Effects of Quercetin on the Severity of Chemically Induced Convulsions and 70-kDal Heat Shock Protein Content in Brain Structures in Rats

Nitsinskaya, L. E.; Екимова, И. В.; Guzhova, Irina V.; Feizulaev, B. A.; Pastukhov, Yu. F.

doi:10.1007/s11055-011-9472-z

Cited by 7 publications

(10 citation statements)

References 23 publications

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“…However, MDA-MB-231 cells did not show significant cytotoxicity to quercetin, though at 48h of 100μM quercetin treatment less than 40% of cells showed cytotoxicity ( Fig 1B ). We restricted our study, to lower concentrations of quercetin, as few other studies state that higher concentrations of quercetin become carcinogenic and induce risk of leukemia in young children [ 27 , 28 ]. Hence, we fixed up a minimal dosage of 40μM of quercetin for both the cell lines.…”

Section: Resultsmentioning

confidence: 99%

“…Although studies say that quercetin may protect against some forms of cancer when consumed in the diet [ 30 , 31 ]. However, there are also few studies which state that higher dosage of quercetin is carcinogenic and increases the risk of leukemia in young children [ 27 , 28 ]. Hence in this study, we restricted to lower dosage of quercetin.…”

Section: Discussionmentioning

confidence: 99%

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Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells

2015

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Quercetin is a dietary flavonoid which exerts anti-oxidant, anti-inflammatory and anti-cancer properties. In this study, we investigated the anti-proliferative effect of quercetin in two breast cancer cell lines (MCF-7 and MDA-MB-231), which differed in hormone receptor. IC50 value (37μM) of quercetin showed significant cytotoxicity in MCF-7 cells, which was not observed in MDA-MB-231 cells even at 100μM of quercetin treatment. To study the response of cancer cells to quercetin, with respect to different hormone receptors, both the cell lines were treated with a fixed concentration (40μM) of quercetin. MCF-7 cells on quercetin treatment showed more apoptotic cells with G1 phase arrest. In addition, quercetin effectively suppressed the expression of CyclinD1, p21, Twist and phospho p38MAPK, which was not observed in MDA-MB-231 cells. To analyse the molecular mechanism of quercetin in exerting an apoptotic effect in MCF-7 cells, Twist was over-expressed and the molecular changes were observed after quercetin administration. Quercetin effectively regulated the expression of Twist, in turn p16 and p21 which induced apoptosis in MCF-7 cells. In conclusion, quercetin induces apoptosis in breast cancer cells through suppression of Twist via p38MAPK pathway.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells

2015

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“…In fact, it was previously shown in several studies that rutin, quercetin and isoquercitrin have anticonvulsant effects on the experimental epilepsy models (Nassiri-Asl et al, 2008;Choudhary et al, 2011;Guo et al, 2011;Nitsinskaya et al, 2011). Additionally, Taviano et al (2007) reported that ursolic acid produced a protective effect against PTZ-induces seizures.…”

Section: Discussionmentioning

confidence: 97%

UPLC–TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities

Orhan

Aslan

et al. 2012

Journal of Ethnopharmacology

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“…The results obtained from studies on some animal models of epilepsy such as intravenous infusion pentylenetetrazol tests, maximal electroshock, and seizures induced by 6Hz stimulation showed that quercetin and rutin in some doses attenuate seizure factors only in the 6Hz induced seizure test and do not change seizure parameters in other models [ 49 ]. Proconvulsant effects have also been reported for quercetin on N-methyl D-aspartate (NMDA) and pentylenetetrazol induced seizures [ 50 ]. Therefore, it seems that free radical scavengers and antioxidants do not necessarily attenuate seizure symptoms.…”

Section: Discussionmentioning

confidence: 99%

Proconvulsant effects of Nepeta menthoides hydro alcoholic extract in different seizure tests: behavioral and biochemical studies

Rahmati

Fatemeh

Heydari

2020

Heliyon

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In Iran, both Nepeta menthoides-the endemic species of Nepeta genus-and Lavandula officinalis are known as Ustukhuddoos and used widely as medicinal herbs. In Iranian traditional medicine, Ustukhuddoos has been recommended for several neuronal diseases including depression and epilepsy. While the antiepileptic effects of Lavandula officinalis have been investigated in a number of studies, no reports are available taking into account the effect of Nepeta menthoides on epilepsy. Since convulsion is an important side effect of some medicinal plants, a thorough study of the effects of Nepeta menthoides on epilepsy seems necessary. This study was designed to investigate the potential anti-or pro-convulsant activity of Nepeta menthoides and its effects on oxidative stress markers. Since an herbal medicine showed opposite effects in two animal models of epilepsy in our laboratory, authers decided to study Nepeta effects through several seizure tests including the intravenous pentylenetetrazol (i.v. PTZ) infusion, the maximal electroshock (MES), acute PTZ and PTZ-kindling tests. These seizure models are generally used for screening pro-or anti-epileptic drugs. Nepeta menthoides (400 mg/kg) significantly reduced the dose of PTZ necessary for clonus seizure induction. Combining either phenytoin (Phen) or Valproate (Val) with Nepeta decreased their antiepileptic effects. Therefore, Nepeta menthoides not only failed to prevent the seizures but also increased sensitivity to them. Nepeta raised brain NO levels in different seizure tests. It seems there is a relation between NO elevation by Nepeta and increased sensitivity to seizures that should be investigated later.

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Effects of Quercetin on the Severity of Chemically Induced Convulsions and 70-kDal Heat Shock Protein Content in Brain Structures in Rats

Cited by 7 publications

References 23 publications

Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells

Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells

UPLC–TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities

Proconvulsant effects of Nepeta menthoides hydro alcoholic extract in different seizure tests: behavioral and biochemical studies

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