Effects of puerarin on the retina and STAT3 expression in diabetic rats

Cai, Yonghao; Xiao-bi, Zhang; Xu, Xuegu; Yu, Yinfei

doi:10.3892/etm.2017.5203

Cited by 11 publications

(16 citation statements)

References 23 publications

(26 reference statements)

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“…Puerarin also decreased the blood glucose levels in STZ-induced diabetic rats. The present findings are consistent with previous studies showing that puerarin treatment exhibits hypoglycemic and retinal protective effects in diabetic rats (40,41).…”

Section: Discussionsupporting

confidence: 94%

Puerarin prevents cataract development and progression in diabetic rats through Nrf2/HO‑1 signaling

Zhang

2019

Mol Med Report

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Puerarin is the major bioactive ingredient isolated from the dry root of Pueraria lobata , a plant used in traditional Chinese medicine. Puerarin has been used to treat diabetes and cataracts in China; however, its underlying mechanism of action remains unclear. The aim of the present study was to investigate the effectiveness and mechanism of puerarin in preventing cataracts in diabetic rats. Diabetes was induced by streptozocin (STZ) administration and rats were intraperitoneally injected with puerarin (25, 50 and 100 mg/kg). Blood glucose levels and cataract development were examined in the different experimental groups. In addition, the expression levels of markers associated with oxidative stress, including nuclear factor erythroid 2 like 2 (Nrf2) and heme oxygenase-1 (HO-1), were analyzed. The present results suggested that treatment with puerarin at 25, 50 and 100 mg/kg significantly reduced blood glucose levels and the incidence of cataract in STZ-induced diabetic rats. Additionally, puerarin treatment reduced oxidative stress, restoring the levels of malondialdehyde and glutathione, and the activity of glutathione peroxidase. Furthermore, puerarin administration decreased the expression levels of retinal vascular endothelial growth factor and interleukin-1β and increased the mRNA expression levels of Nrf2 and HO-1, thus inhibiting oxidative stress. The present findings suggested that puerarin had hypoglycemic effects and that it prevented cataract development and progression in diabetic rats by reducing oxidative stress through the Nrf2/HO-1 signaling pathway.

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Section: Discussionsupporting

confidence: 94%

Puerarin prevents cataract development and progression in diabetic rats through Nrf2/HO‑1 signaling

Zhang

2019

Mol Med Report

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“…Puerarin exerts antiapoptotic and antioxidant effects in vitro and in vivo. STZ-induced T1DM rats treated with puerarin showed a reduction in morphological changes in the inner nuclear layer (INL) and outer nuclear layer (ONL), and augmented ONL thickness and b-wave amplitude [ 116 , 117 , 118 ]. The oxidative state was attenuated by a decrease in AGE accumulation and MDA content, and an increase in SOD activity [ 117 , 118 , 119 ].…”

Section: Diabetic Retinopathy and The Benefits Of Flavonoidsmentioning

confidence: 99%

“…STZ-induced T1DM rats treated with puerarin showed a reduction in morphological changes in the inner nuclear layer (INL) and outer nuclear layer (ONL), and augmented ONL thickness and b-wave amplitude [ 116 , 117 , 118 ]. The oxidative state was attenuated by a decrease in AGE accumulation and MDA content, and an increase in SOD activity [ 117 , 118 , 119 ]. Puerarin also downregulated VEGF, RAGE and HIF-1α expression and lowered STAT3 expression and protein levels in the retina [ 116 , 117 , 118 ].…”

Section: Diabetic Retinopathy and The Benefits Of Flavonoidsmentioning

confidence: 99%

“…The oxidative state was attenuated by a decrease in AGE accumulation and MDA content, and an increase in SOD activity [ 117 , 118 , 119 ]. Puerarin also downregulated VEGF, RAGE and HIF-1α expression and lowered STAT3 expression and protein levels in the retina [ 116 , 117 , 118 ]. Treated T1DM rats showed less retinal cell apoptosis and inhibited NF-κB p65 activity [ 120 ].…”

Section: Diabetic Retinopathy and The Benefits Of Flavonoidsmentioning

confidence: 99%

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The Benefits of Flavonoids in Diabetic Retinopathy

et al. 2020

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Diabetic retinopathy (DR), one of the most common complications of diabetes, is the leading cause of legal blindness among adults of working age in developed countries. After 20 years of diabetes, almost all patients suffering from type I diabetes mellitus and about 60% of type II diabetics have DR. Several studies have tried to identify drugs and therapies to treat DR though little attention has been given to flavonoids, one type of polyphenols, which can be found in high levels mainly in fruits and vegetables, but also in other foods such as grains, cocoa, green tea or even in red wine. Flavonoids have anti-inflammatory, antioxidant and antiviral effects. Since it is known that diabetes induces oxidative stress and inflammation in the retina leading to neuronal death in the early stages of the disease, the use of these compounds can prove to be beneficial in the prevention or treatment of DR. In this review, we summarize the molecular and cellular effects of flavonoids in the diabetic retina.

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“…Fushiming capsule (FSM), a compound traditional Chinese medicine, is composed of bioactivity components, such as puerarin, ginsenosides Rb1, ligustilide, aurantio obtusin, and chrysophanol [8]. Puerarin, being a vasodilator [9, 10], can reduce the oxidative stress damage of the retina [11, 12] and protect the retina through inhibiting inflammation and neuronal damage induced by proinflammatory factors [13, 14]. Ginsenosides Rb1 exhibits neuroprotective potential [15] and cytoprotective effects against oxidative stress-mediated apoptosis and other neuronal disturbances [16].…”

Section: Introductionmentioning

confidence: 99%

Fushiming Capsule Attenuates Diabetic Rat Retina Damage via Antioxidation and Anti-Inflammation

Long

Guo

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Aims. Diabetic retinopathy (DR) remains one of the leading causes of acquired blindness. Fushiming capsule (FSM), a compound traditional Chinese medicine, is clinically used for DR treatment in China. The present study was to investigate the effect of FSM on retinal alterations, inflammatory response, and oxidative stress triggered by diabetes. Main Methods. Diabetic rat model was induced by 6-week high-fat and high-sugar diet combined with 35 mg/kg streptozotocin (STZ). 30 days after successful establishment of diabetic rat model, full field electroretinography (ffERG) and optical coherence tomography (OCT) were performed to detect retinal pathological alterations. Then, FSM was administered to diabetic rats at different dosages for 42-day treatment and diabetic rats treated with Calcium dobesilate (CaD) capsule served as the positive group. Retinal function and structure were observed, and retinal vascular endothelial growth factor-α (VEGF-α), glial fibrillary acidic (GFAP), and vascular cell adhesion protein-1 (VCAM-1) expressions were measured both on mRNA and protein levels, and a series of blood metabolic indicators were also assessed. Key Findings. In DR rats, FSM (1.0 g/kg and 0.5 g/kg) treatment significantly restored retinal function (a higher amplitude of b-wave in dark-adaptation 3.0 and OPs2 wave) and prevented the decrease of retinal thickness including inner nuclear layer (INL), outer nuclear layer (ONL), and entire retina. Additionally, FSM dramatically decreased VEGF-α, GFAP, and VCAM-1 expressions in retinal tissues. Moreover, FSM notably improved serum antioxidative enzymes glutathione peroxidase, superoxide dismutase, and catalase activities, whereas it reduced serum advanced glycation end products, methane dicarboxylic aldehyde, nitric oxide, and total cholesterol and triglycerides levels. Significance. FSM could ameliorate diabetic rat retina damage possibly via inhibiting inflammation and improving antioxidation.

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Effects of puerarin on the retina and STAT3 expression in diabetic rats

Cited by 11 publications

References 23 publications

Puerarin prevents cataract development and progression in diabetic rats through Nrf2/HO‑1 signaling

Puerarin prevents cataract development and progression in diabetic rats through Nrf2/HO‑1 signaling

The Benefits of Flavonoids in Diabetic Retinopathy

Fushiming Capsule Attenuates Diabetic Rat Retina Damage via Antioxidation and Anti-Inflammation

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