Effects of Ramadan Fasting on Glycaemic Control Among Patients with Type 2 Diabetes: Systematic Review and Meta-analysis of Observational Studies

Elmajnoun, Hala K.; Faris, MoezAlIslam E.; Abdelrahim, Dana N.; Haris, Parvez I.; Abu-Median, Abu-Bakr

doi:10.1007/s13300-022-01363-4

Cited by 6 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Usually they eat two meals a day, one before the sunrise and the other shortly after sunset. Systematic reviews and meta-analyses have shown that Ramadan fasting promoted minimal improvements in fasting glucose in healthy subjects [ 6 ], although greater effects were found in subjects with type 2 diabetes [ 48 , 49 ]. There is a significant but small body weight loss after Ramadan practice [ 50 ], though this lost weight is rapidly regained [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis

Rovira-Llopis,

Luna-Marco,

Perea-Galera

et al. 2023

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Daily rhythms of metabolic function are supported by molecular circadian clock systems that are strongly regulated by feeding and fasting. Intermittent fasting diets have been associated with weight loss and improved metabolism. However, the effects of time-restricted eating (TRE) on glycemic parameters are still under debate. In this review, we aim to systematically analyze the effects of TRE on glycemic parameters. We searched on PubMed, EMBASE, and the Cochrane Library for controlled studies in which subjects followed TRE for at least 4 weeks. 20 studies were included in the qualitative systematic review, and 18 studies (n = 1169 subjects) were included in the meta-analysis. Overall, TRE had no significant effect on fasting glucose (Hedges’s g = -0.08; 95% CI:-0.31,0.16; p = 0.52), but it did reduce HbA1c levels (Hedges’s g = -0.27; 95% CI: -0.47, -0.06; p = 0.01). TRE significantly reduced fasting insulin (Hedges’s g = -0.40; 95% CI: -0.73,-0.08; p = 0.01) and showed a tendency to decrease HOMA-IR (Hedges’s g = -0.32; 95% CI:-0.66,0.02; p = 0.06). Interestingly, a cumulative analysis showed that the beneficial effects of TRE regarding glucose levels were less apparent as studies with later TRE windows (lTRE) were being included. Indeed, a subgroup analysis of the early TRE (eTRE) studies revealed that fasting glucose was significantly reduced by eTRE (Hedges’s g = -0.38; 95% CI:-0.62, -0.14; p < 0.01). Our meta-analysis suggests that TRE can reduce HbA1c and insulin levels, and that timing of food intake is a crucial factor in the metabolic benefit of TRE, as only eTRE is capable of reducing fasting glucose levels in subjects with overweight or obesity.PROSPERO registration number CRD42023405946.

show abstract

Section: Discussionmentioning

confidence: 99%

Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis

Rovira-Llopis,

Luna-Marco,

Perea-Galera

et al. 2023

Rev Endocr Metab Disord

View full text Add to dashboard Cite

show abstract

“…Furthermore, Elmajnoun et al 13 performed a systematic review and meta-analysis to investigate the impact of RF on glycemic control in patients with T2D in relevant studies (January 2000–December 2021). Observational studies that examined the changes in BW and glucose parameters (HbA1c and FBG) before and after RF among different age groups with T2D were included in the systemic review and meta-analysis.…”

Section: Highlights Of the Literaturementioning

confidence: 99%

Diabetes and Ramadan Fasting (2023): The Year in Review

Abusahmin,

Abdelgadir,

Eledrisi

et al. 2024

Journal of Diabetes and Endocrine Practice

View full text Add to dashboard Cite

Introduction We aimed to provide an overview of the global literature production on diabetes and Ramadan in the past year (2023). Materials and Methods This is a narrative, nonsystematic review of the international literature from two major medical online databases (PubMed and Google Scholar) in 2023. The search term “Diabetes AND Ramadan fasting” was used, and the relevant literature was narrated in a concise thematic account. Results The publications spanned a vast array of topics related to diabetes and Ramadan fasting (RF), including physiology and nutrition, risk assessment stratification tools and their validation, assessments of safety and efficacy profiles of older and newer diabetes therapies, diabetes education, use of advanced technology for the treatment, and monitoring and impact on pregnancy. Some reports covered the interaction between Ramadan and COVID-19 concerning diabetes, pregnancy, complications, and unique characteristics of diabetes and fasting by young and older people. Conclusion The current narration presents this year's global scholarly production on the safety of fasting practices, care models, and patients' experiences and perspectives.

show abstract

“…As a result, it has been observed that people observing a period of pre-Ramadan assessment with clinicians, as a personalized approach, could improve metabolic balance and also prevent acute complications during and after Ramadan period. 99,100 Nutrigenetics studies the role of genetic variants in the modulation of response to diet and the implications in the development, or prevention, of diseases. In particular, some genetic variants seem associated with diet response for what concerns the development of cardiovascular diseases, mainly obesity and diabetes.…”

Section: Dietmentioning

confidence: 99%

Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations

Galiero,

Caturano,

Vetrano

et al. 2023

DMSO

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases in Western countries, and its incidence is constantly increasing. Epidemiological studies have shown that in the next 20 years. The number of subjects affected by T2DM will double. In recent years, owing to the development and improvement in methods for studying the genome, several authors have evaluated the association between monogenic or polygenic genetic alterations and the development of metabolic diseases and complications. In addition, sedentary lifestyle and socio-economic and pandemic factors have a great impact on the habits of the population and have significantly contributed to the increase in the incidence of metabolic disorders, obesity, T2DM, metabolic syndrome, and liver steatosis. Moreover, patients with type 2 diabetes appear to respond to antihyperglycemic drugs. Only a minority of patients could be considered true non-responders. Thus, it appears clear that the main aim of precision medicine in T2DM is to identify patients who can benefit most from a specific drug class more than from the others. Precision medicine is a discipline that evaluates the applicability of genetic, lifestyle, and environmental factors to disease development. In particular, it evaluated whether these factors could affect the development of diseases and their complications, response to diet, lifestyle, and use of drugs. Thus, the objective is to find prevention models aimed at reducing the incidence of pathology and mortality and therapeutic personalized approaches, to obtain a greater probability of response and efficacy. This review aims to evaluate the applicability of precision medicine for T2DM, a healthcare burden in many countries.

show abstract

Effects of Ramadan Fasting on Glycaemic Control Among Patients with Type 2 Diabetes: Systematic Review and Meta-analysis of Observational Studies

Cited by 6 publications

References 44 publications

Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis

Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis

Diabetes and Ramadan Fasting (2023): The Year in Review

Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations

Contact Info

Product

Resources

About