Effects of Purinergic Stimulation on Ciliary Beat Frequency and Chloride Secretion in Sinusitis

Kim, In-Sang; Rhee, Chae‐Seo; Lee, Jun Ho; Heo, Jeong-Hwa; Park, Jerry; Lee, Chul Hee

doi:10.1097/mlg.0b013e31806911cc

Cited by 5 publications

(4 citation statements)

References 15 publications

(19 reference statements)

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“…ATP release from injured cells enhances the inflammatory response through increased synthesis of prostaglandin E 2 (PGE 2 ) [4] via P2X7 receptors [5]. P2X receptor involvement in inflammation also occurs in irritable bowel syndrome [6,7], lung injury and fibrosis [8,9], systemic inflammation [10], arthritis [11], fever [12], and rhinosinusitis [13]. Purinergic signalling in different inflammatory cells involves purinoceptor responses in immune cells (see [14]).…”

Section: Introductionmentioning

confidence: 99%

P2X ion channel receptors and inflammation

Burnstock

2016

Purinergic Signalling

182

153

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Neuroinflammation limits tissue damage in response to pathogens or injury and promotes repair. There are two stages of inflammation, initiation and resolution. P2X receptors are gaining attention in relation to immunology and inflammation. The P2X7 receptor in particular appears to be an essential immunomodulatory receptor, although P2X1 and P2X4 receptors also appear to be involved. ATP released from damaged or infected cells causes inflammation by release of inflammatory cytokines via P2X7 receptors and acts as a danger signal by occupying upregulated P2X receptors on immune cells to increase immune responses. The purinergic involvement in inflammation is being explored for the development of novel therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

P2X ion channel receptors and inflammation

Burnstock

2016

Purinergic Signalling

182

153

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“…These results imply that EMF‐induced homeostasis mechanisms for EMF exposure did not properly compensate. Previous studies showed that CBF in the mucosal explants from the majority of patients with chronic sinusitis was not different from that measured in the explants of healthy tissue 17. However, the increase of CBF by ATP showed differences between the two groups.…”

Section: Discussionmentioning

confidence: 71%

“…Previous studies showed that CBF in the mucosal explants from the majority of patients with chronic sinusitis was not different from that measured in the explants of healthy tissue. 17 However, the increase of CBF by ATP showed differences between the two groups. In the normal sinus mucosa group, 100 lM of ATP strongly stimulated CBF with an average increase of 30.1%, whereas the sinusitis group showed only a slight increase of CBF by ATP with a range of 3.2$12.2%.…”

Section: Discussionmentioning

confidence: 87%

The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa

Kim

Park

et al. 2012

The Laryngoscope

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“…Interestingly, two decades ago some studies had reported that exogenous addition of extracellular ATP can improve ciliary beat frequency (CBF) in epithelial cells derived from frog palate and esophagus [ 25 , 26 ]. The modulation of CBF was further shown to occur through activation of purinergic receptors present on the cilium [ 3 , 27 , 28 ]. Consistent with these findings, mutant mice lacking purinergic receptors showed a significant reduction in CBF [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway

et al. 2017

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Malignant transformation of cells is often accompanied by the loss of the primary cilium, a protruding microtubule-based sensory organelle, suggesting that it plays an “onco-suppressive” role. Therefore, restoration of the primary cilium is being explored as a new therapeutic approach to attenuate tumor growth. Recently, several commonly used chemotherapeutic drugs have been identified to induce the primary cilium in pancreatic cancer cells. The mechanisms by which these drugs re-express the cilium remain, however, enigmatic. Here, evaluation of a panel of diverse ciliogenic drugs on pancreatic cancer cell models revealed a significant positive relationship between drug-induced extracellular ATP, released through pannexin channels, and the extent of primary cilium induction. Moreover, cilium induction by these drugs was hampered in the presence of the ATP degrading enzyme, apyrase, and in the presence of the pan-purinergic receptor inhibitor, suramin. Our findings reveal that ciliogenic drug-induced re-expression of the primary cilium in pancreatic cancer cells is, at least in certain contexts, dependent on a hitherto unrecognized autocrine/paracrine loop involving the extracellular ATP-purinergic receptor signaling pathway that can be exploited in a therapeutic approach targeting at restoring the primary cilium.

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Effects of Purinergic Stimulation on Ciliary Beat Frequency and Chloride Secretion in Sinusitis

Cited by 5 publications

References 15 publications

P2X ion channel receptors and inflammation

P2X ion channel receptors and inflammation

The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa

Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway

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