Effects of psychosocial factors on monitoring treatment effect in newly diagnosed rheumatoid arthritis patients over time: response data from the tREACH study

Kuijper, M.; Luime, Jolanda J.; Xiong, Hui; Jong, Php de; Lubbe, P. van der; Zeben, Derkjen van; Tchetverikov, I.; Hazes, J. M. W.; Weel, A.

doi:10.1080/03009742.2017.1349176

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…RA is associated with several physical (eg, cardiovascular) and psychological comorbidities and it is increasingly recognised that depression and anxiety are associated with high disease activity, worse disease outcomes and decreased quality of life. [1][2][3][4][5][6] Most studies investigating the association of RA with depression and anxiety are cross-sectional and performed in patients with established RA of several years' duration 2 4 and/or in patients having received treatment for RA. 1 3 The frequency and relationship of psychological factors in early RA has been less studied and may differ from established RA.…”

Section: Introductionmentioning

confidence: 99%

Depression and anxiety in an early rheumatoid arthritis inception cohort. associations with demographic, socioeconomic and disease features

et al. 2020

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ObjectiveDepression and anxiety are not uncommon in Rheumatoid arthritis (RA). It is increasingly recognised that they are associated with high disease activity and worse disease outcomes. We aimed to examine the frequency of depression and anxiety in an early RA inception cohort and to explore associations with disease-related measures.MethodsThe Scottish Early Rheumatoid Arthritis inception cohort recruited newly diagnosed RA patients followed-up 6-monthly. Anxiety and depression were assessed using the hospital anxiety and depression scale. Associations with demographic characteristics and disease-related measures were examined at baseline, 6 months and 12 months.Results848 RA patients were included. The prevalence of anxiety and depression at baseline was 19.0% and 12.2%, respectively. Depression and anxiety scores correlated with DAS28 at all time-points (all p<0.0001). In multivariable linear regression, anxiety score at baseline was associated with younger age and Health Assessment Questionnaire (HAQ) score. Anxiety scores at 6 months and 12 months were associated with low body mass index (BMI), baseline anxiety score and current patient global score and HAQ. Depression score at baseline was associated with younger age, being single and HAQ, while depression scores at 6 months and 12 months were associated with male gender (only at 6 months), baseline anxiety and depression scores and current patient global score, HAQ and C-reactive protein (CRP) levels.ConclusionDepression and anxiety are associated with disease activity, worse functional status and other variables in early RA. There is a close relationship between CRP and depression but not anxiety.

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Section: Introductionmentioning

confidence: 99%

Depression and anxiety in an early rheumatoid arthritis inception cohort. associations with demographic, socioeconomic and disease features

et al. 2020

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“…However, the general trend indicates that the effect fades over time. One study with more frequent follow ups detailed this trend, with the effect only being significant at 13 weeks while the remaining follow ups for just over a year no longer showed an effect [ 25 ]. Another factor which influenced the results was the type of affective distress.…”

Section: Resultsmentioning

confidence: 99%

“…However, the differences were small (mostly 0.1 or fewer points difference) between the groups so the results also seem to point towards affective distress having less of an effect on SJC compared with other outcomes included in this review. In the three studies that distinguished between anxiety and depression, the direction of the effect was different in one, but it was very small and insignificant [ 25 ]. The remainder of studies that distinguished between anxiety and depression did not have any significant differences [ 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

Longitudinal effects of affective distress on disease outcomes in rheumatoid arthritis: a meta-analysis and systematic review

Sweeney,

Adas,

Cope

et al. 2024

Rheumatol Int

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Patients with rheumatoid arthritis have higher rates of mental health conditions compared to the general population. It is believed that affective distress and rheumatoid arthritis have a bi-directional relationship. This review will examine the associations between affective distress and rheumatoid arthritis outcomes over time. Several disease outcomes are included covering disease activity, function, and disability to provide a broad picture of the various ways patients are impacted. A quality assessment was also conducted. There were 71 studies included in the review. Three measures (disease activity, disability, and mortality) had enough data to complete meta-analyses of odds ratios or hazard ratios. The outcomes included were disease activity, tender joint count, swollen joints, pain, physician global assessment, patient global assessment, physical disability, acute phase reactants, stiffness, fatigue, work disability, and mortality. Numerous measures were included for most of the outcomes due to the variability across studies of measures used. Patients with affective distress had lower rates of remission according to the DAS-28, greater disability, and higher mortality. All of the outcomes covered had studies with mixed results, but swollen joint count, tender joint count, patient global assessment, and physician global assessment had the strongest evidence that they were associated with mental health longitudinally. The relationships between affective distress and disease outcomes are complex and vary depending on the measures. Overall, the effects fade over time. It is important for clinicians to be aware of the differing manifestations of the relationship between affective distress and rheumatoid arthritis outcomes.

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“…[8][9][10] As such, an association of anxiety, coping with pain and fatigue at baseline with disease activity after 3-12 months was reported. 11 Other analyses focused on illness perceptions in patients with RA and found a significant impact of illness perceptions on physical and mental HrQoL at baseline. 12 However, the association of initial illness perception on outcomes such as HrQoL and disease activity has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Treatment expectations as a possible prognostic factor for DMARD response in rheumatoid arthritis: a prospective cohort study

Mücke

Brinks

Dimitriou

et al. 2021

Therapeutic Advances in Musculoskeletal

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Background: The prediction of the individual’s response to disease modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA) is challenging and often limited. Here we evaluated the influence of patients’ expectations towards a change in treatment with DMARD on clinical outcome in RA. Methods: One hundred patients (74 female) with RA (2010 ACR/EULAR classification criteria) and an upcoming change in DMARD treatment due to non-response or adverse effects were included. Patients’ treatment beliefs, health-related quality of life and treatment expectations were measured using the Beliefs about Medicines Questionnaire (BMQ), the Short Form 36, and self-designed questions about expectations before treatment initiation (T0), and DAS28-CRP was calculated at T0 and after 4 months (T4). Associations between patients’ beliefs and expectations and changes in DAS28-CRP (T0 to T4, ΔDAS28-CRP) were explored by regression analyses after multiple imputation. Results: A total of 99 patients were included, of whom 84 completed all questionnaires. Thirty-six percent of all variability in treatment response (ΔDAS28-CRP) was explained by expectations assessed with the questionnaires and the C-reactive protein (CRP)-value at T0. Among these, the expected improvement rate, with 10.5%, as well as the CRP-value at T0, with 10.6%, had the greatest positive effect whereas the fear of adverse effects, with 11.4%, and the BMQ.concern scale, with 9.0%, had the greatest negative impact on ΔDAS28. Conclusion: Patients’ expectations towards newly induced DMARD therapies influence clinical response and may serve as possible explanatory factors for treatment response affecting subjective and objective outcome parameters. Clinical trial registration number: DRKS00017005

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Effects of psychosocial factors on monitoring treatment effect in newly diagnosed rheumatoid arthritis patients over time: response data from the tREACH study

Cited by 5 publications

References 18 publications

Depression and anxiety in an early rheumatoid arthritis inception cohort. associations with demographic, socioeconomic and disease features

Depression and anxiety in an early rheumatoid arthritis inception cohort. associations with demographic, socioeconomic and disease features

Longitudinal effects of affective distress on disease outcomes in rheumatoid arthritis: a meta-analysis and systematic review

Treatment expectations as a possible prognostic factor for DMARD response in rheumatoid arthritis: a prospective cohort study

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