Effects of refeeding by cyclic enteral nutrition on body composition: comparative study of elderly and younger patients

Hébuterne, Xavier; Schneider, S.; Peroux, J.-L.; Rampal, Patrick

doi:10.1016/s0261-5614(97)80013-1

Cited by 46 publications

(18 citation statements)

References 27 publications

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“…However, using dietary protein depletion to induce a decrease in muscle mass, Carter and Lynch (5) showed that hindlimb muscle mass was still unchanged compared with depleted animals after 3 wk of protein refeeding in 24-mo-old rats, whereas it was significantly higher in 3-mo-old rats. An age-related impaired capacity to recover muscle mass lost during catabolic periods has also been described in humans (14).…”

Section: Discussionmentioning

confidence: 96%

“…Sarcopenia could result from an altered capacity of older individuals to recover muscle proteins lost during catabolic periods. Indeed, refed, undernourished patients aged over 65 yr have been shown to have a lower fat-free mass recovery than those under 65 yr (14). This lower recovery is probably related to a lower stimulation of protein synthesis and/or a lower inhibition of proteolysis during refeeding; these changes are likely to be more easily detected than those involved in the gradual decrease in muscle protein mass (they are probably similar).…”

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confidence: 99%

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Lower recovery of muscle protein lost during starvation in old rats despite a stimulation of protein synthesis

Mosoni

Malmezat

Valluy

et al. 1999

American Journal of Physiology-Endocrinology and Metabolism

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Sarcopenia could result from the inability of an older individual to recover muscle lost during catabolic periods. To test this hypothesis, we compared the capacity of 5-day-refed 12- and 24-mo-old rats to recover muscle mass lost after 10 days without food. We measured gastrocnemius and liver protein synthesis with the flooding-dose method and also measured nitrogen balance, 3-methylhistidine excretion, and the gene expression of components of proteolytic pathways in muscle comparing fed, starved, and refed rats at each age. We show that 24-mo-old rats had an altered capacity to recover muscle proteins. Muscle protein synthesis, inhibited during starvation, returned to control values during refeeding in both age groups. The lower recovery in 24-mo-old rats was related to a lack of inhibition of muscle proteolysis during refeeding. The level of gene expression of components of the proteolytic pathways did not account for the variations in muscle proteolysis at both ages. In conclusion, this study highlights the role of muscle proteolysis in the lower recovery of muscle protein mass lost during catabolic periods.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Lower recovery of muscle protein lost during starvation in old rats despite a stimulation of protein synthesis

Mosoni

Malmezat

Valluy

et al. 1999

American Journal of Physiology-Endocrinology and Metabolism

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“…Indeed it is important to remember that the features of malnutrition, for example apathy, weakness and impaired immunity increase morbidity and reduce the quality of life. Furthermore, nutritional depletion takes a long time to recover -more so in the elderly 12 .…”

Section: Nutritional Depletionmentioning

confidence: 99%

To PEG or not to PEG

Pennington

2002

Clinical Medicine

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-Patients with adequate intestinal function who are unable to eat may benefit from enteral tube feeding. Percutaneous endoscopic gastrostomy (PEG) is preferred when prolonged treatment is envisaged. PEG feeding will reduce morbidity and mortality in many such patients by reversing malnutrition. The increasing numbers of elderly patients with chronic diseases have resulted in an increased demand for PEG placement that has stretched resources. Many patients who are referred for PEGs are frail and the procedure is associated with complications. Careful management and support for the carers in the community are essential. Not all patients benefit from PEG feeding. The aim must be an improvement in the quality of life, not a prolongation of terminal disease.

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“…Moreover, the potential to recover muscle mass after an atrophy-inducing event, such as bed rest or malnutrition, is reduced in aged subjects, putting them at a greater risk for falls and subsequent illnesses (Hebuterne et al, 1997; Hvid et al, 2010; Suetta et al, 2009). English and Paddon-Jones have proposed the catabolic crisis model in which the age-related inability to recover muscle mass contributes to the decrease in functional capacity (English and Paddon-Jones, 2010).…”

Section: Introductionmentioning

confidence: 99%

Regrowth after skeletal muscle atrophy is impaired in aged rats, despite similar responses in signaling pathways

White

Confides

Moore

et al. 2015

Experimental Gerontology

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Skeletal muscle regrowth after atrophy is impaired in the aged and in this study we hypothesized that this can be explained by a blunted response of signaling pathways and cellular processes during reloading after hind limb suspension in muscles from old rats. Male Brown Norway Fisher 344 rats at 6 (young) and 32 (old) months of age were subjected to normal ambulatory conditions (amb), hind limb suspension for 14 days (HS), and HS followed by reloading through normal ambulation for 14 days (RE); soleus muscles were used for analysis of intracellular signaling pathways and cellular processes. Soleus muscle regrowth was blunted in old compared to young rats which coincided with a recovery of serum IGF-1 and IGFBP-3 levels in young but not old. However, the response to reloading for p-Akt, p-p70s6k and p-GSK3β protein abundance was similar between muscles from young and old rats, even though main effects for age indicate an increase in activation of this protein synthesis pathway in the aged. Similarly, MAFbx mRNA levels in soleus muscle from old rats recovered to the same extent as in the young, while Murf-1 was unchanged. mRNA abundance of autophagy markers Atg5 and Atg7 showed an identical response in muscle from old compared to young rats, but beclin did not. Autophagic flux was not changed at either age at the measured time point. Apoptosis was elevated in soleus muscle from old rats particularly with HS, but recovered in HSRE and these changes were not associated with differences in caspase-3, -8 or-9 activity in any group. Protein abundance of apoptosis repressor with caspase-recruitment domain (ARC), cytosolic EndoG, as well as cytosolic and nuclear apoptosis inducing factor (AIF) were lower in muscle from old rats, and there was no age-related difference in the response to atrophy or regrowth. Soleus muscles from old rats had a higher number of ED2 positive macrophages in all groups and these decreased with HS, but recovered in HSRE in the old, while no changes were observed in the young. Pro-inflammatory cytokines in serum did not show a differential response with age to different loading conditions. Results indicate that at the measured time point the impaired skeletal muscle regrowth after atrophy in aged animals is not associated with a general lack of responsiveness to changes in loading conditions.

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Effects of refeeding by cyclic enteral nutrition on body composition: comparative study of elderly and younger patients

Cited by 46 publications

References 27 publications

Lower recovery of muscle protein lost during starvation in old rats despite a stimulation of protein synthesis

Lower recovery of muscle protein lost during starvation in old rats despite a stimulation of protein synthesis

To PEG or not to PEG

Regrowth after skeletal muscle atrophy is impaired in aged rats, despite similar responses in signaling pathways

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