Effects of red wine, tannic acid, or ethanol on glucose tolerance in non—insulin-dependent diabetic patients and on starch digestibility in vitro

Gin, H.; Rigalleau, Vincent; Caubet, Olivier; Masquelier, J; Aubertin, J

doi:10.1016/s0026-0495(99)90135-x

Cited by 70 publications

(62 citation statements)

References 27 publications

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“…The inhibitory potential of the extracts of N. tabacum against the activities of α-amylase and α-glucosidase may be due to the presence of phytochemicals such as tannins, saponins and flavonoids. Studies have shown that tannins possess multiple biological activities including antioxidant, anticancer and antimicrobial activities (Gin et al, 1999;Amarowicz., 2007). Tannins have also been reported to have health benefits in Alzheimer and diabetes (Ono et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

In vitro</l> study on the hypoglycemic potential of Nicotiana tabacum leaf extracts

Kazeem

Ogungbe

Saibu

et al. 2014

Bangladesh J Pharmacol

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Section: Discussionmentioning

confidence: 99%

In vitro</l> study on the hypoglycemic potential of Nicotiana tabacum leaf extracts

Kazeem

Ogungbe

Saibu

et al. 2014

Bangladesh J Pharmacol

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“…Oxidative stress and free-radical generation were implicated in the genesis and progression of diabetic nephropathy (42). The insulinsensitizing effect of iron depletion is known (39,43,44), and glycemia and insulinemia can be further lowered by both CHO restriction (45,46) and polyphenol intake (47,48). Because iron, hyperinsulinemia, and hyperglycemia act in concert to upregulate free-radical reactions (rev.…”

Section: Discussionmentioning

confidence: 99%

A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy

Facchini

Saylor

2003

Diabetes

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Diabetic nephropathy has become the leading cause of uremia. Several lines of evidence suggest dietary factors other than protein intake have a substantial role in the progression of diabetic nephropathy to end-stage renal disease. The present investigation was initiated to evaluate whether a carbohydrate-restricted, low-ironavailable, polyphenol-enriched (CR-LIPE) diet may delay and improve the outcome of diabetic nephropathy to a greater extent than standard protein restriction. To this aim, 191 diabetic patients, all with type 2 diabetes, were randomized to either CR-LIPE or standard protein restriction and the following outcomes monitored: doubling of serum creatinine, cumulative incidence of endstage renal disease, and all cause mortality. Over a mean follow-up interval of 3.9 ؎ 1.8 years, serum creatinine concentration doubled in 19 patients on CR-LIPE (21%) and in 31 control subjects (39%) (P < 0.01). Renal replacement therapy or death occurred in 18 patients on CR-LIPE (20%) and in 31 control subjects (39%) (P < 0.01). These differences were independent from followup interval, sex, mean arterial blood pressure, HbA 1c , initial renal dysfunction, and angiotensin system inhibitor use. In conclusion, CR-LIPE was 40 -50% more effective than standard protein restriction in improving renal and overall survival rates.

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“…Tannins could cause several effects on the biological system because they are potential metal ion chelators and protein precipitation agents forming insoluble complexes with proteins, as well as biological oxidants (52). Tannic acid and tannin-rich nonalcoholic components of red wine have been shown to reduce serum glucose levels after starch-rich meals in a study of patients with non-insulin dependent diabetes mellitus (53). As the mechanism involved in this anti-hyperglycemic effect is unknown, it is possible that tannins can inhibit α-amylase activity in situ.…”

Section: Phytoconstituents With -Amylase Inhibitory Activitymentioning

confidence: 99%

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

et al. 2012

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-Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases. Plants are an important source of chemical constituents with potential for inhibition of α-amylase and can be used as therapeutic or functional food sources. A review about crude extracts and isolated compounds from plant source that have been tested for α-amylase inhibitory activity has been done. The analysis of the results shows a variety of crude extracts that present α-amylase inhibitory activity and some of them had relevant activity when compared with controls used in the studies. Amongst the phyto-constituents that have been investigated, flavonoids are one of them that demonstrated the highest inhibitory activities with the potential of inhibition related to number of hydroxyl groups in the molecule of the compound. Several phyto-constituents and plant species as α-amylase inhibitors are being reported in this article. Majority of studies have focused on the anti-amylase phenolic compounds.

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Effects of red wine, tannic acid, or ethanol on glucose tolerance in non—insulin-dependent diabetic patients and on starch digestibility in vitro

Cited by 70 publications

References 27 publications

<i>In vitro</l> study on the hypoglycemic potential of <i>Nicotiana tabacum</i> leaf extracts

<i>In vitro</l> study on the hypoglycemic potential of <i>Nicotiana tabacum</i> leaf extracts

A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

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