Effects of redox cycling compounds on glutathione content and activity of glutathione-related enzymes in rainbow trout liver

Stephensen, Eiríkur; Sturve, Joachim; Förlin, Lars

doi:10.1016/s1532-0456(02)00129-1

Cited by 116 publications

(108 citation statements)

References 37 publications

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“…The role of GR is to maintain the cytosolic concentration of GSH. The mechanism of regulation of GR activity in fish is still unknown; however, the content of GSSG was supposed to be a critical factor in the induction of GR activity in rainbow trout liver (Stephensen et al, 2002). In the present study, GR activity was induced, in response to the enhanced GSSG content at 100 lg l À1 , which confirmed the former suggestion.…”

Section: Gsh and Gsh-related Enzymes In Brainsupporting

confidence: 90%

Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

2006

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Section: Gsh and Gsh-related Enzymes In Brainsupporting

confidence: 90%

Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

2006

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“…GSH is a tripeptide that consists of g-glutamine, cysteine, and glycine, and is responsible for maintaining the redox status of the cells. It reacts directly with ROS and electrophilic compounds, and, protects cells against toxicity [40]. The decreased GSH content, which indicates the oxidative stress that was observed in the present study, might be a result of ROS production [45].…”

Section: Discussionmentioning

confidence: 47%

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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In this study, isolated hepatocytes of pearl mullet (Alburnus tarichi) were exposed to bisphenol A (BPA) at concentrations of 25, 50, 100, and 200 µM for 24 h. Moreover, an in vitro antioxidant concentration of vitamin C (50 µM) was administrated to the culture medium along with the BPA exposures. Next, the antioxidant defense system parameters were analyzed. According to the results, the highest concentration of BPA (200 µM) proved to be severely toxic for the cells. The increased activities of superoxide dismutase (SOD) and glutathione-S-transferase (GST), the fluctuated activities of glutathione peroxidase (GPx), and the decreased content of reduced glutathione (GSH) were compared to the control group after the BPA exposures. Vitamin C co-administration was found to cause further increases in the SOD, GPx, and GST activities in some of the experimental groups and vitamin C could not restore the GSH content. Malondialdehyde (MDA) levels were observed to be unaffected in all exposure groups. These results show that BPA causes alterations in the antioxidant defenses of the isolated fish hepatocytes. In addition, vitamin C co-administration along with BPA was found to be non-protective against BPA-induced oxidative stress, consequently, aggravated a negative BPA impact.

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“…Paraquat'ın Yılanbaş (Channa punctata) [68], Zebra balığı (Danio rerio) [69] ve Gökkuşağı alabalığı'nda [70] oksidatif stresi artırdığı rapor edilmiştir. Benzer şekilde, diquat, sazan karaciğer hücrelerinde [71] ve gökkuşağı alabalığının solungaç dokularında [72] ROT üretimini uyarmıştır.…”

Section: Herbisitlerunclassified

Sucul Organizmalarda Çevresel Şartlara Karşı Geliştirilen Oksidatif Stres Mekanizmaları ve Adaptif Yanıtlar

Kayhan¹,

Kaymak²,

Akbulut³

et al. 2015

MUFBED

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ÖzetSucul ekosistemlerdeki kirlilik, ciddi ve artan bir problemdir. Endüstriyel, tarımsal ve ticari kimyasalların yüksek oranda sucul çevreye deşarj edilmesi sucul canlılarda çeşitli zararlı etkilere neden olur. Biyolojik sistemlerde oksidatif stres, reaktif oksijen türlerini (ROT) artırarak veya antioksidan savunma sistemlerine hasar vererek oluşur. Balıklardaki oksidatif stresin neden olduğu biyokimyasal ve fizyolojik hasarlar, stresin şiddetine, mekanizmasına ve antioksidan enzim aktivitesine bağlıdır. Bu derlemede, sucul organizmaların çevresel şartlara karşı geliştirdikleri oksidatif stres ve adaptif yanıtların incelendiği çalışmalar ele alınmıştır.Anahtar Kelimeler: Oksidatif Stres, Sucul Organizmalar, Çevre Kirliliği Oxidative Stress Mechanisms and Adaptive Responses in Aquatic Organisms Against to Environmental Conditions AbstractPollution of the aquatic ecosystems is a serious and evergrowing problem. Increasing amount of industrial, agricultural and commercial chemicals discharges into the aquatic environment have led to various harmful effects on the aquatic organisms. Oxidative stress is caused through damaged biological systems via producing Reactive Oxigen Species (ROS) or by impairing antioxidant defense systems. Biochemical and physiological damages caused by oxidative stress in fish depend on antioxidant enzyme activities, stress intensity and its mechanism. This paper reviews the studies on oxidative stress developed by aquatic organisms against environmental conditions and their adaptive responses.Keywords: Oxidative Stress, Aquatic Organisms, Environmental Pollution GirişTüm organizmalarda olduğu gibi sucul canlılarda da çevresel şartlar nedeniyle oluşan stres etkileri, oksidatif stres ile ilişkilendirilebilir. Sucul canlılarda oksidatif strese neden olduğu bilinen çevresel şartlar genellikle; sıcaklık, oksijen seviyesi, tuzluluk, mevsimsel ritim değişiklikleri, geçiş metal iyonları, pestisitler ve petrol türevleri olarak sınıflandırılabilir. Bu derleme çalışmasında, sucul organizmaların çevresel şartlara karşı geliştirdikleri oksidatif stres ve adaptif yanıtların irdelenmesi amaçlanmıştır. 1.1.Sıcaklık ve Oksijen SeviyesiSıcaklık ve çözünmüş oksijen seviyesi sucul canlıların dağılımında önemli parametrelerdir. Sıcaklık, tüm canlı organizmaları etkiler, ancak ektotermik hayvanlar için daha kritiktir.

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Effects of redox cycling compounds on glutathione content and activity of glutathione-related enzymes in rainbow trout liver

Cited by 116 publications

References 37 publications

Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

Effects of hexachlorobenzene on antioxidant status of liver and brain of common carp (Cyprinus carpio)

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Sucul Organizmalarda Çevresel Şartlara Karşı Geliştirilen Oksidatif Stres Mekanizmaları ve Adaptif Yanıtlar

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