Effects of ramipril on renal function during progressive overpacing-induced heart failure in dogs

Maisonneuve, Mathieu; Motte, Sophie; Ray, Lynn; Pensis, Anne; Jespers, Pascale; Brimioulle, Serge; Laroute, Valérie; Naeije, Robert; Entee, Kathleen Mc

doi:10.2460/ajvr.67.7.1236

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Glomerular filtration rate was measured by plasma clearance of exogenous creatinine (Cl creat ), exo- and endo-iohexol (Cl exo and Cl endo ), adapted from a protocol previously proposed in cats [31]. Combined IV administration of iohexol and creatinine has already been performed in dogs for renal and plasma clearance procedures [32]. Briefly, a 15 mL baseline blood sample was collected from the jugular vein (22 G needle) for basal creatinine concentration.…”

Section: Methodsmentioning

confidence: 99%

Renal Function and Morphology in Aged Beagle Dogs Before and after Hydrocortisone Administration

et al. 2012

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Objectives of this study were to evaluate glomerular filtration rate (GFR), renal structural changes and proteinuria in aged Beagle dogs before and after hydrocortisone (HC) administration. Eleven Beagle dogs ≥10 years old were treated with either hydrocortisone (HC group, n = 6) or placebo (control group, n = 5). Urinary markers, GFR and kidney biopsies were evaluated before (T0), during (T16 wks) and after discontinuing HC administration (T24 wks). Results indicate that HC administration causes a significant increase in GFR. At all time points except T16 wks, proteinuria was higher in the control group than in the HC group, and there was no significant difference in urinary markers between groups. At T16 wks, proteinuria, urinary albumin-to-creatinine (c) ratio, immunoglobulin G/c and retinol-binding protein/c were higher compared to baseline in the HC group. At T0, rare to mild renal lesions were detected in all HC dogs and rare to moderate changes in all control dogs. Glomerulosclerosis progressed in both groups until T24 wks. Tubular atrophy was detected in three HC dogs at T16 wks and T24 wks, but also in five control dogs throughout the study. At every time point, five HC dogs and all control dogs had rare to moderate interstitial inflammation. Rare to mild interstitial fibrosis was found in up to three HC dogs at T16 wks and T24 wks, and severe fibrosis in one HC dog at T24 wks. Up to four control dogs had rare to mild fibrosis at all time points. These findings indicate that clinically healthy, aged Beagle dogs may have considerable renal lesions and proteinuria, which could have implications for experimental or toxicological studies. Additional research is needed to elucidate glucocorticoid effects on renal structure, but functional changes such as hyperfiltration and proteinuria warrant attention to kidney function of canine patients with Cushing's syndrome or receiving exogenous glucocorticoids.

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Section: Methodsmentioning

confidence: 99%

Renal Function and Morphology in Aged Beagle Dogs Before and after Hydrocortisone Administration

et al. 2012

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“…The PECC and PIoxC have been used in dogs with various clinical conditions or clinical situations. For example, PECC has been used in the evaluation of naturally occurring renal and nonrenal diseases, 8 CKD secondary to leishmaniasis, 9 chronic valvular disease, 10 renal safety of cardiac drugs, 11 and hypothyroidism 12,13 ; PIoxC has been used in the evaluation of pyometra, 14 experimentally induced heart failure, 15 and cholecalciferol-induced toxicosis. 16 Distinct advantages exist for PECC and PIoxC.…”

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confidence: 99%

Comparison of pharmacokinetic variables for creatinine and iohexol in dogs with various degrees of renal function

Collignon¹,

Heiene²,

Quéau³

et al. 2012

ajvr

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Effects of Mitral Regurgitation on the Reflex Diuresis to Pulmonary Lymphatic Obstruction in Rabbits

Hallam

Edirisinghe

Balasuriya

et al. 2007

Experimental Lung Research

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Increasing the extravascular fluid of the airways acutely by obstructing pulmonary lymph drainage causes a reflex diuresis mediated by neuronal nitric oxide synthase in the renal medulla. The authors examined this reflex in rabbits with a chronic increase in extravascular fluid of the airways resulting from surgically induced mitral regurgitation. Intact rabbits served as controls. Renal neuronal (nNOS) and endothelial (eNOS) nitric oxide synthase expressions were also examined. The reflex was absent in rabbits with mitral regurgitation. There were significant increases in medullary and cortical nNOS mRNA compared to controls. The observed changes in mRNA levels correlated with nNOS protein levels. eNOS mRNA was unaffected.

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Effects of ramipril on renal function during progressive overpacing-induced heart failure in dogs

Abstract: Results suggest that, in this rapid-evolving, dilated cardiomyopathy, activation of the renin-angiotensin system contributes to the pathophysiology of heart failure late in the disease and essentially by an activation of renal salt and water retention.

Cited by 3 publications

References 31 publications

Renal Function and Morphology in Aged Beagle Dogs Before and after Hydrocortisone Administration

Renal Function and Morphology in Aged Beagle Dogs Before and after Hydrocortisone Administration

Comparison of pharmacokinetic variables for creatinine and iohexol in dogs with various degrees of renal function

Effects of Mitral Regurgitation on the Reflex Diuresis to Pulmonary Lymphatic Obstruction in Rabbits

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