Effects of pulse methylprednisolone and oral methylprednisolone treatments on serum levels of oxidative stress markers in Graves’ ophthalmopathy

Akarsu, Ersin; Büyükhatipoğlu, Hakan; Aktaran, Sebnem; Kurtul, Naciye

doi:10.1111/j.1365-2265.2010.03904.x

Cited by 41 publications

(42 citation statements)

References 32 publications

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“…Recently, Akarsu et al [43] further evaluated the relationship between GO and the effect of GC therapy (intravenous vs. oral) on serum of MDA and GSH. The study group included 33 recently diagnosed euthyroid GD patients with moderately severe and active GO, 20 euthyroid GD patients without GO, and 15 healthy controls.…”

Section: Oxidative Stress and Graves’ Orbitopathymentioning

confidence: 99%

Oxidative Stress in Graves Disease

Marcocci¹,

Leo²,

Altea³

2012

Eur Thyroid J

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Increased reactive oxygen species (ROS) generation and the consequent oxidative damage are involved in the development of several diseases, including autoimmune diseases. Graves’ disease is an autoimmune disorder characterized by hyperthyroidism and, less frequently, orbitopathy. Hyperthyroidism is characterized by increased oxidative stress. Untreated hyperthyroidism is associated with an increase of several parameters of oxidative stress and in most studies (but not all) by an increase of antioxidant defense enzymes. Restoration of euthyroidism with antithyroid drug is associated with a reversal of the biochemical abnormalities associated with oxidative stress. Animal and human studies suggest that increased ROS may directly contribute to some clinical manifestation of the disease, including orbitopathy. Antioxidants administered alone improve some clinical signs and symptoms of hyperthyroidism and, when associated with antithyroid drugs, induce a more rapid control of clinical manifestations and a faster achievement of euthyroidism. A large randomized clinical trial has shown that antioxidant supplementation (selenium) may also be beneficial for mild Graves’ orbitopathy.

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Section: Oxidative Stress and Graves’ Orbitopathymentioning

confidence: 99%

Oxidative Stress in Graves Disease

Marcocci¹,

Leo²,

Altea³

2012

Eur Thyroid J

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“…Therefore, thyroid hormone administration to vertebrates leads to an accelerated basal metabolic rate and oxygen consumption in the target tissues [1]. Both clinical [2,3] and experimental [1,4,5] studies have demonstrated that hyperthyroidism can cause an elevation in oxidative stress, most likely because of increased mitochondrial oxygen consumption. Mitochondria are the main production site of free oxygen radicals in healthy tissues because the leak of these radicals from the mitochondrial respiratory chain and the free oxygen radical production rate can be directly related to the rate of mitochondrial oxygen consumption [6].…”

Section: Introductionmentioning

confidence: 99%

“…The superoxide (O 2 .-), hydroxyl (HO), perhydroxyl radicals (HO 2 -) and nitric oxide (NO) are the most important free radicals that are derived from oxygen [7]. If not immediately neutralized, O 2 -radicals are converted to other reactive oxygen species (ROS), such as the HO radical and H 2 O 2 , by a classical Fenton reaction in the presence of iron. Because of their high reactivity and non-specific nature, ROS can attack almost all biomolecules present in their vicinity, including membrane lipids, causing oxidative stress in cells [4].…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Protective Effect of L-Carnitine on Oxidative Stress in the Livers of Hyperthyroid Rats

Yıldırım

Dane

et al. 2013

EAJM

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Objective: The present study was designed to investigate the dosedependent protective effect of L-carnitine (LC) on thyroid hormoneinduced oxidative stress in rat liver tissue. Materials and Methods:Twenty-one male Sprague Dawley rats were divided into four groups: control, hyperthyroidism, hyperthyroidism plus L-carnitine 100, and hyperthyroidism plus L-carnitine 500. Hyperthyroidism was induced in rats by injecting 250 μg of L-thyroxine/ kg body weight/day for twenty consecutive days. The activities of catalase (CAT), glutathione peroxidase (GPX) and myeloperoxidase (MPO) and the level of malondialdehyde (MDA) were measured in liver homogenates. Results:The liver CAT, GPX and MPO activities were significantly lower in the hyperthyroid rats than in the control group. Treating hyperthyroid rats with both low-dose (100 mg/kg) and high-dose (500 mg/kg) L-carnitine for 10 days resulted in a marked increase in the activities of the antioxidant enzymes in the liver tissue. Conclusion:The present study indicates that the low-dose L-carnitine application was sufficient to prevent L-thyroxine-induced oxidative stress in rat livers.Key Words: Catalase, glutathione peroxidase, L-carnitine, Liver, Malondialdehyde, Myeloperoxidase Özet Amaç: Bu çalışma rat karaciğer dokusunda tiroid hormonu ile uyarı-lan oksidatif stres üzerine L-karnitinin doza bağlı koruyucu etkilerini araştırmaktı. Gereç ve Yöntem:Yirmi bir erkek Sprague Dawley rat 4 gruba bö-lündü: Kontrol, hipertroidi, hipertiroidi + L-karnitine 100 ve hipertiroidi + L-karnitine 500. Hipertiroidi, yirmi gün boyunca ratlara 250 μg / kg dozunda L-Thyroxine enjeksiyonu uygulanarak oluşturuldu. Karaciğer homojenatlarında katalaz (CAT), glutatyon peroksidaz (GPX), myeloperoksidaz (MPO) aktiviteleri ve malondialdehit (MDA) düzeyleri ölçüldü. Bulgular:Kontrollerle karşılaştırıldığında hipertiroidili ratlarda karaciğer CAT, GPX ve MPO aktiviteleri belirgin olarak azaldı. 10 gün boyunca hem düşük doz (100 mg/kg) hem de yüksek doz (500 mg/ kg) L-karnitin uygulaması hipertiroidili ratlarda karaciğer antioksidan enzim aktivitelerinde belirgin bir artışa yol açtı.Sonuç: Bu çalışmanın sonuçları L-Tiroksin ile uyarılan rat karaciğerin-deki oksidatif stresi önlemek için düşük doz L-karnitin uygulamasının yeterli olduğunu göstermektedir.

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“…Systemic methylprednisolone administration has been shown to induce rat lens opacity (19) . The protective effect of methylprednisolone against oxidative injury has been found in several disease types (20)(21)(22)(23)(24) . However, no studies in the literature have related the impact of systemic methylprednisolone to the oxidative stress of crystalline lenses.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress of crystalline lens in rat menopausal model

Acer¹,

Pekel²,

Küçükatay³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate lenticular oxidative stress in rat menopausal models. Methods: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Group 1). From the rats that underwent oophorectomy, 10 formed the menopause control group (Group 2), 10 were administered a daily injection of methylprednisolone until the end of the study (Group 3), and the remaining 10 rats were administered intraperitoneal streptozocin to induce diabetes mellitus (Group 4). Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurements of the crystalline lenses were analyzed. Results: The mean OSI was the lowest in group 1 and highest in group 4. Nevertheless, the difference between the groups was not statistically significant in terms of OSI (p>0.05). The mean TOS values were similar between the groups (p>0.05), whereas the mean TAC of group 1 was significantly higher than that of the other groups (p<0.001). Conclusions:Our results indicate that menopause may not promote cataract formation.

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Effects of pulse methylprednisolone and oral methylprednisolone treatments on serum levels of oxidative stress markers in Graves’ ophthalmopathy

Abstract: Oxidative stress appears to be involved in the pathophysiology of GO. Relative to oral dosing, the intravenous administration of a glucocorticoid seems to yield more rapid improvement in disease activity. MDA might be useful as an indicator of clinical activity.

Cited by 41 publications

References 32 publications

Oxidative Stress in Graves Disease

Oxidative Stress in Graves Disease

Dose-Dependent Protective Effect of L-Carnitine on Oxidative Stress in the Livers of Hyperthyroid Rats

Oxidative stress of crystalline lens in rat menopausal model

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Effects of pulse methylprednisolone and oral methylprednisolone treatments on serum levels of oxidative stress markers in Graves’ ophthalmopathy

Abstract: Oxidative stress appears to be involved in the pathophysiology of GO. Relative to oral dosing, the intravenous administration of a glucocorticoid seems to yield more rapid improvement in disease activity. MDA might be useful as an indicator of clinical activity.

Cited by 41 publications

References 32 publications

Oxidative Stress in Graves Disease

Oxidative Stress in Graves Disease

Dose-Dependent Protective Effect of L-Carnitine on Oxidative Stress in the Livers of Hyperthyroid Rats

Oxidative stress of crystalline lens in rat menopausal model

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Oxidative Stress in Graves Disease

Oxidative Stress in Graves Disease