Effects of recombinant human granulocyte and granulocyte-macrophage colony-stimulating factors on neutrophil function following autologous bone marrow transplantation

Gadish, M.; Kletter, Yehudith; Flidel, Orna; Nagler, Arnon; Slavin, Shimon; Fabian, Ina

doi:10.1016/0145-2126(91)90187-x

Cited by 34 publications

(30 citation statements)

References 27 publications

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“…This could be demonstrated patients undergoing allogeneic or autologous BMT. 49,113 The in neutrophils from patients with chronic granulomatous disadministration of GM-CSF after BMT could correct the defecease who have a severely impaired ability to produce ROI. 42 tive ROI production in some patients.…”

Section: Impaired Chemotaxis Prior To G-csfmentioning

confidence: 99%

Functional features of neutrophils induced by G-CSF and GM-CSF treatment: differential effects and clinical implications

et al. 1997

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Section: Impaired Chemotaxis Prior To G-csfmentioning

confidence: 99%

Functional features of neutrophils induced by G-CSF and GM-CSF treatment: differential effects and clinical implications

et al. 1997

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“…56 However, despite the routine use of growth factors, neutrophils can remain dysfunctional for up to 2 months post-HCT, and for up to a year in those who develop GVHD. 54,[57][58][59][60] The ability of neutrophils to kill invasive fungi is regained in most patients by about 3 months post-HSCT; however, in patients who develop invasive fungal infection (IFI),neutrophil function make take 6-12 months to recover. 61 Polymorphisms in genes involved in the innate recognition of fungi also appear to play a critical role in determining infection outcomes.…”

Section: Recovery Of Mucosal Injurymentioning

confidence: 99%

“…The use of growth factors not only hastens engraftment of granulocytes and monocytes but also enhances their function to some extent. [52][53][54] As compared with G-CSF, which primarily aids in the proliferation of neutrophils, GM-CSF also increases the number or monocytes and macrophages. 55 A prospective randomized trial reported that the use of GM-CSF or a combination of GM-CSF and G-CSF post-HSCT is associated with a significantly lower incidence of IFI-related mortality (1.5%) compared with G-CSF alone (12%), P D 0.034.…”

Section: Recovery Of Mucosal Injurymentioning

confidence: 99%

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

2016

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Infection is the leading cause of non-relapse mortality after allogeneic haematopoietic cell transplantation (HCT). This occurs as a result of dysfunction to the host immune system from the preparative regimen used prior to HCT, combined with a delay in reconstitution of the donorderived immune system after HCT. In this article, we elaborate on the process of immune reconstitution post-HCT that begins with the innate system and is followed by recovery of adaptive immunity. Simultaneously, we describe how the tempo of immune reconstitution influences the risk of various infections. We explain some of the key differences in immune reconstitution and the consequent risk of infections in recipients of peripheral blood stem cell, bone marrow or umbilical cord blood grafts. Other factors that impact on immune recovery are also highlighted. Finally, we allude to various strategies that are being tested to enhance immune reconstitution post-HCT.

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“…Humphrey et al (1991) and Gadish et al (1991) reported that recovery of leukocyte function was delayed in patients who had received ABMT. Taken together, these results imply that PBSCT is superior to ABMT with respect to the recovery of not only leukocyte count but also leukocyte function.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that patients who receive systemic chemotherapy often sustain impairment of leukocyte function as well as profound leukocytopenia (Ichinose et al, 1986;Yoshida et al, 1993;Okada et al, 1994). In addition, a prolonged impairment of leukocyte function in patients who received SHDT with ABMT has been reported (Humphrey et al, 1991;Gadish et al, 1991). In the present study, we evaluated the recovery of the leukocyte functions as exemplified by superoxide production and phagocytosis in patients undergoing SHDT with PBSCT.…”

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confidence: 99%

Recovery of leukocyte function after super-high-dose chemotherapy with peripheral blood stem cell transplantation in testicular cancer patients

et al. 1997

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Leukocyte functions (superoxide production and phagocytosis) were evaluated in patients with testicular cancer who had undergone super-high-dose chemotherapy (SHDT) with peripheral blood stem cell transplantation (PBSCT). In 5 patients with advanced or relapsed testicular cancer who received 8 cycles of SHDT with PBSCT, we measured superoxide production activity by phorbol myristate acetate (PMA) stimulation, as well as phagocytic activity using latex particles before and after PBSCT. The median time to reach a leukocyte count of > >1,000/ml was 9 days after PBSCT. Superoxide production activity was significantly decreased on day 7 compared with the pre-chemotherapy level. However, it recovered by day 12 and sustained such a level thereafter. Phagocytic activity was within the normal range on day 7 but declined slightly on days 12 and 21 compared with the pre-chemotherapy level. Our results indicate that leukocyte function and leukocyte count recover promptly following PBSCT and that PBSCT is a safe and convenient adjunctive therapy after SHDT for patients with advanced testicular cancer. Int.

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Effects of recombinant human granulocyte and granulocyte-macrophage colony-stimulating factors on neutrophil function following autologous bone marrow transplantation

Cited by 34 publications

References 27 publications

Functional features of neutrophils induced by G-CSF and GM-CSF treatment: differential effects and clinical implications

Functional features of neutrophils induced by G-CSF and GM-CSF treatment: differential effects and clinical implications

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

Recovery of leukocyte function after super-high-dose chemotherapy with peripheral blood stem cell transplantation in testicular cancer patients

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