Effects of radiation exposure on brain health: a state of the art and new challenges

Jayan, Jayalakshmi; Roshi, Harsha; Ashraf, Fathima Farzana Perumbilly; Nair, Parvathy G.; Vijayakumar, Aparna; Nair, Aathira Sujathan; Pappachen, Leena K.; Abdelgawad, Mohamed A.; Parambi, Della Grace Thomas; Aleya, Lotfi; Mathew, Bijo

doi:10.1007/s11356-022-23703-4

Cited by 2 publications

(3 citation statements)

References 72 publications

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“…1 CC is now widely used in the era of modern drug discovery, and its focus on neurodegenerative disorders (NDDs) is of interest. 31 1.2. Major Targets for the Treatment of Neurodegenerative Disorders.…”

Section: Introductionmentioning

confidence: 99%

“…Neurodegenerative disorders (NDDs) are characterized by particular protein accumulations known as amyloid beta (Aβ) plaques and cerebral amyloid angiopathy (CAA), tau-protein neurofibrillary tangles (NFTs), and neuropil threads (NTs) in the brains of the patients, causing neuronal dysfunction and leading to the progression of neurological impairment and mortality . The most common types of NDDs are Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis, and amyotrophic lateral sclerosis . Neuronal dysfunction occurs in many ways, including oxidative overload, free radical formation, collapse of mitochondrial function, compromised biological energy, neuronal malfunction, neuroinflammatory processes, and neuronal structural and functional errors .…”

Section: Introductionmentioning

confidence: 99%

“… 31 The most common types of NDDs are Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis, and amyotrophic lateral sclerosis. 32 Neuronal dysfunction occurs in many ways, including oxidative overload, free radical formation, collapse of mitochondrial function, compromised biological energy, neuronal malfunction, neuroinflammatory processes, and neuronal structural and functional errors. 33 Other mechanisms have been identified, such as mutations in leucine-rich repeat kinase 2 (LRRK2) and aggregation of α-synuclein in PD, and mutations in amyloid precursor protein (APP), PS1, and PS2 (presenilin 1 and 2) in AD.…”

Section: Introductionmentioning

confidence: 99%

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“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders

Manoharan,

Jayan,

Rangarajan

et al. 2023

ACS Omega

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Click chemistry is a set of easy, atom-economical reactions that are often utilized to combine two desired chemical entities. Click chemistry accelerates lead identification and optimization, reduces the complexity of chemical synthesis, and delivers extremely high yields without undesirable byproducts. The most well-known click chemistry reaction is the 1,3-dipolar cycloaddition of azides and alkynes to form 1,2,3triazoles. The resulting 1,2,3-triazoles can serve as both bioisosteres and linkers, leading to an increase in their use in the field of drug discovery. The current Review focuses on the use of click chemistry to identify new molecules for treating neurodegenerative diseases and in other areas such as peptide targeting and the quantification of biomolecules.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders

Manoharan,

Jayan,

Rangarajan

et al. 2023

ACS Omega

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Dual‐Confinement and Surface‐Ionization Induced Controllable Regulate Visible‐Light‐Activated Colorful Afterglow of Carbon Dots for Multifunctional Applications

Wang,

Ning,

Wen

et al. 2024

Small Methods

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Low‐energy visible‐light‐activated carbon dots (CDs)‐based afterglow materials are difficult to realize due to the inherent aromatic carbon with high‐energy absorption and the lack of effective regulation. Here, a new strategy for visible‐light‐activated CDs is proposed by combining dual‐confinement and surface‐ionization, which employs NaOH for additional confinement and surface ionization of CDs in a single boric acid (BA) matrix. The comparison experiments show that: i) shifting the excitation from UV‐light to vis‐light is realized by enhancing the low‐energy surface states n→π* transition of the CDs by surface ionization of NaOH. ii) CDs are additionally protected by a more stable Na─O ionic bond after NaOH confinement, resulting in a brighter afterglow. iii) the energy gap (ΔEST) between the lowest singlet and triplet states is gradually shortened as increasing NaOH content, facilitating intersystem crossing, prolonging the lifetime of triplet excitons and efficiency. Further, vis‐light‐excited colorful afterglow powders are fabricated based on Förster Resonant Energy Transfer by combining the fluorescent dye 5‐carboxytetramethylrhodamine. Finally, advanced white‐light‐activated time‐resolved anti‐counterfeiting and intelligent traffic flashing signs are realized. The work may shed new light on the design of low‐energy‐activated afterglow materials and broaden the application scenarios in the daily lives of human society.

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Effects of radiation exposure on brain health: a state of the art and new challenges

Cited by 2 publications

References 72 publications

“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders

“Click Chemistry”: An Emerging Tool for Developing a New Class of Structural Motifs against Various Neurodegenerative Disorders

Dual‐Confinement and Surface‐Ionization Induced Controllable Regulate Visible‐Light‐Activated Colorful Afterglow of Carbon Dots for Multifunctional Applications

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