Effects of pulsatile blood flow in large vessels on thermal dose distribution during thermal therapy

Abstract

The aim of this study is to evaluate the effect of pulsatile blood flow in thermally significant blood vessels on the thermal lesion region during thermal therapy of tumor. A sinusoidally pulsatile velocity profile for blood flow was employed to simulate the cyclic effect of the heart beat on the blood flow. The evolution of temperature field was governed by the energy transport equation for blood flow together with Pennes' bioheat equation for perfused tissue encircling the blood vessel. The governing equations were numerically solved by a novel multi-block Chebyshev pseudospectral method and the accumulated thermal dose in tissue was computed. Numerical results show that pulsatile velocity profile, with various combinations of pulsatile amplitude and frequency, has little difference in effect on the thermal lesion region of tissue compared with uniform or parabolic velocity profile. However, some minor differences on the thermal lesion region of blood vessel is observed for middle-sized blood vessel. This consequence suggests that, in this kind of problem, we may as well do the simulation simply by a steady uniform velocity profile for blood flow.

Simulation and experimental studies on magnetic hyperthermia with use of superparamagnetic iron oxide nanoparticles

“…Bioheat transfer analysis often needs to deal simultaneously with transient and spatial heating inside living tissues. The Pennes bioheat transfer equation [26], which describes the exchange magnitude of the heat transfer between tissue and blood, has been used widely for solving the temperature distribution for thermal therapy [27,28]. We will perform a more detailed analysis by solving the Pennes bioheat transfer equation [26].…”

Effect of thermal radiation on MHD flow of blood and heat transfer in a permeable capillary in stretching motion

“…Shah et al [7] designed an instrument for measuring the heat convection coefficient on the endothelial surface of arteries. Effects of pulsatile blood flow in arteries during thermal therapy were studied by Craciunescu and Clegg [8] as well as by Horng et al [9]. Shrivastava and Roemer [10] studied heat transfer rate from one blood vessel to another and also that from a blood vessel to tissue.…”

A robust power deposition scheme for tumors with large counter-current blood vessels during hyperthermia treatment

“…We assumed an average uniform velocity profile for the blood fluid inside the vessels, as well as fully developed flow. Studies [20,21] have shown insignificant differences between uniform and non-uniform profiles (i.e. pulsating flow) inside the vessels.…”