Effects of pubertal exposure to thiazole-Zn on thyroid function and development in female rats

Yang, Huajun; Zhang, Wei; Kong, Qingxi; Liu, Huanliang; Sun, Rubao; Lin, Bencheng; Zhang, Hua‐Shan; Xi, Zhuge

doi:10.1016/j.fct.2012.11.003

Cited by 12 publications

(10 citation statements)

References 8 publications

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“…Stimulation by TSH results in thyroid follicular cell hypertrophy and hyperplasia, and the long-term stimulation of follicular cells by TSH in rats (especially males) increases the risk of developing thyroid follicular cell tumors in chronic toxicity studies (Hill et al, 1998;Saghir et al, 2008). In our previous study of a rodent 20-day Pubertal Female Assay, thiazole-Zn treatment clearly results in a thyroid hormone imbalance in rats, as evidenced by a statistically significant increase in the serum TSH and the presence of thyroid follicular cell hyperplasia in all of the thiazole-Zn-treated rats (Yang et al, 2013). Based on these data, the thyroid follicular cell neoplasms observed in this chronic study are considered to be secondary to thyroid hormone imbalance.…”

Section: Discussionmentioning

confidence: 95%

Thyroid follicular lesions induced by thiazole–Zn feed treatment for one year in Sprague-Dawley rats

Yang¹,

Kong²,

Liu³

et al. 2015

Experimental and Toxicologic Pathology

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Section: Discussionmentioning

confidence: 95%

Thyroid follicular lesions induced by thiazole–Zn feed treatment for one year in Sprague-Dawley rats

Yang¹,

Kong²,

Liu³

et al. 2015

Experimental and Toxicologic Pathology

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“…It is commonly known that the severity of hyperthyroidism is only partially correlated with serum FT4 and FT3 levels, and a report of 25 patients diagnosed with Graves' disease showed that there was no strong correlation between thyroid symptom spectrum and serum free thyroxine levels [ 15 ]. Studies have shown that, in patients who took thiazole zinc, serums TSH and TT4 changed significantly, while TT3 did not change significantly [ 16 ]. However, the asynchronous change of TT4 and TT3 is not well explained; therefore, it is generally agreed that TT3 does not reflect thyroid function very well.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Various Thyroid Hormones on Thyroid Function

Yuan

Liu

et al. 2014

International Journal of Endocrinology

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To clarify the clinical value of serums total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) and provide a more eligible and economic strategy to assess thyroid function. A total of 2,673 participants (500 patients with hyperthyroidism, 500 patients with hypothyroidism, and 1,673 healthy people) were involved in our study. Serums TT3, TT4, FT3, and FT4 and thyrotropin (TSH) were measured with VIDAS fluorescent enzyme immunoassay. The Pearson correlation between TT3, TT4, FT3, and FT4 and TSH was determined to identify the most important indicator for thyroid function besides TSH. The correlation of TT4, and FT4 with TSH was statistically significant in healthy individuals (P < 0.01), and the R-values were −0.065 and −0.152, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hyperthyroidism, and the R-values were −0.241, −0.225, −0.195, and −0.176, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hypothyroidism, and the R-values were −0.322, −0.262, −0.179, and −0.136, respectively. In our opinion, TSH and FT4 are the most valuable indicators in assessing thyroid function in a healthy population, and TSH and TT4 are the most meaningful in hyperthyroidism and hypothyroidism.

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“…The active ingredient of TDC microcapsules taken up by the plant causes severe damage to bacteria by thinning the skin of bacteria leading to their death. 49 The other is copper ion that strongly inhibit both fungal and bacterial growth. Aer exchanging with positive ions such as H + and K + ions on the cell surface of disease-producing germs, copper ions forms complex with the proteins of cell membrane leading to their death.…”

Section: Pot Experimentsmentioning

confidence: 99%

Synthesis of thiodiazole copper microcapsules and release behavior of inhibiting R. solanacearum

2014

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Microcapsules are one of the most useful devices to reduce the dosage of pesticides and prolong the duration of the active ingredient in target crops. In this study, thiadiazole copper (TDC) microcapsules were synthesized by in situ polymerization using poly(urea-formaldehyde) and characterized by field emission scanning electron microscopy, laser diffraction analysis, 3D optical microscopy, thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy. The effects of pH and temperature on the release of TDC were characterized by UV-visible absorption spectroscopy. The relationship between the micromechanical behavior of the microcapsules and release of TDC was studied by nanoindentation tests. The particle size distributions of the microcapsules (10-530 mm) were controlled by different reaction parameters. The microcapsules were stable below 220 C, as determined by TGA. The release kinetics indicated that the higher the temperature, the faster the release rate. The TDC microcapsules were sensitive to pH, and the fastest release rate was observed at pH 4.0. The maximum load, hardness, and Young's modulus under the same displacement conditions decreased during the release. Water swelling was the major reason for TDC release from the microcapsules. The pot experiments confirmed that the microcapsules exhibited long-term sustained release of TDC, thereby protecting the tobacco from R. solanacearum.

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Effects of pubertal exposure to thiazole-Zn on thyroid function and development in female rats

Cited by 12 publications

References 8 publications

Thyroid follicular lesions induced by thiazole–Zn feed treatment for one year in Sprague-Dawley rats

Thyroid follicular lesions induced by thiazole–Zn feed treatment for one year in Sprague-Dawley rats

Clinical Evaluation of Various Thyroid Hormones on Thyroid Function

Synthesis of thiodiazole copper microcapsules and release behavior of inhibiting R. solanacearum

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