed the pyrin domain of the NOD-like receptor family containing the 3 (NLRP3) inflammasome, improved nitric oxide production, and reduced oxidative stress [ 102 ].…”

Section: Exercisementioning

confidence: 99%

“…Abbreviations: ↑ = increase, ↓ = decrease, MI = Myocardial Infarction, VEGF = vascular endothelial growth factor, TNF-α = tumor necrosis factor alpha, IL-1β = interleukin1-beta, IL-6 = interleukin 6, IL-17 = interleukin 17, IL-10 = interleukin 10, IL1-ra = interleukin 1 receptor antagonist, MCP-1 = Monocyte Chemoattractant Protein-1, sVCAM-1 = soluble Vascular Cell Adhesion Molecule-1, TIE2 = endothelial-specific receptor tyrosine kinase family, eNOS = endothelial derived nitric oxide synthase, NFƙβ-p65 = nuclear factor kappa beta p65 subunit, VF = ventricular fibrillation, LVEF = left ventricular ejection fraction, EF = Ejection Fraction. [ 100 , 101 , 102 , 103 , 114 , 115 , 116 , 117 , 121 , 122 , 125 , 126 , 128 , 129 , 133 , 134 , 138 , 139 , 140 , 141 , 143 , 160 , 161 , 162 , 166 , 172 , 175 , 177 , 178 , 179 , 182 , 183 , 184 , 185 , 186 , 188 , 189 ].…”

Section: Figurementioning

confidence: 99%

Non-Invasive Pulsatile Shear Stress Modifies Endothelial Activation; A Narrative Review

2022

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The monolayer of cells that line both the heart and the entire vasculature is the endothelial cell (EC). These cells respond to external and internal signals, producing a wide array of primary or secondary messengers involved in coagulation, vascular tone, inflammation, and cell-to-cell signaling. Endothelial cell activation is the process by which EC changes from a quiescent cell phenotype, which maintains cellular integrity, antithrombotic, and anti-inflammatory properties, to a phenotype that is prothrombotic, pro-inflammatory, and permeable, in addition to repair and leukocyte trafficking at the site of injury or infection. Pathological activation of EC leads to increased vascular permeability, thrombosis, and an uncontrolled inflammatory response that leads to endothelial dysfunction. This pathological activation can be observed during ischemia reperfusion injury (IRI) and sepsis. Shear stress (SS) and pulsatile shear stress (PSS) are produced by mechanical frictional forces of blood flow and contraction of the heart, respectively, and are well-known mechanical signals that affect EC function, morphology, and gene expression. PSS promotes EC homeostasis and cardiovascular health. The archetype of inducing PSS is exercise (i.e., jogging, which introduces pulsations to the body as a function of the foot striking the pavement), or mechanical devices which induce external pulsations to the body (Enhanced External Pulsation (EECP), Whole-body vibration (WBV), and Whole-body periodic acceleration (WBPA aka pGz)). The purpose of this narrative review is to focus on the aforementioned noninvasive methods to increase PSS, review how each of these modify specific diseases that have been shown to induce endothelial activation and microcirculatory dysfunction (Ischemia reperfusion injury-myocardial infarction and cardiac arrest and resuscitation), sepsis, and lipopolysaccharide-induced sepsis syndrome (LPS)), and review current evidence and insight into how each may modify endothelial activation and how these may be beneficial in the acute and chronic setting of endothelial activation and microvascular dysfunction.

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Effects of regular exercise on inflammasome activation-related inflammatory cytokine levels in older adults: a systematic review and meta-analysis

Cited by 15 publications

References 64 publications

Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects

Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects

Physical exercise, immune response, and susceptibility to infections—current knowledge and growing research areas

Non-Invasive Pulsatile Shear Stress Modifies Endothelial Activation; A Narrative Review

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