Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk

Buscemi, Silvio; Rosafio, Giuseppe; Arcoleo, Gioacchina; Mattina, Alessandro; Canino, Baldassare; Montana, M.; Verga, S; Rini, Giovanbattista

doi:10.3945/ajcn.111.031088

Cited by 130 publications

(110 citation statements)

References 52 publications

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“…Literature implies the beneficial effect of a diet rich in polyphenols such as an improvement in the endothelial function, particularly in persons with the RHI below norm. Patients with advanced cardiovascular diseases who consumed red orange juice in the amount of 500 ml per day (2 × 250 ml) for one week were observed to present a significant improvement in the endothelial function defined by the FMD (flow-mediated dilation) parameter measured on the brachial artery by an ultrasound Sonoline G50 device (Siemens, Malvern, USA) (Buscemi et al 2012). In another study, participants with early atherosclerosis consumed olive oil and olive oil supplemented with catechins (EGCG -epigallocatechin-3-gallate) in an amount of 30 ml per day for 4 months and were observed to achieve a significant improvement in the RHI value from 1.38 ± 0.15 to 1.60 ± 0.30.…”

Section: Resultsmentioning

confidence: 99%

Effect of chokeberry juice consumption on antioxidant capacity, lipids profile and endothelial function in healthy people: a pilot study

Nowak¹,

Grąbczewska²,

Gośliński³

et al. 2016

Czech J. Food Sci.

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Nowak D., Grąbczewska Z., Gośliński M., Obońska K., Dąbrowska A., Kubica J. (2016): Effect of chokeberry juice consumption on antioxidant capacity, lipids profile and endothelial function in healthy people: a pilot study. Czech J. Food Sci., 34: 39-46.Many studies show that the consumption of juices rich in polyphenols may increase serum antioxidant capacity, improve blood lipid profile, and endothelial function. The relation between the consumption of chokeberry juice and changes in the antioxidant capacity, blood lipid profile, and endothelial function as important indicators in the assessment of cardiovascular risk were determined. The study was conducted on a group of 11 healthy volunteers, who consumed chokeberry juice for three weeks. The research included determination of serum antioxidant capacity, blood lipid profile analysis, and measurements of endothelial function. The 3-week consumption of chokeberry juice significantly increased serum antioxidant capacity, and the best results were observed just after one week of the experiment. However, there was no significant change in the blood lipid profile, except for the persons with a higher level of triglycerides, in whom the consumption of chokeberry juice reduced these compounds to normal values. The endothelial function was normal in all patients and did not significantly change during the study.

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Section: Resultsmentioning

confidence: 99%

Effect of chokeberry juice consumption on antioxidant capacity, lipids profile and endothelial function in healthy people: a pilot study

Nowak¹,

Grąbczewska²,

Gośliński³

et al. 2016

Czech J. Food Sci.

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“…High urinary potassium excretion is generally recognized as correlating with consuming high amounts of potassium-rich food items, such as fresh vegetables and fruits. These foods are known to have antioxidant and anti-inflammatory effects (25)(26)(27). In addition, a high potassium intake is reported to increase endotheliumdependent nitric oxide production and decrease saltinduced TGF-b production (28).…”

Section: Primarymentioning

confidence: 99%

Urinary Potassium Excretion and Renal and Cardiovascular Complications in Patients with Type 2 Diabetes and Normal Renal Function

Araki¹,

Haneda

Koya

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives We investigated the association of urinary potassium and sodium excretion with the incidence of renal failure and cardiovascular disease in patients with type 2 diabetes.Design, setting, participants, & measurements A total of 623 Japanese type 2 diabetic patients with eGFR$60 ml/min per 1.73 m 2 were enrolled in this observational follow-up study between 1996 and 2003 and followed-up until 2013. At baseline, a 24-hour urine sample was collected to estimate urinary potassium and sodium excretion. The primary end point was renal and cardiovascular events (RRT, myocardial infarction, angina pectoris, stroke, and peripheral vascular disease). The secondary renal end points were the incidence of a 50% decline in eGFR, progression to CKD stage 4 (eGFR,30 ml/min per 1.73 m 2 ), and the annual decline rate in eGFR.Results During the 11-year median follow-up period, 134 primary end points occurred. Higher urinary potassium excretion was associated with lower risk of the primary end point, whereas urinary sodium excretion was not. The adjusted hazard ratios for the primary end point in Cox proportional hazards analysis were 0.56 (95% confidence interval [95% CI], 0.33 to 0.95) in the third quartile of urinary potassium excretion (2.33-2.90 g/d) and 0.33 (95% CI, 0.18 to 0.62) in the fourth quartile (.2.90 g/d) compared with the lowest quartile (,1.72 g/d). Similar associations were observed for the secondary renal end points. The annual decline rate in eGFR in the fourth quartile of urinary potassium excretion (-1.3 ml/min per 1.73 m 2 /y; 95% CI, -1.5 to -1.0) was significantly slower than those in the first quartile (-2.2; 95% CI, -2.4 to -1.8).Conclusions Higher urinary potassium excretion was associated with the slower decline of renal function and the lower incidence of cardiovascular complications in type 2 diabetic patients with normal renal function. Interventional trials are necessary to determine whether increasing dietary potassium is beneficial.

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“…Between the fruits highly consumed, citrus and apples have been proven to have beneficial effects against a number of diseases, such as cardiovascular disease, diabetes and some cancers as well as some age-related disorders (Buscemi et al, 2012;Jedrychowski et al, 2010). These protective effects can be related to the actions of specific compounds such as vitamin C and polyphenols on inflammation and oxidative stress (Bouayed et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Codoñer‐Franch

Betoret

López-Jaén

et al. 2013

International Journal of Food Sciences and Nutrition

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Codoñer Franch, P.; Betoret Valls, ME.; López Jaén, AB.; Betoret Valls, N.; Fito Maupoey, P.; Valls Bellés, MV. (2013). Dried apple enriched with mandarin juice counteracts tamoxifen induced oxidative stress in rats. International Journal of Food Sciences and Nutrition. 64(7): 815-821. doi:10.3109/09637486.2013.798267. Dried apple enriched with mandarin juice by vacuum impregnation counteracts the liver oxidative effect of tamoxifen in rats. AbstractWe have investigated the effects of a product made of apple dehydrated enriched by vacuum impregnation of mandarin juice in decreasing oxidative stress biomarkers in rat induced liver injury by tamoxifen. A experimental design was undertaken in six groups of animals. One group fed a standard diet. Two groups were supplemented with 0.745 g/d of apples snacks/day either impregnated or not with mandarin juice during 28 days. Three groups of rats were treated with tamoxifen 1.54 mg/kg/day during 21 days; of these, one group was supplemented with the apple snacks and the other with the apple snacks impregnated with mandarin juice. Plasma aminotransferases were determined as index of hepatocellular damage and interleukin-6 as measure of inflammation. Plasma and liver carbonyl groups, indicative of protein oxidation, and α-tocopherol as evaluation of antioxidant defense were measured. The modified base 8-hydroxydexyguanosine as indicative of DNA damage was determined in liver. Tamoxifen induced an increase in aminotranferases and both plasma and liver markers of oxidative stress and DNA damage that decrease significantly after apple snack consumption; in most of cases they even reach normal values as those achieved previous to induce the injury with tamoxifen. The effect of the mandarin juice incorporated to the structure of apple mainly accounts for increasing levels of α-tocopherol in plasma and liver. The present study shown the potential protective action of the products made of dehydrated apple either impregnated or not with mandarin juice by vacuum impregnation for counteracting the chemically induced liver injury in rats.

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Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk

Cited by 130 publications

References 52 publications

Effect of chokeberry juice consumption on antioxidant capacity, lipids profile and endothelial function in healthy people: a pilot study

Effect of chokeberry juice consumption on antioxidant capacity, lipids profile and endothelial function in healthy people: a pilot study

Urinary Potassium Excretion and Renal and Cardiovascular Complications in Patients with Type 2 Diabetes and Normal Renal Function

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

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