Effects of pulsed infra-red low level-laser irradiation on open skin wound healing of healthy and streptozotocin-induced diabetic rats by biomechanical evaluation

Dadpay, Masoomeh; Sharifian, Zanelabedien; Bayat, Mohammad; Bayat, Mahdieh; Dabbagh, Ali

doi:10.1016/j.jphotobiol.2012.03.001

Cited by 60 publications

(39 citation statements)

References 56 publications

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“…Skin conditions improved in both groups that received LLLT. This finding is supported by recent studies that have demonstrated the effectiveness of LLLT when combined with combined fractional radiotherapy in the treatment of human acne (Yeung, Chan, Shek, & Chan, 2012) and open wounds in rat models (Dadpay, Sharifian, Bayat, Bayat, & Dabbagh, 2012; Hussein, Alfars, Falih, & Hassan, 2011). …”

Section: Discussionsupporting

confidence: 74%

A Pilot Randomized Trial Evaluating Low-Level Laser Therapy as an Alternative Treatment to Manual Lymphatic Drainage for Breast Cancer-Related Lymphedema

Ridner¹,

Poage-Hooper²,

Kanar³

et al. 2013

Oncology Nursing Forum

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Purpose/Objectives To examine the impact of advanced practice nurse (APN) administered low level laser therapy (LLLT) as both a stand-alone and complementary treatment for arm volume, symptoms, and quality of life (QOL) in women with breast cancer related lymphedema. Design A three-group, pilot, randomized clinical trial. Setting A private rehabilitation practice with two locations in the southwestern United States. Sample 46 breast cancer survivors with treatment related lymphedema. Methods Patients were screened for eligibility and then randomized to either manual lymphatic drainage (MLD) for 40 minutes, LLLT for 20 minutes, or, 20 minutes of MLD followed by 20 minutes of LLLT. Compression bandaging was applied after each treatment. Data were collected pre-treatment, daily, weekly, and at the end of treatment. Main Research Variables Independent variables consisted of three types of APN administered lymphedema treatment. Outcome variables included limb volume, extracellular fluid, psychological and physical symptoms, and QOL. Findings No statistically significant between group differences were found in volume reduction; however, all groups had clinically and statistically significant reduction in volume. No group differences were noted in psychological and physical symptoms, or QOL; however, treatment related improvements were noted in symptom burden within all groups. Skin improvement was noted in each group that received LLLT. Conclusions LLLT with bandaging may offer a time saving therapeutic option to conventional MLD. Alternatively compression bandaging alone could account for the demonstrated volume reduction. Implications for Nursing APNs can effectively treat lymphedema. APNs in private healthcare practices can serve as valuable research collaborators.

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Section: Discussionsupporting

confidence: 74%

A Pilot Randomized Trial Evaluating Low-Level Laser Therapy as an Alternative Treatment to Manual Lymphatic Drainage for Breast Cancer-Related Lymphedema

Ridner¹,

Poage-Hooper²,

Kanar³

et al. 2013

Oncology Nursing Forum

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“…LLLT at 0.03 J/cm 2 significantly decreased wound stiffness, whereas at 0.2 J/cm 2 , it significantly increased the maximum load in wounds from both the healthy control and diabetic groups. 32 Similarly, LLLT at 808 nm and 10 J/cm 2 improved incisional wound healing in diabetic rats; however, the tensile strength of wounds was not evaluated in this investigation. 33 Therefore, our study contributes to previously published investigations with novel information regarding wound stiffness in diabetic rats following LLLT at 810 nm.…”

Section: Discussionmentioning

confidence: 84%

“…31 In addition, it has also been shown that LLLT at 830 nm significantly enhanced skin wound TS in a mice diabetic model. 12 Laser irradiation at 890 nm displayed dose-dependent diverse effects on skin incisions.…”

Section: Discussionmentioning

confidence: 99%

Low-Level Laser Therapy with 810 nm Wavelength Improves Skin Wound Healing in Rats with Streptozotocin-Induced Diabetes

Dancakova

Vasilenko

Kováč

et al. 2014

Photomedicine and Laser Surgery

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Objective: The aim of present study was to evaluate whether low-level laser therapy (LLLT) can reverse the impaired wound healing process in diabetic rats. Background data: Impaired wound healing in diabetic patients represents a major health problem. Recent studies have indicated that LLLT may improve wound healing in diabetic rats, but the optimal treatment parameters are still unknown. Materials and methods: Male SpragueDawley rats (n = 21) were randomly divided into three groups: a healthy control group, a diabetic sham-treated group, and a diabetic LLLT-treated group. Diabetes mellitus was then induced by streptozotocin administration to the two diabetic groups. One 4 cm long full thickness skin incision and one full thickness circular excision (diameter = 4 mm) were performed on the back of each rat. An infrared 810 nm laser with an output of 30 mW, a power density of 30 mW/cm 2 , and a spot size of 1 cm 2 was used to irradiate each wound for 30 sec (daily dose of 0.9 J/cm 2 /wound/day). Results: In diabetic rats, the histology of LLLT-treated excisions revealed a similar healing response to that in nondiabetic controls, with significantly more mature granulation tissue than in the sham-treated diabetic control group. LLLT reduced the loss of tensile strength, and increased the incision wound stiffness significantly compared with sham-irradiated rats, but this did not achieve the same level as in the nondiabetic controls. Conclusions: Our study demonstrates that infrared LLLT can improve wound healing in diabetic rats. Nevertheless, further research needs to be performed to evaluate the exact underlying mechanism and to further optimize LLLT parameters for clinical use.

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“…Many previous studies have demonstrated that LLLT is optimal in tissues under a specific stress, such as hypoxia [32–34], diabetes [35–38], and nutritional deficit [39]. Other previous studies have shown that LLLT may enhance the osteogenic potential of osteoblasts, and may promote metabolic bone activity and bone remodeling [40, 41].…”

Section: Discussionmentioning

confidence: 99%

Effect of low-level laser therapy on bisphosphonate-treated osteoblasts

Shin

Kim

Choi

et al. 2016

Maxillofac Plast Reconstr Surg

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BackgroundThis study investigates the effect of alendronate-treated osteoblasts, as well as the effect of low-level laser therapy (LLLT) on the alendronate-treated osteoblasts. Bisphosphonate decreases the osteoblastic activity. Various treatment modalities are used to enhance the bisphosphonate-treated osteoblasts; however, there were no cell culture studies conducted using a low-level laser.MethodsHuman fetal osteoblastic (hFOB 1.19) cells were treated with 50 μM alendronate. Then, they were irradiated with a 1.2 J/cm2 low-level Ga-Al-As laser (λ = 808 ± 3 nm, 80 mW, and 80 mA; spot size, 1 cm2; NDLux, Seoul, Korea). The cell survivability was measured with the MTT assay. The three cytokines of osteoblasts, receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and macrophage colony-stimulating factor (M-CSF) were analyzed.ResultsIn the cells treated with alendronate at concentrations of 50 μM and higher, cell survivability significantly decreased after 48 h (p < 0.05). After the applications of low-level laser on alendronate-treated cells, cell survivability significantly increased at 72 h (p < 0.05). The expressions of OPG, RANKL, and M-CSF have decreased via the alendronate. The RANKL and M-CSF expressions have increased, but the OPG was not significantly affected by the LLLT.ConclusionsThe LLLT does not affect the OPG expression in the hFOB cell line, but it may increase the RANKL and M-CSF expressions, thereby resulting in positive effects on osteoclastogenesis and bone remodeling.

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Effects of pulsed infra-red low level-laser irradiation on open skin wound healing of healthy and streptozotocin-induced diabetic rats by biomechanical evaluation

Cited by 60 publications

References 56 publications

A Pilot Randomized Trial Evaluating Low-Level Laser Therapy as an Alternative Treatment to Manual Lymphatic Drainage for Breast Cancer-Related Lymphedema

A Pilot Randomized Trial Evaluating Low-Level Laser Therapy as an Alternative Treatment to Manual Lymphatic Drainage for Breast Cancer-Related Lymphedema

Low-Level Laser Therapy with 810 nm Wavelength Improves Skin Wound Healing in Rats with Streptozotocin-Induced Diabetes

Effect of low-level laser therapy on bisphosphonate-treated osteoblasts

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