Effects of recombinant human growth hormone in the treatment of dwarfism and relationship between IGF-1, IGFBP-3 and thyroid hormone

Ren, Shanxiang; Nie, Yuxiang; Wang, Aihong

doi:10.3892/etm.2016.3831

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…In the present study, the children with ISS had higher IGF-1 and IGFBP-3 levels than the children with GHD, and the difference was statistically significant. This result was concordant with previous studies ( 9 , 10 ). IGF-1 is mainly synthesized and secreted by the liver, and its expression varies under the influence of various factors, including GH.…”

Section: Discussionsupporting

confidence: 94%

Development of a predictive model of growth hormone deficiency and idiopathic short stature in children

Cong

Qiu

et al. 2021

Exp Ther Med

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The aim of the present study was to develop predictive models using clinical features and MRI texture features for distinguishing between growth hormone deficiency (GHD) and idiopathic short stature (ISS) in children with short stature. This retrospective study included 362 children with short stature from Children's Hospital of Hebei Province. GHD and ISS were identified via the GH stimulation test using arginine. Overall, there were 190 children with GHD and 172 with ISS. A total of 57 MRI texture features were extracted from the pituitary gland region of interest using C++ language and Matlab software. In addition, the laboratory examination data were collected. Receiver operating characteristic (ROC) regression curves were generated for the predictive performance of clinical features and MRI texture features. Logistic regression models based on clinical and texture features were established for discriminating children with GHD and ISS. Two clinical features [IGF-1 (insulin growth factor-1) and IGFBP-3 (IGF binding protein-3) levels] were used to build the clinical predictive model, whereas the three best MRI textures were used to establish the MRI texture predictive model. The ROC analysis of the two models revealed predictive performance for distinguishing GHD from ISS. The accuracy of predicting ISS from GHD was 64.5% in ROC analysis [area under the curve (AUC), 0.607; sensitivity, 57.6%; specificity, 72.1%] of the clinical model. The accuracy of predicting ISS from GHD was 80.4% in ROC analysis (AUC, 0.852; sensitivity, 93.6%; specificity, 65.8%) of the MRI texture predictive model. In conclusion, these findings indicated that a texture predictive model using MRI texture features was superior for distinguishing children with GHD from those with ISS compared with the model developed using clinical features.

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Section: Discussionsupporting

confidence: 94%

Development of a predictive model of growth hormone deficiency and idiopathic short stature in children

Cong

Qiu

et al. 2021

Exp Ther Med

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“…To assess the applicability of the cross-linked reaction, DBB reacted with r-hGH (22.1 kDa size), which has previously shown promising clinical activity in patients with dwarfism. 31 R-hGH bearing eight Y and two disulfide bridges was digested to generate 19 fragments. This study has focused on the peptide fragments containing tyrosine residues (i.e., #4, #6, #10, and #14) (Figure 4).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Tyrosine-Reactive Cross-Linker for Probing Protein Three-Dimensional Structures

Wei

et al. 2021

Anal. Chem.

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Cross-linking mass spectrometry (XL-MS) has made significant progress in understanding the structure of protein and elucidating architectures of larger protein complexes. Current XL-MS applications are limited to targeting lysine, glutamic acid, aspartic acid, and cysteine residues. There remains a need for the development of novel cross-linkers enabling selective targeting of other amino acid residues in proteins. Here, a novel simple crosslinker, namely, [4,4′-(disulfanediylbis(ethane-2,1-diyl)) bis(1,2,4triazolidine-3,5-dione)] (DBB), has been designed, synthesized, and characterized. This cross-linker can react selectively with tyrosine residues in protein through the electrochemical click reaction. The DBB cross-links produced the characteristic peptides before and after electrochemical reduction, thus permitting the simplified data analysis and accurate identification for the crosslinked products. This is the first time a cross-linker is developed for targeting tyrosine residues on protein without using photoirradiation or a metal catalyst. This strategy might potentially be used as a complementary tool for XL-MS to probe protein 3D structures, protein complexes, and protein−protein interaction.

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Evaluation of Safety and Efficacy of Growth Hormone Therapy by IGF-1 Z Score in Children with Short Stature

2019

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Effects of recombinant human growth hormone in the treatment of dwarfism and relationship between IGF-1, IGFBP-3 and thyroid hormone

Cited by 3 publications

References 19 publications

Development of a predictive model of growth hormone deficiency and idiopathic short stature in children

Development of a predictive model of growth hormone deficiency and idiopathic short stature in children

Tyrosine-Reactive Cross-Linker for Probing Protein Three-Dimensional Structures

Evaluation of Safety and Efficacy of Growth Hormone Therapy by IGF-1 Z Score in Children with Short Stature

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