Effects of recombinant human growth hormone on rat septic shock with intraabdominal infection by<i>E. coli</i>

Huang, Ying; Wang, Shuren; Yi, Cheng; Ying, Ming-Ying; Lin, Ying Q.; Zhi, Maohui

doi:10.3748/wjg.v8.i6.1134

Cited by 19 publications

(18 citation statements)

References 34 publications

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“…Some studies have indicated that treatment with GH is safe and beneficial for patients with mild sepsis and severe sepsis, as well as for critically ill patients without sepsis. We have previously demonstrated that rhGH can improve the circulatory function and increase the survival of rats in septic shock (5). However, it has been demonstrated that administration of rhGH to long-stay critically ill adults increases morbidity and mortality (18,19).…”

Section: Discussionmentioning

confidence: 99%

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Beneficial effect of recombinant human growth hormone on the intestinal mucosa barrier of septic rats

Cao

Wang

et al. 2007

Braz J Med Biol Res

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The objective of the present study was to investigate the effects of recombinant human growth hormone (rhGH) on the intestinal mucosa barrier of septic rats and explore its possible mechanism. Female Sprague-Dawley rats were randomized into three groups: control, Escherichia coli-induced sepsis (S) and treatment (T) groups. Groups S and T were subdivided into subgroups 1d and 3d, respectively. Expression of liver insulin-like growth factor-1 (IGF-1) mRNA, Bcl-2 and Bax protein levels and the intestinal Bax/Bcl-2 ratio, and plasma GH and IGF-1 levels were determined. Histological examination of the intestine was performed and bacterial translocation was determined. rhGH significantly attenuated intestinal mucosal injuries and bacterial translocation in septic rats, markedly decreased Bax protein levels, inhibited the decrease of Bcl-2 protein expression and maintained the Bax/Bcl-2 ratio in the intestine. rhGH given after sepsis significantly improved levels of plasma GH (T1d: 1.28 ± 0.24; T3d: 2.14 ± 0.48 µg/L vs S1d: 0.74 ± 0.12; S3d: 0.60 ± 0.18 µg/L; P < 0.05) and T3d: 201.56 ± 64.98 µg/L vs S1d: 116.72 ± 13.96; S3d: 107.50 ± 23.53 µg/L; P < 0.05) and expression of liver IGF-1 mRNA (T1d: 0.98 ± 0.20; T3d: 1.76 ± 0.17 vs S1d: 0.38 ± 0.09; S3d: 0.46 ± 0.10; P < 0.05). These findings indicate that treatment with rhGH had beneficial effects on the maintenance of the integrity of the intestinal mucosa barrier in septic rats.

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Section: Discussionmentioning

confidence: 99%

“…Both animal and human studies have demonstrated that recombinant human growth hormone (rhGH) can enhance protein synthesis, promote tissue recovery, stimulate intestinal epithelial growth, etc. (3)(4)(5). However, the mechanism of the protective effect of rhGH on the intestinal mucosa barrier is not understood.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effect of recombinant human growth hormone on the intestinal mucosa barrier of septic rats

Cao

Wang

et al. 2007

Braz J Med Biol Res

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“…Recent studies demonstrated that rhGH might protect the damage of the intestinal mucosa by inhibiting apoptosis of intestinal mucosa cells and increasing of IGF-1 levels (11,15,17,25). The biological effects of GH are indirectly mediated by IGF-1.…”

Section: Discussionmentioning

confidence: 99%

“…The biological effects of GH are indirectly mediated by IGF-1. IGF-1 can prevent intestinal atrophy in septic rats and protect the integrity of intestinal structure (11,12,13,18,21). Gary et al reported that the development of bacterial translocation is inversely correlated with serum IGF-1 levels and treatment with IGF-1 decreased enterocyte apoptosis (19).…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of growth hormone on bacterial translocation and intestinal damage in rats with partial intestinal obstruction

Kaymakci¹,

Güven²,

Çiftçi³

et al. 2014

BLL

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Abstract:Objective: One of the reasons of bacterial translocation (BT) is the complete or partial intestinal obstructions (PIO) of the gastrointestinal system. In this study, we aimed to investigate the effects of recombinant human Growth Hormone (rhGH) on BT in rats with partial intestinal obstruction (PIO). Material and methods:The rats were randomly divided into the 4 groups: Group I: Sham-operated (SO) (n = 12), Group II control PIO (n = 12), Group III: PIO with rhGH treatment for 5 days (n = 12), Group IV: PIO with rhGH treatment 5 days before PIO and 5 days after PIO (a total of 10 days) (n = 12). In the groups III and IV, the effects of 5 and 10 days administered rhGH were examined. Results: The level of serum and of intestinal fl uid IgA was signifi cantly higher in the Group IV compared to the Group I, Group II and Group III. In the Group IV, the number of small intestinal goblet and colonic goblet cells, and the lengths of intestinal mucosal villi and crypt depths were statistically signifi cantly higher than in Groups II and III. The rate of bacterial translocation was higher in the Group II: 100 % in MLNs, 41.6 % in blood culture and 50.8 % in the liver cultures, it was signifi cantly higher compared to the other groups (p < 0.01). Conclusions:The study results demonstrated that administration of rhGH to the rats with PIO for at least 10 days decreased bacterial translocation (Fig. 3, Ref. 25). Text in PDF www.elis.sk.

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Effects of recombinant human growth hormone on acute lung injury in endotoxemic rats

Wang

Zhang

et al. 2006

Inflamm. res.

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Effects of recombinant human growth hormone on rat septic shock with intraabdominal infection byE. coli

Cited by 19 publications

References 34 publications

Beneficial effect of recombinant human growth hormone on the intestinal mucosa barrier of septic rats

Beneficial effect of recombinant human growth hormone on the intestinal mucosa barrier of septic rats

Protective effects of growth hormone on bacterial translocation and intestinal damage in rats with partial intestinal obstruction

Effects of recombinant human growth hormone on acute lung injury in endotoxemic rats

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