Effects of radiation on normal tissue: consequences and mechanisms

Stone, Helen B.; Coleman, C. Norman; Anscher, Mitchell S.; McBride, William H.

doi:10.1016/s1470-2045(03)01191-4

Cited by 743 publications

(597 citation statements)

References 78 publications

Supporting

Mentioning

563

Contrasting

Unclassified

Order By: Relevance

“…For example, in the lung, a small amount of fibrosis is well endured and is commonly present after radiotherapy. However, in the central nervous system, the consequences can be severe (Stone et al, 2003). As the type of tissues exposed to radiation could affect the severity of radiotherapy side effects, we also conducted subgroup analysis of tumor type.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of Associations between ATM Asp1853Asn and TP53 Arg72Pro Polymorphisms and Adverse Effects of Cancer Radiotherapy

Su¹,

Yin²,

Wu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The ataxia telangiectasia mutated (ATM) protein and p53 play key roles in sensing and repairing radiation-induced DNA double strand breaks (DSBs). Accumulating epidemiological evidence indicates that functional genetic variants in ATM and TP53 genes may have an impact on the risk of radiotherapy-induced side effects. Here we performed a meta-analysis to investigate the potential interaction between ATM Asp1853Asn and TP53 polymorphisms and risk of radiotherapy-induced adverse effects quantitatively. Materials and Methods: Relevant articles were retrieved from PubMed, ISI Web of Science and the China National Knowledge Infrastructure (CNKI) databases. Eligible studies were selected according to specific inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to estimate the association between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and risk of radiotherapy adverse effects. All analyses were performed using the Stata software. Results: A total of twenty articles were included in the present analysis. In the overall analysis, no significant associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and the risk of radiotherapy adverse effects were found. We conducted subgroup analysis stratified by type of cancer, region and time of appearance of side effects subsequently. No significant association between ATM Asp1853Asn and risk of radiotherapy adverse effects was found in any subgroup analysis. For TP53 Arg72Pro, variant C allele was associated with decreased radiotherapy adverse effects risk among Asian cancer patients in the stratified analysis by region (OR=0.71, 95%CI: 0.54-0.93, p=0.012). No significant results were found in the subgroup analysis of tumor type and time of appearance of side effects. Conclusions: The TP53 Arg72Pro C allele might be a protective factor of radiotherapy-induced adverse effects among cancer patients from Asia. Further studies that take into consideration treatment-related factors and patient lifestyle including environmental exposures are warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Meta-analysis of Associations between ATM Asp1853Asn and TP53 Arg72Pro Polymorphisms and Adverse Effects of Cancer Radiotherapy

Su¹,

Yin²,

Wu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the relationship between irradiation parameters, complications, and tumor control is complex and still not precisely defined for most cancers and normal tissues (5)(6)(7). Electron irradiation has become readily available for use in radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…Previous experiments have demonstrated the inhibitory effect of x-radiation on newly formed connective tissue proliferation, which varied according to radiation delivery time in relation to the wound healing stage (5)(6)(7)(8)(9)13,14). This explains why the side effects of radiotherapy can be divided into acute and late side effects.…”

Section: Introductionmentioning

confidence: 99%

“…Both the late and acute irradiation side effects can be irreversible. Currently available knowledge about the pathogenesis of radiation-induced normal tissue injury has brought information for identifying tissue repair potential to prevent the side effects of irradiation (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…Despite the great number of previous investigations in radiobiology (4,5,7,8,10,(13)(14)(15)(16)(17), few studies have focused on the quantitative analysis of glycosaminoglycans (GAGs) in the granulation tissue of locally irradiated skin. Scientific evidences indicate that the influence of irradiation on connective tissue leads to the degradation of ground substance and produces severe disturbances in the metabolism of GAGs (10).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of low-dose electron radiation on rat skin wound healing

Almeida

Cruz

Ferreira³

et al. 2007

Braz. Dent. J.

View full text Add to dashboard Cite

The aim of this study was to assess the effect of low-dose electron irradiation on morphological features of the wound healing process in rat skin. Surgical wounds were inflicted with a 2.3 x 1.4 cm template on 84 male rats that were assigned to 4 groups: IG1, immediately irradiated; IG2, irradiated 3 days after inflicting the wound; CG1 and CG2, control groups. Rats in IG1 and IG2 groups had their wounds exposed to 1 Gy of 6 MeV electron beam radiation, immediately after surgery and on the third postoperative day, respectively. Qualitative and histophotometric evaluations of tissue repair structures were carried out. Data were analyzed by ANOVA and Tukey's test (α = 0.05) and regression analysis. The repair process was delayed since the first sacrifice time in both irradiated groups, but in IG1, wound healing was closer to that of CG1; whereas in IG2, the delay was more pronounced. Based on the histological findings, it is possible to conclude that a low-dose of electron radiation delayed tissue repair in rat skin. The delay was longer in the skin irradiated 3 days after the beginning of tissue repair. However, the low-energy electron irradiation did not prevent wound healing.

show abstract