Effects of radiofrequency exposure on in vitro blood-brain barrier permeability in the presence of magnetic nanoparticles

Senturk, Fatih; Çakmak, Soner; Kocum, Ismail Cengiz; Gümüşderelı́oğlu, Menemşe; Öztürk, Güler

doi:10.1016/j.bbrc.2022.01.112

Cited by 7 publications

(7 citation statements)

References 31 publications

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“…Electromagnetic effects transiently increasing blood–brain and blood–tumor barrier permeability include magnetic heating of magnetic NPs with a low (magnetic field amplitude 7.6 kA/m at 150 kHz [ 187 ] and 33.4 kA/m at 300 kHz [ 188 ]) or high (source frequency 13.56 MHz at the power of 80 W [ 189 ], source frequency 915 MHz at the power of 5 mW [ 190 ] or 20 mW [ 191 ]) radiofrequency source, laser heating (green picosecond 532 nm laser with the doses of 2.5–25 mJ/cm 2 [ 192 ], near-infrared (NIR) 980 nm laser with the power densities of 0.15–0.72 W/cm 2 [ 193 ], near-infrared 808 nm laser with the doses of 10 and 30 J/cm 2 [ 194 ] and femtosecond NIR laser with the power of 300–2000 mW [ 195 ]), ionizing radiation produced by the cone beam clinical source with the accelerating voltage of up to 6 MV at the doses of 2–10 Gy and laser/X-ray combined impact with the use of an NIR 808 nm laser at the power densities of 1–3 W/cm 2 and a clinical X-ray source with the dose of 6 Gy [ 196 ]. If there is a favorable prognosis, the use of methods of this group seems undesirable due to possible delayed negative effects (for example, secondary tumors induced by radiation), as well as insufficient knowledge of the effects of low-intensity radiofrequency fields on viable tissues.…”

Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

et al. 2023

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Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials. However, the practical application of nanoparticle-based medicine in living organisms is limited by physiological barriers (blood–tissue barriers), which significantly hampers the transport of nanoparticles from the blood into the tumor tissue. This review focuses on several approaches that facilitate the translocation of nanoparticles across blood–tissue barriers (BTBs) to efficiently accumulate in the tumor. To overcome the challenge of BTBs, several methods have been proposed, including the functionalization of particle surfaces with cell-penetrating peptides (e.g., TAT, SynB1, penetratin, R8, RGD, angiopep-2), which increases the passing of particles across tissue barriers. Another promising strategy could be based either on the application of various chemical agents (e.g., efflux pump inhibitors, disruptors of tight junctions, etc.) or physical methods (e.g., magnetic field, electroporation, photoacoustic cavitation, etc.), which have been shown to further increase the permeability of barriers.

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Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

et al. 2023

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“…Monodisperse iron oxide nanoparticles (IONs) were fabricated by a thermal decomposition method (18), as also reported in our previous studies (8)(9)(10) . Briefly, the thermal decomposition process involves two steps.…”

Section: Fabrication Of Monodisperse Iron Oxide Nanoparticles (Ions)mentioning

confidence: 96%

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

Senturk

2023

Hittite Journal of Science and Engineering

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Magnetic nano hyperthermia (MNH) is a promising technique for the treatment of a variety of malignancies. This non-invasive technique employs magnetic nanoparticles and alternating magnetic fields to generate local heat at the tumor location, which activates cell death pathways. However, the efficacy of MNH is dependent on the physicochemical properties of the magnetic nanoparticles, such as size, size distribution, magnetic properties, biocompatibility, and dispersibility in the medium. In this study, it is aimed to evaluate the heating capacity of poly (lactic-co-glycolic acid)-poly (ethylene glycol) di-block copolymer (PLGA-b-PEG) coated monodisperse iron oxide nanoparticles (IONs) as an effective mediator for MNH application. For this purpose, monodisperse IONs with a narrow size distribution and a mean particle size of 8.6 nm have been synthesized via the thermal decomposition method. The resulting IONs were then coated with the PEGylated-PLGA polymer and homogeneously dispersed in the polymeric matrix, which had a clearly defined spherical shape. Additionally, the specific absorption rate (SAR), reflecting the amount of heat dissipation from the NPs to the surrounding medium, was calculated for different concentrations (10, 5, 2.5, and 1.25 mg/mL) of PEGylated-PLGA-IONs. At 5 mg/mL PEGylated-PLGA-IONs (125 μgFe/mL) were found to have a maximum SAR value of 313 W/g. In conclusion, the homogenous dispersion of IONs in PEGylated-PLGA matrix may be one of the critical parameters to enhance the SAR value for MNH-based cancer therapy.

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“…[55] Additionally, several types of research have confirmed that the BBB could be opened by an electromagnetic pulse locally, transiently, and reversibly. [56] In an in vitro BBB model, Fatih Senturk et al [57] investigated if RF could enhance BBB permeability alone or in the presence of magnetic nanoparticles. The results showed the interaction of the RF field alone, and the in vitro BBB model increased FITCdextran after RF.…”

Section: Extra Stimuli-mediated Transport (Esmt)mentioning

confidence: 99%

“…[ 56 ] In an in vitro BBB model, Fatih Senturk et al. [ 57 ] investigated if RF could enhance BBB permeability alone or in the presence of magnetic nanoparticles. The results showed the interaction of the RF field alone, and the in vitro BBB model increased FITC‐dextran after RF.…”

Section: Pathways To Access the Brainmentioning

confidence: 99%

Nanoparticles Mediated the Diagnosis and Therapy of Glioblastoma: Bypass or Cross the Blood–Brain Barrier

Song

Qian

2023

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Glioblastoma is one of the most aggressive central nervous system malignancies with high morbidity and mortality. Current clinical approaches, including surgical resection, radiotherapy, and chemotherapy, are limited by the difficulty of targeting brain lesions accurately, leading to disease recurrence and fatal outcomes. The lack of effective treatments has prompted researchers to continuously explore novel therapeutic strategies. In recent years, nanomedicine has made remarkable progress and expanded its application in brain drug delivery, providing a new treatment for brain tumors. Against this background, this article reviews the application and progress of nanomedicine delivery systems in brain tumors. In this paper, the mechanism of nanomaterials crossing the blood‐brain barrier is summarized. Furthermore, the specific application of nanotechnology in glioblastoma is discussed in depth.

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Effects of radiofrequency exposure on in vitro blood-brain barrier permeability in the presence of magnetic nanoparticles

Cited by 7 publications

References 31 publications

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

Hyperthermia Efficacy of PEGylated-PLGA Coated Monodisperse Iron Oxide Nanoparticles

Nanoparticles Mediated the Diagnosis and Therapy of Glioblastoma: Bypass or Cross the Blood–Brain Barrier

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