Effects of quercetin on microRNAs: A mechanistic review

Abstract

MicroRNA (miRNA)-dependent pathways are one of the newest gene regulation mechanisms in various diseases, particularly in cancers. miRNAs are endogenous noncoding RNAs with about 18 to 25 nucleotide length, which can regulate the expression of at least 60% of human total genome posttranscriptionally. Quercetin is the most abundant flavonoid in a variety of fruits, flowers, and medical herbs, known as a strong free radical scavenger that could show antioxidant, anti-inflammatory, and antitumor activities. Recent studies also reported its strong impact on various miRNA expressions in different abnormalities. In this review, we aimed to summarize the studies focused on the effects of quercetin on different miRNA expressions to more clear the main possible mechanisms of quercetin influences and introduce it as a beneficial agent for regulation of miRNAs in various biological directions.

Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway

“…Currently QS is marketed as a dietary supplement in several countries [15]. The protective effect of QS against cancer is due to its effect on miRNAs and their targets [16,17]. Sonoki et al showed that in lung adenocarcinoma cell lines, QS decreases claudin-2 expression through up-regulation of miRNA-16, which leads to reduction in proliferation and migration in lung cancer [18].…”

Exploring the Potential Mechanism of Guchang Zhixie Wan for Treating Ulcerative Colitis by Comprehensive Network Pharmacological Approaches and Molecular Docking Validation as Well as Cell Experiments

“…Quercetin, β‐sitosterol and kaempferol are common compounds found in many herbal medicines. Many scientific reports recognized that they possess antinociceptive, anxiolytic and sedative effects, analgesic, immunomodulatory, antimicrobial, anticancer, anti‐inflammatory, protective effects on respiratory diseases, wound‐healing effects, antioxidants, and so on [26–31] . Because of their numerous biological functions, they are considered as biologically active compounds and have been studied for the treatment of diseases through network pharmacology methods.…”

miRNAs and Novel Food Compounds Related to the Browning Process

“…This result may be mediated by the increased expression of Ucp-1 in sWAT [118]. Although the role of miRNAs as a potential mechanism involved in the regulation of the browning process has not been specially described, some miRNAs could be implicated in the inflammatory response [119]. In a recent study, the effect of quercetin on miR-155 expression in RAW264.7 macrophages stimulated with lipopolysaccharide (LPS) was evaluated.…”