Effects of psoralens as anti-tumoral agents in breast cancer cells

Panno, Maria Luisa; Giordano, Francesca

doi:10.5306/wjco.v5.i3.348

Cited by 43 publications

(29 citation statements)

References 94 publications

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“…Psoralen has been widely used as a traditional Chinese medicine due to its pharmacological activities, including its anti-tumor 17 , anti-inflammatory 18 , antipyretic and antibacterial activities. The transductional pathways activated by psoralen in target cells are still not well known today.…”

Section: Discussionmentioning

confidence: 99%

Psoralen induced cell cycle arrest by modulating Wnt/β-catenin pathway in breast cancer cells

Wang

Hua

et al. 2018

Sci Rep

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Psoralen could inhibit the proliferation of human breast cancer cells, however, the molecular mechanism was unclear. We evaluated the anti-proliferative effects of psoralen by MTT, plate colony formation assay and cell cycle analysis in MCF-7 and MDA-MB-231 cells. The effects of psoralen on activation of Wnt/β-catenin and the related target genes were examined by quantitative real-time PCR, western blotting and cell immunofluorescence. The tumor growth was conducted in BALB/c nude mice and the pathological changes of heart, liver and kidney were also observed. Our results demonstrate that psoralen significantly inhibited cell proliferation by inducing G0/G1 phase arrest in MCF-7 cells and G2/M phase arrest in MDA-MB-231 cells. The expression of Fra-1 was reduced and Axin2 was promoted both in MCF-7 and MDA-MB-231 cells after psoralen treatment. The cytoplasmic accumulation and nuclear translocation of β-catenin were significantly reduced by psoralen. Psoralen increased the levels of phospho-(Y142) β-catenin, while decreased the expression of total β-catenin and its downstream target Fra-1 in vitro and vivo. Moreover, psoralen didn’t cause any significant toxicity at the effective concentration. Overall, our results might provide theoretical basis for clinical application of psoralen in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Psoralen induced cell cycle arrest by modulating Wnt/β-catenin pathway in breast cancer cells

Wang

Hua

et al. 2018

Sci Rep

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“…Imperatorin significantly upregulates p53 and p21, which subsequently results in Mcl-1 down-regulation and Bax up-regulation in H23 human lung cancer cell [80] and HT 29 colon cancer cells [52] to inhibit their growth. Psoralen upregulates p21, waf and p53 in cells SKBR-3 MCF-7 cells, causing apoptosis [81,82]. Similarly, 5-geranyloxy-7-methoxy coumarin induces apoptosis in SW480 cells through the activation of tumor suppressor gene p53 [72].…”

Section: P53 Modulationmentioning

confidence: 99%

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Ahmed

Khan

Aschner

et al. 2020

IJMS

128

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Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents.

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“…On the other hand, their ability to interact with and disrupt DNA replication may represent a starting point to develop anti-cancer agents and therapies based on furanocoumarins [108]. Several in vitro studies have analyzed the inhibitory effects of furanocoumarins on the growth of various cancer cell lines, including breast cancer and non-small cell lung cancer [109,110,111], with psoralen representing a compound commonly employed for the treatment of cutaneous T cell lymphoma in extracorporeal photophoresis, where malignant cells are irradiated with UVA and then reinfused into the subject undergoing the treatment [112]. In recent studies, bergamottin, bergaptol, and bergapten have shown inhibitory effects on breast cancer cell growth.…”

Section: Biological Activities Of Furanocoumarinsmentioning

confidence: 99%

Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

et al. 2019

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The aim of this work is to provide a critical review of plant furanocoumarins from different points of view, including their chemistry and biosynthetic pathways to their extraction, analysis, and synthesis, to the main biological activities found for these active compounds, in order to highlight their potential within pharmaceutical science. The limits and the possible improvements needed for research involving these molecules are also highlighted and discussed.

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Effects of psoralens as anti-tumoral agents in breast cancer cells

Cited by 43 publications

References 94 publications

Psoralen induced cell cycle arrest by modulating Wnt/β-catenin pathway in breast cancer cells

Psoralen induced cell cycle arrest by modulating Wnt/β-catenin pathway in breast cancer cells

Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

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