Effects of puromycin on rat embryos in vitro

Flynn, Tom; Friedman, Leo; Black, T.N.

doi:10.1007/bf01940442

Cited by 1 publication

(3 citation statements)

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“…Photosensitive analogues of (19)have been used to label the A-site proteins of peptidyltransferase and tRNA Phe (50). Compound (19), and its carbocyclic analogue have been used to study the accumulation of glycoprotein-derived free sialooligosaccharides, accumulation of mRNA, methylase activity, enzyme transport, rat embryo development, the acceptor site of human placental 80S ribosomes, and gene expression in mammalian cells (51)(52)(53)(54)(55)(56)(57)(58)(59)(60). Three other 3 -aminoacyl-3 -deoxyadenosine nucleosides, homocitrullylaminoadenosine (20), lysylaminoadenosine (21), and chryscandin (22), have been reported (61).…”

Section: Puromycinmentioning

confidence: 99%

“…Tubercidin (51), toyocamycin (52), sangivamycin (53), cadeguomycin (54), and kanagawamicin (55) are pyrrolopyrimidine nucleoside antibiotics isolated from strains of Streptomyces (1-4, 151). In addition, the 5 -α-D-glucopyranosyl derivatives of tubercidin and toyocamycin have been isolated from blue-green algae (152).…”

Section: Pyrrolopyrimidine Nucleosidesmentioning

confidence: 99%

“…The molecular effects of (53) and its thio analogue on RNA and DNA synthesis in L1210 cells and as an inhibitor of rhodopsin kinase have been studied (167,168). Compound (54) potentiates the cytotoxicity of ara-C and has been used in studies on the T-cell immunostimulatory properties of certain peptides (169)(170)(171). Compound (55) has antitumor and antibacterial activity (172).…”

Section: Pyrrolopyrimidine Nucleosidesmentioning

confidence: 99%

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Nucleosides and Nucleotides

Suhadolnik¹,

Reichenbach²

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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The naturally occurring nucleoside and nucleotide antibiotics exist as either the C ‐ or N ‐glycosides. They include ezomycin A 1 (C 26 H 38 N 8 O 15 S), ezomycin B 1 (C 26 H 39 N 7 O 17 S), ezomycin C 1 (C 26 H 37 N 7 O 16 S), ezomycin A 2 (C 19 H 26 N 6 O 12 ), ezomycin B 2 (C 19 H 25 N 5 O 13 ), ezomycin C 2 (C 19 H 25 N 5 O 13 ), showdomycin (C 9 H 11 NO 6 ), isoshowdomycin (C 9 H 11 NO 6 ), maleimycin (C 7 H 7 NO 3 ), oxazinomycin (C 9 H 11 NO 7 ), pyrazomycin (pyrazofurin) (C 9 H 13 N 3 O 6 ), formycin (C 10 H 13 N 5 O 4 ), formycin B (C 10 H 12 N 4 O 5 ), oxoformycin B (C 10 H 12 N 4 O 6 ). These antibiotics contain a variety of purine and pyrimidine rings. The naturally occurring nucleoside/nucleotide antibiotics, which have been isolated from bacteria, fungi, blue‐green algae, and marine sponges, have proven to be useful biochemical probes in eucaryotic, procaryotic, viral, fungal, and plant systems. The purine nucleosides inhibit protein synthesis, RNA and DNA synthesis, and methyltransferases; they have antimycoplasmal, antiviral, hypotensive, antifungal, antimycobacterial, and antitumor activities and induce sporulation. The pyrimidine nucleosides inhibit protein synthesis, virus replication, RNA and DNA synthesis, and cAMP phosphodiesterase. The imidazole nucleosides inhibit nucleic acid synthesis. The diazepin nucleosides inhibit adenosine deaminase (ADA). The indole nucleosides inhibit bacteria, yeast, fungi, and viruses. The N ‐nucleotide antibiotics include agrocin 84 (C 21 H 34 N 6 O 16 P 2 ), thuringiensin (C 22 H 30 N 5 O 19 P), phosmidosine (C 16 H 24 N 7 O 8 P), fosfadecin (C 13 H 19 N 5 O 10 P 2 ), and fosfocytocin (C 12 H 20 N 4 O 13 P 2 ). Thuringiensin, produced by B. thuringiensis , is a β‐exotoxin that exerts its toxic action on insects and mammals through the inhibition of RNA polymerases. Phosmidosine inhibits pore formation of Botrytis cinerea and Aspergillus niger . Fosfadecin and fosfocytocin inhibit gram‐positive and gram‐negative bacteria.

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