Effects of rapid maxillary expansion and mandibular advancement on upper airways in Marfan’s syndrome children: a home sleep study and cephalometric evaluation

Taddei, Marco; Alkhamis, Nadia; Tagariello, Teresa; D’Alessandro, Giovanni; Mariucci, Elisabetta; Piana, Gabriela

doi:10.1007/s11325-015-1141-y

Cited by 23 publications

(31 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 in the online version of this article). After review of the downloaded studies, eight had duplicate and/or cumulative data, whereas 17 studies met criteria and had unique data.…”

Section: Resultsmentioning

confidence: 99%

Rapid maxillary expansion for pediatric obstructive sleep apnea: A systematic review and meta‐analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…1 in the online version of this article). After review of the downloaded studies, eight had duplicate and/or cumulative data, whereas 17 studies met criteria and had unique data.…”

Section: Resultsmentioning

confidence: 99%

Rapid maxillary expansion for pediatric obstructive sleep apnea: A systematic review and meta‐analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…At T2 the values were not significant (p value: 0.442 for both AHI and ODI). Horizontal airway dimensions were significantly reduced and vertical airway values were significantly increased in Marfan's syndrome at T0 and T1 but not at T2 (p values at T2: 0.071 for Phw1-Psp, 0.106 for Phw1-Psp', 0.101 for Phw2-Tb, 0.559 for UAL male and 0.560 for UAL female) [67] . The rapid maxillary expansion and the mandibular advancement significantly improved the airway patency of Marfan's syndrome children.…”

Section: The Early Orthodontic Treatment As Prevention Of Osamentioning

confidence: 92%

“…From this overview followed the research of an early orthodontic treatment for MFS children with the aim of reducing the risk factors, such as skeletal class II malocclusion with mandibular retrognathia and reduced sizes of the airways, for OSA development in this particular population [67] . Skeletal Class II malocclusions caused by mandibular retrognathia and correlated increased overjet (defined as the anterior-posterior distance between the upper and lower incisors during normal occlusion), frequently found in Marfan's syndrome [6] , were in fact reported in the literature to be one of the risk factors for OSA development in all patients [68] .…”

Section: The Early Orthodontic Treatment As Prevention Of Osamentioning

confidence: 99%

The prevalence of obstructive sleep apnea and its association with cardiovascular diseases in Marfan’s syndrome children: the state of the art and the early orthodontic treatment

Taddei

2015

Musculoskelet Regen

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) is a sleep disorder that involves a cessation or a significant decrease in airflow in the presence of breathing effort. It is the most common type of sleep-disordered breathing and it is characterized by recurrent episodes of upper airway collapse during sleep. Several studies have documented a higher prevalence of OSA among patients with Marfan's syndrome (MFS), which has been associated with abnormalities in maxillary morphology and craniofacial structures, and abnormally high collapsibility of the connective tissue. There is an association between OSA and vascular disease. From the complex physiological changes that actually occur during OSA and the results obtained from animal models and laboratory-based studies in recent years, plausible hypotheses have been given to link OSA with vascular disease. Intermittent hypoxia, the intermittent arousal from sleep and increased intrathoracic pressure swings are these plausible hypotheses, however, the only mechanism supported by randomized controlled trials (RCTs) able to explain the associations observed between OSA and vascular disease is the increased sympathetic nervous system activity. The aortic dilation, the associated aortic dissection, and the subsequent rupture are still the main cause of morbidity and mortality in MFS patients. The identification of any treatable risk factor for aortic complications in MFS subjects is thus of major scientific and clinical interest. There is some preliminary evidence that OSA may be a risk factor for the development and progression of aortic aneurysms in patients with and without Marfan's syndrome. In literature, it was recently reported that the severity of OSA in MFS subjects is associated with an increased aortic root diameter and that MFS patients with OSA, have a significantly shorter aortic event-free survival than MFS patients without OSA. Furthermore, the skeletal class II malocclusion with mandibular retrognathia and correlated increased overjet has long been recognized to be not only the most typical malocclusion of MFS children but also a significant risk factor for OSA development in all patients. From this overview followed the research of an early orthodontic treatment aimed at the reduction of risk factors for the development of OSA in this particular population. The rapid maxillary expansion and mandibular advancement significantly improved the airway patency and reduced the frequency of apneas in MFS children.

show abstract

“…In Marfan patients, it can often evolve into diplopia. Numerous studies deal with the occlusal appearance and conformation of the oral cavity of patients with Marfan Syndrome (14)(15)(16)(17)(18). Khonsari et al and De Coster studies have shown in Marfan Syndrome patients the tendency to the presence of the ogival palate which is one of the most commonly encountered in such studies.…”

Section: Methodsmentioning

confidence: 99%

“…Frequent feedback is also the presence of significant dental folls and numerous misalignments (16,(19)(20)(21). A single study deals with the presence of obstructive sleep apnea which is quite common in these patients as a result of skeletal alterations (14). De Coster and Shakya and Gorlin treat hypermobility of temporomandibular joint which, with the passage of time, may be responsible for dysfunction of temporomandibular joint including subluxation, frontal dislocation of the articular disk, osteoarthritis.…”

Section: Methodsmentioning

confidence: 99%

Marfan Syndrome: Oral Implication and Management

Bollero

Arcuri

Miranda

et al. 2017

ORL

View full text Add to dashboard Cite

Marfan's Syndrome is a multisistemic pathology of connective tissues, a dominant autosomal transmission, first discovered by a French pediatrician, Antoine Bernard-Jean Marfan, who first found in some of his patients a disproportionate alteration of inferior infertility. This alteration was caused by the mutation of the FBN1 gene, located on the long arm of the chromosome 15, which encodes for an extracellular matrix protein, fibrin-1. Later it was discovered that the disease could occasionally be due also to the mutation of the TGFBR2 gene, which encodes for a TGF-beta receptor 1. The estimated incidence of the disease is 2-3 subjects affected every 10,000, in the absence of predilection ratial, ethnic, geographic and gender. It is believed that some 15,000 people in Italy suffer from Marfan Syndrome. The disease is characterized by a wide range of clinical manifestations that affect different organs. The study evaluates through a literature review the manifestations in the oral cavity of the marfan syndrome and the correct management of the patient during dental maneuvers.

show abstract

Effects of rapid maxillary expansion and mandibular advancement on upper airways in Marfan’s syndrome children: a home sleep study and cephalometric evaluation

Cited by 23 publications

References 31 publications

Rapid maxillary expansion for pediatric obstructive sleep apnea: A systematic review and meta‐analysis

Rapid maxillary expansion for pediatric obstructive sleep apnea: A systematic review and meta‐analysis

The prevalence of obstructive sleep apnea and its association with cardiovascular diseases in Marfan’s syndrome children: the state of the art and the early orthodontic treatment

Marfan Syndrome: Oral Implication and Management

Contact Info

Product

Resources

About